Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jin-kyoung Shim"'
Autor:
Myeong Suk Yim, Yun Heung Kim, Hyeon Sang Bark, Seung Jae Oh, Inhee Maeng, Jin-Kyoung Shim, Jong Hee Chang, Seok-Gu Kang, Byeong Cheol Yoo, Jae Gwang Kwon, Jungsup Byun, Woon-Ha Yeo, Seung-Hwan Jung, Han-Cheol Ryu, Se Hoon Kim, Hyun Ju Choi, Young Bin Ji
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40452- (2024)
We used deep learning methods to develop an AI model capable of autonomously delineating cancerous regions in digital pathology images (H&E-stained images). By using a transgenic brain tumor model derived from the TS13-64 brain tumor cell line, we di
Externí odkaz:
https://doaj.org/article/e53685027e0a44b5b8df54c422c69b46
Autor:
Seo Jin Kim, Junseong Park, Jin-kyoung Shim, Ran Joo Choi, Ju Hyung Moon, Eui Hyun Kim, Wan-Yee Teo, Jong Hee Chang, Seok-Gu Kang
Publikováno v:
Translational Oncology, Vol 51, Iss , Pp 102197- (2025)
Background: Despite available treatment approaches, including surgical resection along with chemotherapy and radiotherapy, glioblastoma (GBM), the most prevalent primary brain tumor, remains associated with a grim prognosis. Although radiotherapy is
Externí odkaz:
https://doaj.org/article/cfb99612e8b540828a5371a1405ed06d
Autor:
Junseong Park, Ilkyoo Koh, Junghwa Cha, Yoojung Oh, Jin-Kyoung Shim, Hyejin Kim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Pilnam Kim, Seok-Gu Kang
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 529 (2024)
No standardized in vitro cell culture models for glioblastoma (GBM) have yet been established, excluding the traditional two-dimensional culture. GBM tumorspheres (TSs) have been highlighted as a good model platform for testing drug effects and chara
Externí odkaz:
https://doaj.org/article/f94660299f424372846807a19a4e75c9
Autor:
Jin-Kyoung Shim, Seonah Choi, Seon-Jin Yoon, Ran Joo Choi, Junseong Park, Eun Hee Lee, Hye Joung Cho, Suji Lee, Wan-Yee Teo, Ju Hyung Moon, Hyun Sil Kim, Eui Hyun Kim, Jae-Ho Cheong, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma (GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor exerts cytotoxic effects in GBM, which involve interr
Externí odkaz:
https://doaj.org/article/81126cca355a41108090049fa85eea74
Autor:
Jin-Kyoung Shim, Seung Hoon Lim, Ji Hye Jeong, Ran Joo Choi, Yoojung Oh, Junseong Park, Sunghee Choi, Junpyo Hong, Seo Jin Kim, Ju Hyung Moon, Eui Hyun Kim, Wan-Yee Teo, Bong Jin Park, Jong Hee Chang, Jae-Ha Ryu, Seok-Gu Kang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Forkhead Box M1 (FOXM1) is known to regulate cell proliferation, apoptosis and tumorigenesis. The lignan, (−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol (DFS), from Alnus japonica has shown anti-cancer effects against colon cancer cells
Externí odkaz:
https://doaj.org/article/252a5f0689a94714b6f6b4d7ca9e3c69
Autor:
Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh, Seok-Gu Kang
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells. Here, we have exa
Externí odkaz:
https://doaj.org/article/e26bd9e55f2b41eca5ae0c1087505d7e
Autor:
Ki‐Chun Yoo, Jae‐Hyeok Kang, Mi‐Young Choi, Yongjoon Suh, Yi Zhao, Min‐Jung Kim, Jong Hee Chang, Jin‐Kyoung Shim, Seon‐Jin Yoon, Seok‐Gu Kang, Su‐Jae Lee
Publikováno v:
Advanced Science, Vol 9, Iss 2, Pp n/a-n/a (2022)
Abstract Despite aggressive clinical treatment, recurrence of glioblastoma multiforme (GBM) is unavoidable, and the clinical outcome is still poor. A convincing explanation is the phenotypic transition of GBM cells upon aggressive treatment such as r
Externí odkaz:
https://doaj.org/article/eb08756678be4f74a0d7d5071c9c65e2
Autor:
Boram Lee, Eunsoo Lee, June Hoan Kim, Hyung-Jin Kim, Yong Guk Kang, Hyun Jung Kim, Jin-Kyoung Shim, Seok-Gu Kang, Beop-Min Kim, Karam Kim, Youseok Kim, Keunchang Cho, Woong Sun
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102267- (2021)
Summary: Optical clearing has emerged as a powerful tool for volume imaging. Although volume imaging with immunostaining have been successful in many protocols, yet obtaining homogeneously stained thick samples remains challenging. Here, we propose a
Externí odkaz:
https://doaj.org/article/35bc07c18b134122879a60efecd9f318
Autor:
Hee Yeon Kim, Dong Keon Kim, Seung-Hyun Bae, HyeRan Gwak, Ji Hoon Jeon, Jong Kwang Kim, Byung Il Lee, Hye Jin You, Dong Hoon Shin, Young-Ho Kim, Soo Youl Kim, Sung-Sik Han, Jin-Kyoung Shim, Ji-Hyun Lee, Seok-Gu Kang, Hyonchol Jang
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 10, Pp 1-12 (2018)
Brain cancer: Enzyme target for potential therapy A drug that targets a key enzyme in aggressive brain cancer tumors could help tackle resistance to existing treatments. Glioblastoma is the most aggressive form of brain cancer and remains difficult t
Externí odkaz:
https://doaj.org/article/f5bde652b6794bac89129022c500c7fa
Autor:
Junseong Park, Chang Gon Kim, Jin-Kyoung Shim, Jong Hoon Kim, Hoyoung Lee, Jae Eun Lee, Min Hwan Kim, Keeok Haam, Inkyung Jung, Su-Hyung Park, Jong Hee Chang, Eui-Cheol Shin, Seok-Gu Kang
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Background: Although programmed death-1 (PD-1) blockade is effective in treating several types of cancer, the efficacy of this agent in glioblastoma (GBM) is largely unknown. Methods: We evaluated therapeutic effects of anti-PD-1, temozolomide (TMZ),
Externí odkaz:
https://doaj.org/article/49035e22dd0941cbbe46fe50ff990e03