Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jin-Ying Tian"'
Autor:
Chun-Ping Liu, Xiong Li, Ge-Na Lai, Jin-Hua Li, Wen-Yu Jia, Ying-Ying Cao, Wen-Xing Xu, Qing-Long Tan, Chang-Yuan Zhou, Min Luo, Xue-Ying Zhang, Dao-Qing Yuan, Jin-Ying Tian, Xian Zhang, Xing Zeng
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Bladder cancer is one of the most malignant tumors closely associated with macrophage immune dysfunction. The Chinese medicine polyporus has shown excellent efficacy in treating bladder cancer, with minimal side effects. However, its material basis a
Externí odkaz:
https://doaj.org/article/e05c61cdda614ab2af193bb77829fd69
EGb761, an extract of Ginkgo biloba leaves, reduces insulin resistance in a high-fat-fed mouse model
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 1, Iss 1, Pp 14-20 (2011)
EGb761, a standardized and well-defined product extract of Ginkgo biloba leaves, has beneficial effects on the treatment of multiple diseases, including diabetes and dyslipidemia. However, it is still unclear whether EGb761 can increase insulin sensi
Externí odkaz:
https://doaj.org/article/1b84ef437aa04ab59960a2bd1b57b82a
Publikováno v:
Journal of Chemical Information and Modeling. 61:4720-4732
Protein tyrosine phosphatase 1B (PTP1B) is an intractable target for drug discovery due to its conservative and cationic catalytic site. Targeting alternative allosteric sites of PTP1B is a promising strategy to achieve specificity and bioavailabilit
Autor:
Jian-Bo Yang, Cheng-Shuo Yang, Jiang Li, Guo-Zhu Su, Jin-Ying Tian, Ying Wang, Yue Liu, Feng Wei, Yong Li, Fei Ye, Shuang-Cheng Ma
Publikováno v:
Bioorganic Chemistry. 135:106491
Autor:
Xing-Yan Sun, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Jin-ying Tian, Li Li, Yu-Huan Li, Fei Ye, Dong-Ming Zhang
Publikováno v:
Bioorganic Chemistry. 134:106458
Unusual N-pyridinium amino acid-type alkaloids from roots and rhizomes of Sophora tonkinensis Gagnep
Autor:
Xin Li, Ning Zhang, Sheng-Li Yang, Hao-Ke He, Qian-Ru Zhang, Yu Chen, Xiao-Jiao Zhou, Jin-Ying Tian, Fei Ye, Su-Juan Wang
Publikováno v:
Fitoterapia. 165:105388
Two previously undescribed amino acid-type alkaloids with unusual N-pyridinium cation (1-2) and six known alkaloids (3-8), were isolated from the roots and rhizomes of Sophora tonkinensis Gapnea. Their structures were characterized by UV, IR, NMR, an
Publikováno v:
RSC Advances. 10:27752-27763
As a critical enzyme for the uric acid production, xanthine oxidase (XO) has emerged as a primary drug target for antihyperuricemic therapy. A hierarchical virtual screening integrating both ligand-based and structure-based approaches was applied her
Autor:
Guang-Zhen Lang, Jie Ma, Jing-Zhi Yang, Dong-Ming Zhang, Jin-Ying Tian, Chuang-Jun Li, Yingda Zang, Hu-Tong-Yue Gao, Fei Ye, Pan-Pan Gao
Publikováno v:
Bioorganic chemistry. 112
Nine undescribed monoterpene phenol dimers, bisbakuchiols D-L (1–9), were isolated from the fruits of Psoralea corylifolia L. Their structures were elucidated based on extensive spectral analysis. The absolute configurations of 1–9 were specified
Autor:
Zheng Chen, Yanbo Tang, Xiaolin Zhang, Zhiyan Xiao, Fei Ye, Wenwen Yin, Jin-Ying Tian, Guanglei Nan
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 8, Iss 6, Pp 919-932 (2018)
Acta Pharmaceutica Sinica B, Vol 8, Iss 6, Pp 919-932 (2018)
Based on a non-competitive and selective PTP1B inhibitor reported by us previously, thirty-nine benzamido derivatives were designed and synthesized as novel PTP1B inhibitors. Among them, twelve compounds exhibited IC50 values at micromolar level agai
Publikováno v:
Bioorganic chemistry. 98
Protein tyrosine phosphatase 1B (PTP1B) is emerging as a promising yet challenging target for drug discovery. To identify natural products as new prototypes for PTP1B inhibitors, we employed a hierarchical protocol combining ligand-based and structur