Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jin-Xue He"'
Autor:
Li‐Min Wang, Pingyuan Wang, Xiao‐Min Chen, Hui Yang, Shan‐Shan Song, Zilan Song, Li Jia, Hua‐Dong Chen, Xu‐Bin Bao, Ne Guo, Xia‐Juan Huan, Yong Xi, Yan‐Yan Shen, Xin‐Ying Yang, Yi Su, Yi‐Ming Sun, Ying‐Lei Gao, Yi Chen, Jian Ding, Jing‐Yu Lang, Ze‐Hong Miao, Ao Zhang, Jin‐Xue He
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients fail to respond to PARPi. Here, we report that thioparib, a next‐generat
Externí odkaz:
https://doaj.org/article/24325773452c46108ba801e5debd9f21
Autor:
Li-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, Shan-Shan Song, Xu-Bin Bao, Xia-Juan Huan, Tong-Yan Wang, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100823- (2022)
Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attractive anticancer strategy with the discovery of the first-in-class NAE inhibitor, MLN4924. In this study, we identified SOMCL-1
Externí odkaz:
https://doaj.org/article/b631d181d8ac4e6eaba5e0c1b074aaac
Autor:
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Abstract Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high rate of resistan
Externí odkaz:
https://doaj.org/article/aa58f0bfd0a740678bf052d1f92375c9
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
PDF file - 796K, SK-OV-3, HCC1937, 786-O, MDA-MB-436, and HCC1937 cells exposed to triptolide, then harvested by Western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b13d961e3903dd883ab4c31a00308a3
https://doi.org/10.1158/0008-5472.22394003
https://doi.org/10.1158/0008-5472.22394003
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
PDF file - 1.1MB, Cells were treated with gradient concentrations of triptolide, then harvested by Western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0506f0e18d97c5105b6f52a354b644ea
https://doi.org/10.1158/0008-5472.22394006
https://doi.org/10.1158/0008-5472.22394006
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
Triptolide is a bioactive ingredient in traditional Chinese medicine that exhibits diverse biologic properties, including anticancer properties. Among its many putative targets, this compound has been reported to bind to XPB, the largest subunit of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a27a9bb3122eddbf0b4131043c0301
https://doi.org/10.1158/0008-5472.c.6503924.v1
https://doi.org/10.1158/0008-5472.c.6503924.v1
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
PDF file - 63K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf1fbbf48d81f537782deca395d8168
https://doi.org/10.1158/0008-5472.22394000
https://doi.org/10.1158/0008-5472.22394000
Autor:
Li‐Min Wang, Pingyuan Wang, Xiao‐Min Chen, Hui Yang, Shan‐Shan Song, Zilan Song, Li Jia, Hua‐Dong Chen, Xu‐Bin Bao, Ne Guo, Xia‐Juan Huan, Yong Xi, Yan‐Yan Shen, Xin‐Ying Yang, Yi Su, Yi‐Ming Sun, Ying‐Lei Gao, Yi Chen, Jian Ding, Jing‐Yu Lang, Ze‐Hong Miao, Ao Zhang, Jin‐Xue He
Publikováno v:
EMBO Molecular Medicine. 15
Publikováno v:
Cancer Biology & Therapy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
PARP1 and Chk1 inhibitors have been shown to be synergistic in different cancer models in relatively short time treatment modes. However, the consequences of long-term/repeated treatments with the combinations in cancer models remain unclear. In this
Autor:
Huaqian Ding, Jing Tan, Xu-Bin Bao, Shanshan Song, Jiannan Zhao, Ning Zhang, Jin-Xue He, Chaodong Xiong, Ze-Hong Miao, Ao Zhang, Li-Na Zhou
Publikováno v:
Journal of Medicinal Chemistry. 64:6161-6178
The ubiquitin-like protein NEDD8 is a critical signaling molecule implicated in the functional maintenance and homeostasis of cells. Dysregulation of this process is involved in a variety of human diseases, including cancer. Therefore, NEDD8-activati