Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Jin-Xiu Pan"'
Autor:
Lei Xiong, Hao-Han Guo, Jin-Xiu Pan, Xiao Ren, Daehoon Lee, Li Chen, Lin Mei, Wen-Cheng Xiong
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) differentiation and function. Exactly how Wnt/β-catenin signaling is regulated in OBs remain elusive. ATP6AP2, an accessor
Externí odkaz:
https://doaj.org/article/4b60a29c0bfb4751be8d9f9ad8514977
Autor:
Jin-Xiu Pan, Daehoon Lee, Dong Sun, Kai Zhao, Lei Xiong, Hao-Han Guo, Xiao Ren, Peng Chen, Raquel Lopez de Boer, Yuyi Lu, Helena Lin, Lin Mei, Wen-Cheng Xiong
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-11 (2022)
Abstract Alzheimer’s disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct link and relationship remain poorly understood. Here, we generated a mouse line, TgAPP swe H
Externí odkaz:
https://doaj.org/article/5c49075f0c724e7dbad4a75085b44098
Autor:
Jin-Xiu Pan, Dong Sun, Daehoon Lee, Lei Xiong, Xiao Ren, Hao-han Guo, Ling-Ling Yao, Yuyi Lu, Caroline Jung, Wen-Cheng Xiong
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes.
Externí odkaz:
https://doaj.org/article/6d1fdf67c02a4431b8721cdb4dab2785
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patients, and what are the relationsh
Externí odkaz:
https://doaj.org/article/fb9cc548fd604b8d828b13e62d3f18f9
Autor:
Hao-Han Guo, Lei Xiong, Jin-Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei, Wen-Cheng Xiong
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Patients with Alzheimer’s disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive. Previously, we found that Tg2576 mice, an AD animal model that ubiquitously expresse
Externí odkaz:
https://doaj.org/article/9f92161a88324128a0facf46d4549b1d
Autor:
Xiao Ren, Ling-Ling Yao, Jin-Xiu Pan, Jun-Shi Zhang, Lin Mei, Yong-Gang Wang, Wen-Cheng Xiong
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105339- (2021)
Moyamoya-like vasculopathy, the “puff of smoke”-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a rare cerebrovascular disease, and later found in patients with various types of neurological condi
Externí odkaz:
https://doaj.org/article/f8e42d1dc71645628ba9c3e3d800f97c
Autor:
Lei Xiong, Kai Zhao, Yu Cao, Hao-Han Guo, Jin-Xiu Pan, Xiao Yang, Xiao Ren, Lin Mei, Wen-Cheng Xiong
Publikováno v:
PLoS Biology, Vol 18, Iss 6, p e3000731 (2020)
The nuclear lamina protein lamin A/C is a key component of the nuclear envelope. Mutations in the lamin A/C gene (LMNA) are identified in patients with various types of laminopathy-containing diseases, which have features of accelerated aging and ost
Externí odkaz:
https://doaj.org/article/3dbb495dd91348ecb549d592c3163ade
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 45-60 (2016)
Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic response). Although its signaling and function have been extensively investigated, it just began
Externí odkaz:
https://doaj.org/article/d08d47bcc3f34dad85e86f3c2bc0da1b
Autor:
Shun Cui, Wen Cheng Xiong, Xiao Yang, Xiao Ren, Hao-Han Guo, Bo Wang, Lin Mei, Lei Xiong, Daehoon Lee, Jin-Xiu Pan, Kevin Liu
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-15 (2021)
Bone Research
Bone Research
Patients with Alzheimer’s disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive. Previously, we found that Tg2576 mice, an AD animal model that ubiquitously expresses Swedish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e064a495cfbb51e01e94470eaf8bd38
https://doaj.org/article/9f92161a88324128a0facf46d4549b1d
https://doaj.org/article/9f92161a88324128a0facf46d4549b1d
Autor:
Xiao Ren, Chen Shen, Ling Ling Yao, Jin-Xiu Pan, Wen Bing Chen, Dong Sun, Leena Milibari, Wen Cheng Xiong, Yang Zhao, Fu Lei Tang, Jun Shi Zhang, Lin Mei, Daehoon Lee
Publikováno v:
Biological Psychiatry. 89:600-614
Background Dentate gyrus (DG), a “gate” that controls information flow into the hippocampus, plays important roles in regulating both cognitive (e.g., spatial learning and memory) and mood behaviors. Deficits in DG neurons contribute to the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476a355421ba5fdcb1323f491143fbb4
https://doi.org/10.1016/j.biopsych.2020.08.026
https://doi.org/10.1016/j.biopsych.2020.08.026