Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Jin-Tang Dong"'
Autor:
Qingqing Huang, Mingcheng Liu, Duo Zhang, Bing-Biao Lin, Xing Fu, Zhiqian Zhang, Baotong Zhang, Jin-Tang Dong
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available therapies, leading to the death of patients. Enriched in the bone, TGF-β plays a pivotal role
Externí odkaz:
https://doaj.org/article/58f850f084a047aa8eaa6ba8c79a54cf
Autor:
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and r
Externí odkaz:
https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af44
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Hepatocellular carcinoma (HCC) is a common malignancy with higher mortality, and means are urgently needed to improve the prognosis. T cell exclusion (TCE) plays a pivotal role in immune evasion, and lncRNAs represent a large group of tumor developme
Externí odkaz:
https://doaj.org/article/a635cc66d1b44657b730eda9b528966b
Autor:
Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following and
Externí odkaz:
https://doaj.org/article/f0e28e9d788c4ece9cb9e8d8bdcafded
Publikováno v:
FEBS Open Bio, Vol 8, Iss 12, Pp 1943-1952 (2018)
The novel zinc finger protein 121 (ZNF121) has been demonstrated to physically and functionally associate with the MYC oncoprotein to regulate cell proliferation and likely breast cancer development. To further understand how ZNF121 functions in cell
Externí odkaz:
https://doaj.org/article/3dbdc0b23ae1485198e8e5384f4be506
Autor:
Ang Gao, Tonghua Sun, Gui Ma, Jiangran Cao, Qingxia Hu, Ling Chen, Yanxin Wang, Qianying Wang, Jiafu Sun, Rui Wu, Qiao Wu, Jiaxi Zhou, Lin Liu, Junjie Hu, Jin-Tang Dong, Zhengmao Zhu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Tamoxifen resistance is a major problem in the treatment of ERa positive breast cancer. Here, the authors show that LEM4 confers tamoxifen resistance by activating the cyclin D-CDK4/6-Rb axis and ERa signaling in endocrine-resistant breast cancer.
Externí odkaz:
https://doaj.org/article/7ff9424b6d604decaed08aa4fac77058
Autor:
Xiaodong Sun, Xiaoying Fu, Jie Li, Changsheng Xing, Henry F. Frierson, Hao Wu, Xiaokun Ding, Tongzhong Ju, Richard D. Cummings, Jin-Tang Dong
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 5, Pp 377-389 (2014)
The ATBF1/ZFHX3 gene at 16q22 is the second most frequently mutated gene in human prostate cancer and has reduced expression or mislocalization in several types of human tumors. Nonetheless, the hypothesis that ATBF1 has a tumor suppressor function i
Externí odkaz:
https://doaj.org/article/34b1fd57339d4c61bf61c3205b0843ef
Autor:
Dan Zhao, Jin-Tang Dong
Publikováno v:
Non-Coding RNA, Vol 4, Iss 4, p 39 (2018)
DRAIC (also known as LOC145837 and RP11-279F6.1), is a long non-coding RNA associated with several types of cancer including prostate cancer, lung cancer, and breast cancer. Its expression is elevated in tumor tissues compared to adjacent benign tiss
Externí odkaz:
https://doaj.org/article/69549bf76b5042a6acc1fc1e97aae327
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92746 (2014)
ATBF1/ZFHX3 is a large transcription factor that functions in development, tumorigenesis and other biological processes. ATBF1 is normally localized in the nucleus, but is often mislocalized in the cytoplasm in cancer cells. The mechanism underlying
Externí odkaz:
https://doaj.org/article/f6b67634a80c45f68a3a0efd89fb8a81
Autor:
Abel Martin-Garrido, Holly C Williams, Minyoung Lee, Bonnie Seidel-Rogol, Xinpei Ci, Jin-Tang Dong, Bernard Lassègue, Alejandra San Martín, Kathy K Griendling
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79657 (2013)
In adult tissue, vascular smooth muscle cells (VSMCs) exist in a differentiated phenotype, which is defined by the expression of contractile proteins and lack of proliferation. After vascular injury, VSMC adopt a synthetic phenotype associated with p
Externí odkaz:
https://doaj.org/article/fe7e3d05cfa5443490afb86850d03f2b