Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jin-Qiang Hou"'
Autor:
Wei Long, Bo-Xin Zheng, Ying Li, Xuan-He Huang, Dan-Min Lin, Cui-Cui Chen, Jin-Qiang Hou, Tian-Miao Ou, Wing-Leung Wong, Kun Zhang, Yu-Jing Lu
Publikováno v:
Nucleic Acids Research. 50:1829-1848
DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd6775f06f0cb51c1153088a65bf06d
https://doi.org/10.1093/nar/gkac090
https://doi.org/10.1093/nar/gkac090
Akademický článek
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Autor:
Qi Guo, Dongli Li, Yu Jing Lu, Jin-Qiang Hou, Deng Qiang, Wei Long, Kun Zhang, Wing-Leung Wong
Publikováno v:
Journal of Luminescence. 205:367-373
The molecular of scaffold of thiazole orange has a number of merits for being as a fluorescent dye with tailor-made structure advancement for many useful applications. Structural modification based on 1-methylquinolinium moiety of thiazole orange is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5066ed2b5f9faafb596857a0cace237
https://doi.org/10.1016/j.jlumin.2018.09.057
https://doi.org/10.1016/j.jlumin.2018.09.057
Autor:
Wei Long, Kun Zhang, Cheuk Fai Stephen Chow, Ying Li, Wing-Leung Wong, Du Xian, Jin-Qiang Hou, Sen-Yuan Cai, Xuan-He Huang, Leonard G. Luyt, Yu-Jing Lu
Publikováno v:
Dyes and Pigments. 159:449-456
New fluorescent dyes derivatized on a classical thiazole orange framework are able to show unexpectedly strong interaction signal and unusual binding selectivity with different structures of nucleic acid, particularly when bound with double-stranded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a74f10216bfd42b8e785f688b4c5625
https://doi.org/10.1016/j.dyepig.2018.07.008
https://doi.org/10.1016/j.dyepig.2018.07.008
Autor:
Yu-Jing Lu, Cheuk Fai Stephen Chow, Zheng Yuanyuan, Guo Xiaolu, Jin-Qiang Hou, Wing-Leung Wong, Miao-Han Xu, Ning Sun, Wang Cong, Yan Yan, Kun Zhang, Leonard G. Luyt
Publikováno v:
Sensors and Actuators B: Chemical. 250:543-551
Thiazole orange (TO) stains most nucleic acids giving strong fluorescence signal non-specifically. To resolve the poor discriminating ability of TO among tertiary structures of DNAs, a planar and rotatable π–conjugated small molecule designed by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a01b0191f62d15ba3b9affb4caa6296
https://doi.org/10.1016/j.snb.2017.05.018
https://doi.org/10.1016/j.snb.2017.05.018
Publikováno v:
RSC advances. 8(36)
A symmetric ligand is synthesized composed of a core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e8a1aaa474f65406651a9e9c40fa9ba
https://pubmed.ncbi.nlm.nih.gov/35543993
https://pubmed.ncbi.nlm.nih.gov/35543993
Autor:
Hui-Yun Liu, Jia-Heng Tan, Zhi-Shu Huang, Ding Li, Chan Shan, Ai-Chun Chen, Shuo-Bin Chen, Lian-Quan Gu, Jin-Qiang Hou, Jing Lin, Tian-Miao Ou
Publikováno v:
Nucleic Acids Research
c-MYC is an important oncogene that is considered as an effective target for anticancer therapy. Regulation of this gene's transcription is one avenue for c-MYC-targeting drug design. Direct binding to a transcription factor and generating the interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a556af0b1e5983fef725f54efcfb6f57
https://doi.org/10.1093/nar/gkv641
https://doi.org/10.1093/nar/gkv641
Autor:
Mingfeng Yu, Shudong Wang, Jingfeng Lu, Peng Li, Muhammed H. Rahaman, Ahmed Abdelaziz, Sunita K.C. Basnet, Bich Thuy Le, Theodosia Teo, Jin-Qiang Hou, Robert W. Milne, Hugo Albrecht, Sarah Diab, Ben Noll
Publikováno v:
European journal of medicinal chemistry. 139
The discovery of novel anti-AML therapeutic agents is urgently needed, but the complex heterogeneity of the disease has so far hampered the development of a curative treatment. FLT3 inhibitors have shown therapeutic potential in clinical trials; but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595f395731c8b07b5e911a3e187a1d52
https://pubmed.ncbi.nlm.nih.gov/28863357
https://pubmed.ncbi.nlm.nih.gov/28863357
Publikováno v:
Journal of Chemical Physics; 4/7/2008, Vol. 128 Issue 13, p134707, 4p, 1 Diagram, 1 Graph
Autor:
Zhi-Shu Huang, Hai-Bin Luo, Shuo-Bin Chen, Lian-Quan Gu, Ding Li, Jin-Qiang Hou, Jia-Heng Tan
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:1355-1368
G-quadruplexes are higher-order DNA and RNA structures formed from guanine-rich sequences. These structures have recently emerged as a new class of potential molecular targets for anticancer drugs. An understanding of the three-dimensional interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ed180e4fe44860d1ebfb5b2c8bdca6
https://doi.org/10.1007/s10822-012-9619-1
https://doi.org/10.1007/s10822-012-9619-1