Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jin-Keon Pai"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:579-584
Two novel phospholipase D (PLD) inhibitors, Sch 53823 (1) and Sch 53825 (2), were isolated from a fungal culture. The acetylated derivatives, Sch 53827 (3) and Sch 53829 (4), were prepared for the purpose of structure determination. The extensive NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9abd7735e71c50e98718c048a6f97d
https://doi.org/10.1016/0960-894x(96)00074-1
https://doi.org/10.1016/0960-894x(96)00074-1
Autor:
Mahesh Patel, Arthur King, David W. Phife, Mohindar S. Puar, Stephen J. Coval, Ho-Sam Ahn, Michael A. Conover, Robert E. Burrier, Ronald Mierzwa, George Boykow, Shirley A. Pomponi, Jin-Keon Pai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:605-610
Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43771b2f2d74978d600936df765a5925
https://doi.org/10.1016/0960-894x(95)00081-4
https://doi.org/10.1016/0960-894x(95)00081-4
Publikováno v:
Journal of Biological Chemistry. 269:26842-26847
The mechanism of phospholipase D (PLD) activation by platelet-derived growth factor (PDGF) was examined using a NIH 3T3 fibroblast cell line (3T3-gamma 1) that stably overexpresses PLC-gamma 1 isozyme. Immunoblot analysis revealed that 3T3-gamma 1 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e660fc537ec8373adbe27e50defc5bf0
https://doi.org/10.1016/s0021-9258(18)47096-2
https://doi.org/10.1016/s0021-9258(18)47096-2
Autor:
Min Chu, Imbi Truumees, Vincent P. Gullo, Pradip R. Das, Mohindar S. Puar, Mahesh Patel, Jin-Keon Pai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1539-1542
Sch 49211 ( 2 and Sch 49212 9 3 have been isolated from the fermentation of the fungus Nattrasia mangiferae. The structures of 2 and 3 were determined by analysis of NMR spectroscopic data. Both 2 and 3 exhibit inhibitory activity (IC 50 = 11 and 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e33136d7ae7a8d431ce09041faba4fa
https://doi.org/10.1016/s0960-894x(01)80529-1
https://doi.org/10.1016/s0960-894x(01)80529-1
Autor:
Ivan King, Vincent P. Gullo, Mohindar S. Puar, Mahesh Patel, Min Chu, Christine Blood, Imbi Truumees, Jin-Keon Pai
Publikováno v:
Tetrahedron Letters. 35:1343-1346
Sch 49210, Sch 53514 and Sch 53516 have been isolated from a fungal culture, and identified by analysis of 2D NMR data. Two diacetylation derivatives Sch 53515 and Sch 53517 have been synthesized. These compounds demonstrate inhibitory activity of ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef8929f44b2307ed7bfb70386bde2dc
https://doi.org/10.1016/s0040-4039(00)76213-7
https://doi.org/10.1016/s0040-4039(00)76213-7
Autor:
Mohindar S. Puar, Robert E. Burrier, David W. Phife, Stephen J. Coval, Michael A. Conover, Ronald Mierzwa, Ho-Sam Ahn, Mahesh Patel, Arthur King, George Boykow, Shirley A. Pomponi, Jin-Keon Pai
Publikováno v:
ChemInform. 26
Wiedendiol-A and -B, novel sesquiterpene-hydroquinones which inhibit cholesteryl ester transfer protein (CETP), have been isolated from the marine sponge Xestospongia wiedenmayeri. Additional related marine natural products were also evaluated for CE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b8898151a55bec29ddf2caf58ae21e
https://doi.org/10.1002/chin.199531201
https://doi.org/10.1002/chin.199531201
Publikováno v:
Journal of Biological Chemistry. 267:9826-9830
Rat 6 fibroblasts that stably overexpress cDNA for the beta 1 isozyme of protein kinase C (PKC3 cells) were used to determine the effect of protein kinase C (PKC) overexpression on hormonal stimulation of phospholipid hydrolysis. In control Rat 6 cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3cc6478e0abd64d82c61a4b2e1e65e9
https://doi.org/10.1016/s0021-9258(19)50168-5
https://doi.org/10.1016/s0021-9258(19)50168-5
Publikováno v:
Advances in Enzyme Regulation. 32:177-192
The binding of a variety of agonists to their receptors leads to the breakdown of membrane phospholipids and the formation of intracellular second messengers. Hydrolysis of inositol phospholipids by phospholipase C results in the formation of two sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b72dbae29e29a731e56af671b4f14ef
https://doi.org/10.1016/0065-2571(92)90016-s
https://doi.org/10.1016/0065-2571(92)90016-s
Publikováno v:
Proceedings of the National Academy of Sciences. 88:598-602
We are using a Rat-6 fibroblast cell line that stably overexpresses the beta 1 isozyme of protein kinase C (PKC) to study regulation of phospholipid hydrolysis by PKC. Stimulation of control (R6-C1) or overexpressing (R6-PKC3) cells with phorbol este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c045235baf9909b2836e4c417a366cd8
https://doi.org/10.1073/pnas.88.2.598
https://doi.org/10.1073/pnas.88.2.598
Autor:
Vinod R. Hegde, Ping Dai, Mahesh Patel, Pradip R. Das, M. S. Puar, Robert W. Bryant, Jin-Keon Pai, P. A. Cox
Publikováno v:
Journal of Natural Products. 60:537-539
Three flavonoid phospholipase A 2 (PLA 2 ) inhibitors were isolated from a MeOH extract of the bark of the Samoan medicinal plant Erythrina variegata. Two of these compounds, 4'-hydroxy-3',5'-diprenylisoflavonone (abyssinone V) (1) and 3,9-dihydroxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b507a3c54c4a4fee6a1648605285fe32
https://doi.org/10.1021/np960533e
https://doi.org/10.1021/np960533e