Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jin Won Cho"'
Autor:
Tae Hyun Kweon, Hyeryeon Jung, Jeong Yeon Ko, Jingu Kang, Wonyoung Kim, Yeolhoe Kim, Han Byeol Kim, Eugene C. Yi, Nam-On Ku, Jin Won Cho, Won Ho Yang
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114163- (2024)
Summary: Dysregulation of O-GlcNAcylation has emerged as a potential biomarker for several diseases, particularly cancer. The role of OGT (O-GlcNAc transferase) in maintaining O-GlcNAc homeostasis has been extensively studied; nevertheless, the regul
Externí odkaz:
https://doaj.org/article/096cededcc15463f80c3492994276abe
Autor:
Hye In Cho, Sora Jo, Min Seong Kim, Han Byeol Kim, Xingzhe Liu, Yanhua Xuan, Jin Won Cho, Yeun Kyu Jang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The dosage-dependent recruitment of RNA polymerase II (Pol II) at the promoters of genes related to neurodevelopment and stem cell maintenance is required for transcription by the fine-tuned expression of SET-domain-containing protein 5 (SET
Externí odkaz:
https://doaj.org/article/45c90b0c58c7471290617c917f82a341
Autor:
Won Ho Yang, Peter V. Aziz, Douglas M. Heithoff, Yeolhoe Kim, Jeong Yeon Ko, Jin Won Cho, Michael J. Mahan, Markus Sperandio, Jamey D. Marth
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107883- (2023)
Summary: The colonic mucosal barrier protects against infection, inflammation, and tissue ulceration. Composed primarily of Mucin-2, proteolytic erosion of this barrier is an invariant feature of colitis; however, the molecular mechanisms are not wel
Externí odkaz:
https://doaj.org/article/d157d4c503524879adbc519f7beab15b
Autor:
Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O
Externí odkaz:
https://doaj.org/article/4fe9f76e86f5401db95a5a9f89b10938
Autor:
Pyunggang Kim, Jinah Park, Dong-Joon Lee, Seiya Mizuno, Masahiro Shinohara, Chang Pyo Hong, Yealeen Jeong, Rebecca Yun, Hyeyeon Park, Sujin Park, Kyung-Min Yang, Min-Jung Lee, Seung Pil Jang, Hyun-Yi Kim, Seung-Jun Lee, Sun U. Song, Kyung-Soon Park, Mikako Tanaka, Hayato Ohshima, Jin Won Cho, Fumihiro Sugiyama, Satoru Takahashi, Han-Sung Jung, Seong-Jin Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Controlling fate decision of mesenchymal stromal cells (MSC) is important for their clinical application. Here the authors demonstrate that TGF-β-induced Mast4 suppression and Wnt-mediated Mast4 stabilization regulate MSC differentiation into cartil
Externí odkaz:
https://doaj.org/article/772a40cc1ab9487eb361fa1e59c50fe2
Autor:
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueiras
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of
Externí odkaz:
https://doaj.org/article/9769f87dfa1c4d5b90bfa5688f97fb4c
Autor:
Eun Ran Kim, So Ra Kim, Wonhee Cho, Sang-Guk Lee, Soo Hyun Kim, Jin Hee Kim, Eunhye Choi, Jeong-Ho Kim, Je-Wook Yu, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee, Jin Won Cho, Justin Y. Jeon, Yong-ho Lee
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A ketogenic diet (KD) is known to have beneficial health effects. Various types of KD interventions have been applied to manage metabolic syndrome based on modification of diet parameters such as duration of intervention, macronutrient components, an
Externí odkaz:
https://doaj.org/article/7144e43b77ac40cba3d9b914f3b2b289
Autor:
So Ra Kim, Sang-Guk Lee, Soo Hyun Kim, Jin Hee Kim, Eunhye Choi, Wonhee Cho, John Hoon Rim, Inhwa Hwang, Chan Joo Lee, Minyoung Lee, Chang-Myung Oh, Justin Y. Jeon, Heon Yung Gee, Jeong-Ho Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee, Je-Wook Yu, Jin Won Cho, Jung-Sun Kim, Yong-ho Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
SGLT2 inhibitors, a class of type 2 diabetes medication, reduce cardiovascular events in patients beyond expectation from blood sugar control. Here the authors report a randomized controlled trial showing that SGLT2 inhibitors reduce inflammasome act
Externí odkaz:
https://doaj.org/article/348deff1539f49598275f21f38cec615
Publikováno v:
Cancers, Vol 14, Iss 12, p 3013 (2022)
The balance between cellular proliferation and apoptosis and the regulation of cell differentiation must be established to maintain tissue homeostasis. These cellular responses involve the kinase cascade-mediated Hippo pathway as a crucial regulator.
Externí odkaz:
https://doaj.org/article/64adbfac9c5d4a798c31eff468e3476c
Autor:
Kwang Seob Lee, Yongin Cho, Hongkyung Kim, Hyunkyeong Hwang, Jin Won Cho, Yong-ho Lee, Sang-Guk Lee
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1216 (2022)
Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease, yet cost-effective and non-invasive diagnostic tools to monitor the severity of the disease are lacking. We aimed to investigate the metabolomic changes in NAFLD a
Externí odkaz:
https://doaj.org/article/56c1d6c4d7c64099beef5aadcb00eff8