Výsledky vyhledávání - "Jin T. E. Lim"

Sulindac Sulfide and Exisulind Inhibit Expression of the Estrogen and Progesterone Receptors in Human Breast Cancer Cells

Autor: Andrew K. Joe, Jin T. E. Lim, Muneyuki Masuda, Masahito Shimizu, I. Bernard Weinstein, Masumi Suzui

Publikováno v: Clinical Cancer Research. 12:3478-3484

In previous studies, we found that sulindac sulfide and exisulind (sulindac sulfone, Aptosyn) cause growth inhibition, arrest cells in the G1 phase of the cell cycle, and induce apoptosis in human breast cancer cell lines. These effects were associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96afe55ad4c42be67c034bc89ced25b0
https://doi.org/10.1158/1078-0432.ccr-05-2051

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Synergistic Effects of Acyclic Retinoid and OSI-461 on Growth Inhibition and Gene Expression in Human Hepatoma Cells

Autor: Julia H. Hayes, Kyriakos P. Papadopoulos, Masumi Suzui, Atsuko Deguchi, I. Bernard Weinstein, Jin T. E. Lim, Masahito Shimizu, Danhua Xiao

Publikováno v: Clinical Cancer Research. 10:6710-6721

Hepatoma is one of the most frequently occurring cancers worldwide. However, effective chemotherapeutic agents for this disease have not been developed. Acyclic retinoid, a novel synthetic retinoid, can reduce the incidence of postsurgical recurrence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac3e4dfd80fdd89306251abc36914ab
https://doi.org/10.1158/1078-0432.ccr-04-0659

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Acyclic retinoid activates retinoic acid receptor β and induces transcriptional activation of p21CIP1 in HepG2 human hepatoma cells

Autor: Masumi Suzui, Masahito Shimizu, Muneyuki Masuda, Jin T. E. Lim, Naoki Yoshimi, I. Bernard Weinstein

Publikováno v: Molecular Cancer Therapeutics. 3:309-316

Acyclic retinoid (ACR), a novel synthetic retinoid, has recently been demonstrated by us to inhibit the in vitro growth of human hepatoma cells, and this effect was associated with decreased expression of cell cycle-related molecules. These results,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bc1266035628c895c9c81dc626c1fcf
https://doi.org/10.1158/1535-7163.309.3.3

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Growth Inhibitory Activity of Extracts and Purified Components of Black Cohosh on Human Breast Cancer Cells

Autor: Edward J. Kennelly, Danhua Xiao, Thomas Pertel, Fredi Kronenberg, Masahito Shimizu, Jin T. E. Lim, Masumi Suzui, I. Bernard Weinstein, Colette Seter, Paiboon Nuntanakorn, Linda Saxe Einbond

Publikováno v: Breast Cancer Research and Treatment. 83:221-231

The purpose of this study was to determine whether black cohosh contains constituents that inhibit the growth of human breast cancer cells, and therefore might eventually be useful in the prevention or treatment of breast cancer. Black cohosh rhizome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb619ecce73ddab942e8e94e0f6a1dd
https://doi.org/10.1023/b:brea.0000014043.56230.a3

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Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction

Autor: Atsuko Deguchi, Jin T. E. Lim, Masumi Suzui, I. Bernard Weinstein, Jae-Won Soh, Muneyuki Masuda

Publikováno v: Journal of Experimental Therapeutics and Oncology. 2:350-359

In a recent study on head and neck squamous cell carcinoma (HNSCC) cells we found that epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, inhibited activation of the epidermal growth factor receptor (EGFR) and rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7224fc7d47a331b146de53de898ad6f
https://doi.org/10.1046/j.1359-4117.2002.01062.x

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Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

Autor: Paul H. Gross, I. Bernard Weinstein, Gerhard Sperl, Han Li, Gary A. Piazza, E. K.-H. Han, Thomas Delohery, Rifat Pamukcu, Klaus Brendel, Hirofumi Yamamoto, Tyler S. Finn, Ralph Buttyan, Jin T. E. Lim

Publikováno v: Biochemical Pharmacology. 58:1097-1107

We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac sulfone (exisulind, Prevatec), and a novel highly potent analog of exisulind (CP248) on a series of human prostate epitheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0094e1f860ac8f1aa2efe52d5d295d4
https://doi.org/10.1016/s0006-2952(99)00200-2

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(-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells

Autor: I. Bernard Weinstein, Jin T. E. Lim, Hisataka Moriwaki, Levy Kopelovich, Masahito Shimizu, Atsuko Deguchi

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 11(7)

Purpose: (−)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) and multiple downstream signaling pathways in cancer cell lines. In this study we co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23ce137cfbf3dfe1f01dd157fe7a54a
https://pubmed.ncbi.nlm.nih.gov/15814656

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Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cells

Autor: Masumi, Suzui, Masahito, Shimizu, Muneyuki, Masuda, Jin T E, Lim, Naoki, Yoshimi, I Bernard, Weinstein

Publikováno v: Molecular cancer therapeutics. 3(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d129e272d79763047d2614b1b21e1d13
https://pubmed.ncbi.nlm.nih.gov/15026551

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Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells

Autor: I. Bernard Weinstein, Masumi Suzui, Masahito Shimizu, Jin T. E. Lim, Atsuko Deguchi

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(3)

We described recently the growth inhibitory effects of the novel compound acyclic retinoid (ACR) in human hepatoma cell lines (M. Suzui et al., Cancer Res., 62: 3997–4006, 2002). In this study we examined the cellular and molecular effects of ACR o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7eba20c53e65a25be24d93704d02f0c
https://pubmed.ncbi.nlm.nih.gov/14871993

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Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells

Autor: Jin T E, Lim, Gary A, Piazza, Rifat, Pamukcu, W Joseph, Thompson, I Bernard, Weinstein

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(13)

In recent studies, we found that sulindac sulfide (SS), exisulind, CP248, and CP461 induce growth inhibition and apoptosis in a series of human prostate cancer cell lines, irrespective of cyclooxygenase expression, p53 mutations, or bcl-2 overexpress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41b940da687a52438570736bd8eb3d51
https://pubmed.ncbi.nlm.nih.gov/14581372

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