Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jin Shimakura"'
Autor:
Tetsu Saito, Ken-ichi Yamamoto, Hideki Harada, Kazuhiro Nishimiya, Masanobu Nishidate, Hiroko Shigemizu, Nana Kawasaki, Tsutomu Hashimoto, Kazuhiko Sonehara, Itadaki Yamaguchi, Akiko Ishii-Watabe, Tatsuki Nomura, Jin Shimakura, Kenta Kadotsuji, Takahiro Nakamura, Jun Hosogi, Kyoko Minoura, Shingo Niimi, Tamiki Mori, Maiko Adachi
Publikováno v:
Drug metabolism and pharmacokinetics. 33(2)
This study was undertaken to evaluate the performance of anti-drug antibody (ADA) assays constructed by each participating company using common samples including ADA, drug and human serum. The ADA assays constructed by each company showed good sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c9c6b2994118c31260e25d0dca2834
https://pubmed.ncbi.nlm.nih.gov/29610053
https://pubmed.ncbi.nlm.nih.gov/29610053
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G395-G402
The intestinal H+/peptide cotransporter 1 (PEPT1) plays important roles as a nutrient and drug transporter. Previously, we reported that rat intestinal PEPT1 showed a diurnal rhythm and that this rhythm is closely related to the feeding schedule. Fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa140dd68b7b23540c8db7239dba429
https://doi.org/10.1152/ajpgi.90317.2008
https://doi.org/10.1152/ajpgi.90317.2008
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 291:G851-G856
We previously demonstrated that starvation markedly increased the amount of mRNA and protein levels of the intestinal H+/peptide cotransporter (PEPT1) in rats, leading to altered pharmacokinetics of the PEPT1 substrates. In the present study, the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1083fb67bf4d5e8155cf2b233ac1bc88
https://doi.org/10.1152/ajpgi.00171.2006
https://doi.org/10.1152/ajpgi.00171.2006
Publikováno v:
Biochemical Pharmacology. 71:1581-1588
H(+)/peptide cotransporter 1 (PEPT1, SLC15A1) localized at the brush-border membranes of intestinal epithelial cells plays important roles in the intestinal absorption of small peptides and a variety of peptidemimetic drugs. We previously demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500b59ebd5fe3cbbfb506e26a0e0b87e
https://doi.org/10.1016/j.bcp.2006.03.001
https://doi.org/10.1016/j.bcp.2006.03.001
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G471-G477
H+-coupled peptide transporter 1 (PEPT1, SLC15A1) localized at the brush-border membranes of intestinal epithelial cells plays an important role in the intestinal absorption of small peptides and a variety of peptidemimetic drugs. PEPT1 is regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6c66ac58e1fe02e80e902f3cd18b4e
https://doi.org/10.1152/ajpgi.00025.2005
https://doi.org/10.1152/ajpgi.00025.2005
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 28:67-72
In vitro metabolism studies were conducted to assess drug-drug interactions between perospirone, an antipsychotic agent, and concomitantly administered drugs--biperiden, flunitrazepam, haloperidol, and diazepam--using human liver microsomes. The meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad292bf20a9a0216468b3fd885361a4
https://doi.org/10.1007/bf03190869
https://doi.org/10.1007/bf03190869
Publikováno v:
Xenobiotica. 32:399-409
1. The disposition of SM-11355, an anticancer platinum complex for hepatocellular carcinoma, was investigated in dog by measuring platinum (Pt) and radioactivity levels following intrahepatic arterial administration of (14)C-SM-11355 suspended in Lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c418ba74568e0a97068086d28dfa2bf3
https://doi.org/10.1080/00498250110111999
https://doi.org/10.1080/00498250110111999
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 22:25-33
Metabolism of 4-[1-(2-fluoro-4-biphenylyl)ethyl]-2-methylaminothiazole (SM-8849), a novel immunomodulatory agent, in rats was investigated. By co-chromatography with authentic samples, desmethylated (SM-8800) p-hydroxylated (SL-5512) and desmethylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccff3664beeeeebe6b63f80028f77f4
https://doi.org/10.1007/bf03189781
https://doi.org/10.1007/bf03189781
Autor:
Setsuko Komuro, Jin Shimakura, Toshifumi Fukuoka, Atsushi Kitamura, Masashi Yabuki, Hiroyuki Asano, Minoru Nakano
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 36(4)
Miriplatin is an anticancer platinum complex for treatment of hepatocellular carcinomas by intra-hepatic arterial injection suspended in an iodinated ethyl ester of fatty acids from poppy seed oil as a carrier. Effects of liver and kidney function on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf612f9aec210f1c552f49fd657ce6d1
https://pubmed.ncbi.nlm.nih.gov/21739189
https://pubmed.ncbi.nlm.nih.gov/21739189
Autor:
Ken-ichi Inui, Jin Shimakura, Tomoyuki Mizuno, Toshiya Katsura, Masahiro Tsuda, Tomohiro Terada
Publikováno v:
Molecular pharmacology. 75(6)
Multidrug and toxin extrusion 1 (MATE1/SLC47A1) is important for excretion of organic cations in the kidney and liver, where it is located on the luminal side. Although its functional and regulatory characteristics have been clarified, its pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0b6bad9486b4faaa0ec52dc989ebde
https://pubmed.ncbi.nlm.nih.gov/19332510
https://pubmed.ncbi.nlm.nih.gov/19332510