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pro vyhledávání: '"Jin Ri Hong"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4146-4149
A novel series of arylsulfonylaminomethyl-3-(1-phenyl-5-isopropyl)pyrazoles was evaluated for serotonin receptor subtype 6 (5-HT6R) antagonistic effects in vitro. We also investigated their neuropathic pain-alleviating effects in vivo using a rat spi
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4677-4685
A novel series of fused-benzensulfonamide 2-N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives was designed and synthesized as metabolically stable T-type calcium channel inhibitors. Several compounds, 9, 10, and 17, displayed potent T
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(17)
A novel series of arylsulfonylaminomethyl-3-(1-phenyl-5-isopropyl)pyrazoles was evaluated for serotonin receptor subtype 6 (5-HT
Autor:
Sungjin Cho, Vani Nelamane Devegowda, Eun Jeong Lim, Ghilsoo Nam, Jin-Ri Hong, Hyunah Choo, Gyochang Keum, Hyewon Rhim
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(16)
A novel series of 3-arylsulfonylamino-5,6-dihydro-6-substituted-1H-pyrazolo[3,4-c]pyridine-7-ones was designed and synthesized as 5-HT6 ligands. Among the derivatives synthesized, the lead compound, 12b, having piperidine functionality at the 6-posit