Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Jin Peng Sun"'
Autor:
Shen-Ming Huang, Zhi-Zhen Huang, Lei Liu, Meng-Yao Xiong, Chao Zhang, Bo-Yang Cai, Ming-Wei Wang, Kui Cai, Ying-Li Jia, Jia-Le Wang, Ming-Hui Zhang, Yi-He Xie, Min Li, Hang Zhang, Cheng-Hao Weng, Xin Wen, Zhi Li, Ying Sun, Fan Yi, Zhao Yang, Peng Xiao, Fan Yang, Xiao Yu, Lu Tie, Bao-Xue Yang, Jin-Peng Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Urea’s transmembrane transport through urea transporters (UT) is a fundamental physiological behavior for life activities. Here, we present 11 cryo-EM structures of four UT members in resting states, urea transport states, or inactive stat
Externí odkaz:
https://doaj.org/article/45cc969e094144449570478a54b118c0
Autor:
Xuan Zhang, Guibing Liu, Ya-Ni Zhong, Ru Zhang, Chuan-Cheng Yang, Canyang Niu, Xuanyu Pu, Jingjing Sun, Tianyao Zhang, Lejin Yang, Chao Zhang, Xiu Li, Xinyuan Shen, Peng Xiao, Jin-Peng Sun, Weimin Gong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Histamine is a biogenic amine that is critical in various physiological and pathophysiological processes, including but not limited to allergic reactions, wakefulness, gastric acid secretion and neurotransmission. Here, we determine 9 cryo-e
Externí odkaz:
https://doaj.org/article/caa1e1b401bc41a4a39457297f5ff478
Autor:
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao‐Kun Zang, Dan‐Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin‐Peng Sun, Yan Zhang, Zhong Chen
Publikováno v:
Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
Abstract G‐protein‐coupled receptors (GPCRs) transmit downstream signals predominantly via G‐protein pathways. However, the conformational basis of selective coupling of primary G‐protein remains elusive. Histamine receptors H2R and H3R coupl
Externí odkaz:
https://doaj.org/article/8143a64c78c74d9eab3c2726cae8a215
Autor:
Letian Song, Shenghua Gao, Bing Ye, Mianling Yang, Yusen Cheng, Dongwei Kang, Fan Yi, Jin-Peng Sun, Luis Menéndez-Arias, Johan Neyts, Xinyong Liu, Peng Zhan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 87-109 (2024)
The main protease (Mpro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle. The covalent Mpro inhibitor nirmatrelvir (in combination with ritonavir, a pharmacokinetic enhan
Externí odkaz:
https://doaj.org/article/3f51f2f2ddc7422491491f1bb580fa8a
Autor:
Lulu Guo, Yumu Zhang, Guoxing Fang, Lu Tie, Yuming Zhuang, Chenyang Xue, Qi Liu, Minghui Zhang, Kongkai Zhu, Chongzhao You, Peiyu Xu, Qingning Yuan, Chao Zhang, Lei Liu, Naikang Rong, Shengxuan Peng, Yuan Liu, Chuanzheng Wang, Xin Luo, Zongyao Lv, Dongwei Kang, Xiao Yu, Cheng Zhang, Yi Jiang, Xinzhong Dong, Jiuyao Zhou, Zhongmin Liu, Fan Yang, H. Eric Xu, Jin-Peng Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 and MRGPRX1-Gq trimers in complex w
Externí odkaz:
https://doaj.org/article/760d907008f24e78b84b2534b10f2648
Autor:
Xiu Li, Xuan Zhang, Xin Wen, Daolai Zhang, Changxiu Qu, Xinyi Miao, Wenkai Zhang, Ru Zhang, Guibing Liu, Peng Xiao, Jin-Peng Sun, Weimin Gong
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113893- (2024)
Summary: Prostaglandin F2α (PGF2α) and thromboxane A2 (TXA2) are endogenous arachidonic acid metabolites, modulating diverse physiological processes including inflammation and cardiovascular homeostasis through activating PGF2α receptor (FP) and T
Externí odkaz:
https://doaj.org/article/c4f758df63c04704be776001aedbcc06
Autor:
Huang Wang, Haibo Du, Rui Ren, Tingting Du, Lin Lin, Zhe Feng, Dange Zhao, Xiaoxi Wei, Xiaoyan Zhai, Hongyang Wang, Tingting Dong, Jin-Peng Sun, Hao Wu, Zhigang Xu, Qing Lu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
In this work, the authors demonstrate that LLPS of the quaternary USH2 protein complex initiates the formation of stereociliary ankle link condensates, providing insights into the pathogenesis of deafness.
Externí odkaz:
https://doaj.org/article/394cc12e45e1465a9e42bef6d382f4c1
Autor:
Ying Guan, Hai‐Bo Du, Zhao Yang, Yu‐Zhu Wang, Rui Ren, Wen‐Wen Liu, Chao Zhang, Jia‐Hai Zhang, Wen‐Tao An, Na‐Na Li, Xiao‐Xue Zeng, Jie Li, Yi‐Xiao Sun, Yan‐Fei Wang, Fan Yang, Jun Yang, Wei Xiong, Xiao Yu, Ren‐Jie Chai, Xiao‐Ming Tu, Jin‐Peng Sun, Zhi‐Gang Xu
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract The ankle‐link complex (ALC) consists of USH2A, WHRN, PDZD7, and ADGRV1 and plays an important role in hair cell development. At present, its architectural organization and signaling role remain unclear. By establishing Adgrv1 Y6236fsX1 mu
Externí odkaz:
https://doaj.org/article/519a7db04fe14b859d23c268cf814014
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
Natural astaxanthin is a high-value ketone carotenoid mainly derived from Haematococcus pluvialis, which is an excellent antioxidant for human consumption. To study the role of lipids in accumulation of astaxanthin, the H. pluvialis-derived astaxanth
Externí odkaz:
https://doaj.org/article/714c3eb7aadf4f40b0ea387df3329003
Autor:
Meng-Lin Chao, Shanshan Luo, Chao Zhang, Xuechun Zhou, Miao Zhou, Junyan Wang, Chuiyu Kong, Jiyu Chen, Zhe Lin, Xin Tang, Shixiu Sun, Xinlong Tang, Hongshan Chen, Hong Wang, Dongjin Wang, Jin-Peng Sun, Yi Han, Liping Xie, Yong Ji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
S-nitrosylation can influence many pathophysiological processes. Here the authors show that the coupling efficiency of GNAI2 with CXCR5 is enhanced by S-nitrosylation of GNAI2, leading to Hippo-YAP dysfunction in endothelium, and plays a role in diab
Externí odkaz:
https://doaj.org/article/c0bb46778ed84b0794e0ffec175854d0