Anticancer Effect by Combined Treatment of Artemisia annua L. Polyphenols and Docetaxel in DU145 Prostate Cancer Cells and HCT116 Colorectal Cancer Cells

Autor: Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Ky Hyun Chung, Choong Won Kim, Won Sup Lee

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 2, Pp 1621-1634 (2024)

Docetaxel (DTX), a semi-synthetic analogue of paclitaxel (taxol), is known to exert potent anticancer activity in various cancer cells by suppressing normal microtubule dynamics. In this study, we examined how the anticancer effect of DTX is regulate

Externí odkaz: https://doaj.org/article/8c17ea6dcb5a499ea2b004ff5579990a

β-Lapachone Exerts Anticancer Effects by Downregulating p53, Lys-Acetylated Proteins, TrkA, p38 MAPK, SOD1, Caspase-2, CD44 and NPM in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells

Autor: Lee, Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim, Won Sup

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9867

β-lapachone (β-Lap), a topoisomerase inhibitor, is a naturally occurring ortho-naphthoquinone phytochemical and is involved in drug resistance mechanisms. Oxaliplatin (OxPt) is a commonly used chemotherapeutic drug for metastatic colorectal cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::0ba8449beb6429a06fe0b51e3aeb05d6

Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, β-Catenin, and MMP-9

Autor: Young Shin Ko, Eun Joo Jung, Se-il Go, Bae Kwon Jeong, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim, Hye Jung Kim, Won Sup Lee

Publikováno v: Molecules, Vol 25, Iss 8, p 1916 (2020)

Artemisia annua L. has been reported to show anti-cancer activities. Here, we determined whether polyphenols extracted from Artemisia annua L. (pKAL) exhibit anti-cancer effects on radio-resistant MDA-MB-231 human breast cancer cells (RT-R-MDA-MB-231

Externí odkaz: https://doaj.org/article/ba8022b45d624409a06c854dce903269

Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation

Autor: Eun Joo Jung, Anjugam Paramanantham, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Ky Hyun Chung, Choong Won Kim, Won Sup Lee

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1598, p 1598 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1598

The anticancer effects of natural phytochemicals are relevant to the modulation of cytokine signaling pathways in various cancer cells with stem-like properties as well as immune cells. The aim of this study was to elucidate a novel anticancer mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e4dcdbe31b98f40cafc7a558937d99
https://www.mdpi.com/1422-0067/23/3/1598

Doxorubicin-Resistant TNBC Cells Exhibit Rapid Growth with Cancer Stem Cell-like Properties and EMT Phenotype, Which Can Be Transferred to Parental Cells through Autocrine Signaling

Autor: Bae Kwon Jeong, Anjugam Paramanantham, Jin-Myung Jung, Eun Joo Jung, Gon-Sup Kim, Hye Jung Kim, Won Sup Lee, Hong-Soon Chan

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 22; Pages: 12438
International Journal of Molecular Sciences, Vol 22, Iss 12438, p 12438 (2021)
International Journal of Molecular Sciences

Emerging evidence suggests that breast cancer stem cells (BCSCs), and epithelial–mesenchymal transition (EMT) may be involved in resistance to doxorubicin. However, it is unlear whether the doxorubicin-induced EMT and expansion of BCSCs is related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f3e36c5efa9fcd62bcd5a0e90cd2c9