Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jin Mi Kang"'
Publikováno v:
Biomolecules
Volume 9
Issue 12
Volume 9
Issue 12
Neural stem cells (NSCs) differentiate into multiple cell types, including neurons, astrocytes, and oligodendrocytes, and provide an excellent platform to screen drugs against neurodegenerative diseases. Flavonoids exert a wide range of biological fu
Autor:
Hyae Jung Hyun, Dong Wook Kang, Young Ho Kim, Jeewoo Lee, Jiyoun Lee, Joon Hwan Lee, Hyun-Seok Hong, Dong-Gyu Jo, Jin-Mi Kang, Kwang-Hyun Choi, Hee-Jin Ha, Hee Kim, Sae Hee Kim, Hyuk-Min Kim, Jihyae Ann
Publikováno v:
Journal of Medicinal Chemistry. 61:396-402
We developed an orally active and blood-brain-barrier-permeable benzofuran analogue (8, MDR-1339) with potent antiaggregation activity. Compound 8 restored cellular viability from Aβ-induced cytotoxicity but also improved the learning and memory fun
Autor:
Jeewoo Lee, Robert Frank-Foltyn, Changhoon Kim, Gregor Bahrenberg, Sun Ok Kwon, Peter M. Blumberg, Hee-Jin Ha, Sun Choi, Thomas Christoph, Bernhard Lesch, Jihyae Ann, Sunho Lee, Thi Ngoc Lan Vu, Jin Mi Kang, Sanghee Yoon, Jin Ju Jeong, Nayeon Do, Hannelore Stockhausen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 48:128266
A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region anal
Autor:
Sun Ok Kwon, Jeewoo Lee, Hannelore Stockhausen, Bernhard Lesch, Jin Mi Kang, Jihyae Ann, Gregor Bahrenberg, Young Dong Yoo, Robert Frank-Foltyn, Thomas Christoph, Peter M. Blumberg, Hee-Jin Ha
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127548
A series of 1-indazol-3-(1-phenylpyrazol-5-yl)methyl ureas were investigated as hTRPV1 antagonists. The structure–activity relationship study was conducted systematically for both the indazole A-region and the 3-trifluoromethyl/t-butyl pyrazole C-r
Autor:
Hee-Jin Ha, Dong Wook Kang, Hyuk-Min Kim, Jin-Mi Kang, Jihyae Ann, Hyae Jung Hyun, Joon Hwan Lee, Sae Hee Kim, Hee Kim, Kwanghyun Choi, Hyun-Seok Hong, YoungHo Kim, Dong-Gyu Jo, Jiyoun Lee, Jeewoo Lee
Publikováno v:
Journal of Medicinal Chemistry; 1/11/2018, Vol. 61 Issue 1, p396-402, 7p