Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jin Li Luo"'
Autor:
Min Zhang, Aleksandra Bzura, Essa Y. Baitei, Zisen Zhou, Jake B. Spicer, Charlotte Poile, Jan Rogel, Amy Branson, Amy King, Shaun Barber, Tamihiro Kamata, Joanna Dzialo, James Harber, Alastair Greystoke, Nada Nusrat, Daniel Faulkner, Qianqian Sun, Luke Nolan, Jens C. Hahne, Molly Scotland, Harriet Walter, Liz Darlison, Bruno Morgan, Amrita Bajaj, Cassandra Brookes, Edward J. Hollox, Dominika Lubawska, Maymun Jama, Gareth Griffiths, Apostolos Nakas, Kudzayi Kutywayo, Jin-Li Luo, Astero Klampatsa, Andrea Cooper, Koirobi Halder, Peter Wells-Jordan, Huiyu Zhou, Frank Dudbridge, Anne Thomas, Catherine Jane Richards, Catrin Pritchard, Hongji Yang, Michael Barer, Dean A. Fennell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Malignant mesothelioma is a rare tumour caused by asbestos exposure that originates mainly from the pleural lining or the peritoneum. Treatment options are limited, and the prognosis is dismal. Although immune checkpoint blockade (ICB) can i
Externí odkaz:
https://doaj.org/article/d6df4246c4f7412cac62d653af0efa23
Autor:
Liz Darlison, Sean Ewings, Paul Taylor, Judith Cave, Gareth Griffiths, Zina Eminton, Dean Fennell, Charlotte Stuart, Daniel Griffiths, Abigail Morgan-Fox, Kayleigh Hill, Lucy Johnson, Kim Mallard, Mavis Nye, Sean Dulloo, Jin-Li Luo, Jake Spicer, Charlotte Poile, Aleksandra Bzura
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Background Malignant mesothelioma is a rapidly lethal cancer that has been increasing at an epidemic rate over the last three decades. Targeted therapies for mesothelioma have been lacking. A previous study called MiST1 (NCT03654833), evaluated the e
Externí odkaz:
https://doaj.org/article/14f488921ee9444996b83d190bc7f35b
Autor:
Sara Busacca, Qi Zhang, Annabel Sharkey, Alan G. Dawson, David A. Moore, David A. Waller, Apostolos Nakas, Carolyn Jones, Kelvin Cain, Jin-li Luo, Adriana Salcedo, Iris Chiara Salaroglio, Chiara Riganti, John Le Quesne, Tom John, Paul C. Boutros, Shu-Dong Zhang, Dean A. Fennell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, s
Externí odkaz:
https://doaj.org/article/6d5abf6e1ac14ad9997c92268bf3d48f
Autor:
Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The impact of intratumour heterogeneity on immune surveillance and clinical outcomes has not been adequately explored in malignant pleural mesothelioma (MPM). Here the authors analyse the influence of evolution on the survival and immune landscape of
Externí odkaz:
https://doaj.org/article/341b50055bdd45939a6f7909af185de3
Publikováno v:
Chinese Medicine, Vol 14, Iss 1, Pp 1-12 (2019)
Abstract Introduction Radix Salviae (Dan-shen in pinyin), a classic Chinese herb, has been extensively used to treat diabetic retinopathy in clinical practice in China for many years. However, the pharmacological mechanisms of Radix Salviae remain va
Externí odkaz:
https://doaj.org/article/fe9a67c10e064d6b82f895afd8b6afda
Autor:
Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G. Dawson, Apostolos Nakas, Sara Busacca, Annabel J. Sharkey, David Waller, Michael T. Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y. Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martinson, Jacqui A. Shaw, Catrin Pritchard, Tamihiro Kamata, Nathaniel Kuse, Lee Brannan, Pan De Philip Zhang, Hongji Yang, Gareth Griffiths, Gareth Wilson, Charles Swanton, Frank Dudbridge, Edward J. Hollox, Dean A. Fennell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f7108052398548089c329533761c1d7e
Autor:
Dean Fennell, Daniel Griffiths, Zina Eminton, Abigail Morgan-Fox, Kayleigh Hill, Theodora Nearchou, Lucy Johnson, Stephanie Harding, Charlotte Poile, Aleksandra Bzura, Jake Spicer, Mavis Nye, Judith Cave, Sarah Danson, Elizabeth Toy, Pooja Jain, Nicola Steele, Paul Shaw, Paul Taylor, Peter Szlosarek, Dionysis Papadatos-Pastos, Michael Lind, Sean Dulloo, Harman Saman, Amrita Bajaj, Jin-Li Luo, Liz Darlison, Gareth Griffiths
Publikováno v:
Lung Cancer. 178:S85-S86
Autor:
Nicholas Eastley, Aurore Sommer, Barbara Ottolini, Rita Neumann, Jin-Li Luo, Robert K. Hastings, Thomas McCulloch, Claire P. Esler, Jacqueline A. Shaw, Robert U. Ashford, Nicola J. Royle
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4483 (2020)
Soft tissue sarcomas (STS) are rare, malignant tumours with a generally poor prognosis. Our aim was to explore the potential of cell free DNA (cfDNA) and circulating tumour DNA (ctDNA) analysis to track non-metastatic STS patients undergoing attempte
Externí odkaz:
https://doaj.org/article/dc9fdf854272413d8366cbc380cc4b25
Publikováno v:
Chinese Medicine, Vol 14, Iss 1, Pp 1-12 (2019)
Introduction Radix Salviae (Dan-shen in pinyin), a classic Chinese herb, has been extensively used to treat diabetic retinopathy in clinical practice in China for many years. However, the pharmacological mechanisms of Radix Salviae remain vague. The
Autor:
Essa Y. Baitei, Min Zhang, Qianqian Sun, Jin-Li Luo, Philip Zhang, Tamihiro Kamata, James Harber, Aleksandra Bzura, Peter W. Jordan, Charlotte Poile, Alan Dawson, Apostolos Nakas, Cathy Richards, Hongji Yang, Ed Hollox, Dean A. Fennell
Publikováno v:
Cancer Research. 82:6086-6086
Background: Mesothelioma, a cancer caused by asbestos is lethal and lacks molecularly targeted therapy. The tumor suppressor NF2 constitutes a frequent, positively selected somatic alteration warranting synthetic lethal approaches to target this driv