Zobrazeno 1 - 10
of 380
pro vyhledávání: '"Jin Kui Yang"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2606-2614 (2024)
Cathepsin L (CTSL) is a promising therapeutic target for metabolic disorders. Current pharmacological interventions targeting CTSL have demonstrated potential in reducing body weight gain, serum insulin levels, and improving glucose tolerance. Howeve
Externí odkaz:
https://doaj.org/article/da7039a22cfa4c6bbf060a08010e244f
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Derived from enteroendocrine cells (EECs), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are pivotal incretin hormones crucial for blood glucose regulation. Medications of GLP-1 analogs and GLP-1 receptor
Externí odkaz:
https://doaj.org/article/1ad9a498b0a54c38801be287bfdc7e5a
Autor:
Ying Bai, Rui Li, Jun-Feng Hao, Lian-Wan Chen, Si-Tong Liu, Xi-Lin Zhang, Gregory Y. H. Lip, Jin-Kui Yang, Yi-Xi Zou, Hao Wang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Atrial fibrillation (AF) is associated with increased risk of stroke and mortality. It has been reported that the process of atrial fibrosis was regulated by β-catenin in rats with AF. However, pathophysiological mechanisms of th
Externí odkaz:
https://doaj.org/article/18f3d3c6c103462fbf8e8cbf3d60adc0
Autor:
Chen-Xia Li, Meng-Lin Fan, Bo-Wen Pang, Xing-Jian Zhou, Hong-Zi Zhang, Jing-Jing Zeng, Jin-Kui Yang, Shao-yong Xu
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Context/ObjectivesHydroxychoroquine has hypoglycemic effects and may reduce the risk of diabetes mellitus (DM). We determined the association between hydroxychoroquine use and the incidence of DM in a population-based cohort of pations with Rheumatic
Externí odkaz:
https://doaj.org/article/cd183396efe045b8b9ffc8450e1c2288
Hyperglycemia induced cathepsin L maturation linked to diabetic comorbidities and COVID-19 mortality
Autor:
Qiong He, Miao-Miao Zhao, Ming-Jia Li, Xiao-Ya Li, Jian-Min Jin, Ying-Mei Feng, Li Zhang, Wei Jin Huang, Fangyuan Yang, Jin-Kui Yang
Publikováno v:
eLife, Vol 13 (2024)
Diabetes, a prevalent chronic condition, significantly increases the risk of mortality from COVID-19, yet the underlying mechanisms remain elusive. Emerging evidence implicates Cathepsin L (CTSL) in diabetic complications, including nephropathy and r
Externí odkaz:
https://doaj.org/article/a9dc13b7423e4ba7b1dc7a0c847f4569
Autor:
Jing Lu, Ru-Xuan Zhao, Feng-Ran Xiong, Juan-Juan Zhu, Ting-Ting Shi, Ying-Chao Zhang, Gong-Xin Peng, Jin-Kui Yang
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101885- (2024)
Objective: Genome-scale CRISPR–Cas9 knockout coupled with single-cell RNA sequencing (scRNA-seq) has been used to identify function-related genes. However, this method may knock out too many genes, leading to low efficiency in finding genes of inte
Externí odkaz:
https://doaj.org/article/614360d6b4b7461a94a1a202764b2001
Autor:
Dong-Mei Zhou, Mengyuan Shen, Lv Ke, Zi-Lin Zhang, Kai-Zhe Zhang, Shenghui Zhang, Yanqing Wang, Hao-Ran Yang, Daoyuan Tang, Donghui Huang, Jin-Kui Yang, Huan Xu
Publikováno v:
Nanocomposites, Vol 8, Iss 1, Pp 24-33 (2022)
AbstractControlled incorporation of bioactive hydroxyapatite (HA) into poly(lactic acid) (PLA) signifies a promising approach to design and development of biomedical-adaptive materials. Here we unravel a microwave-assisted biomineralization approach
Externí odkaz:
https://doaj.org/article/d9dabda321254b31bf534e5453487122
Autor:
Xiao-Min Luo, Sin Man Lam, Yuan Dong, Xiao-Juan Ma, Cen Yan, Yue-Jie Zhang, Yu Cao, Li Su, Guotao Lu, Jin-Kui Yang, Guanghou Shui, Ying-Mei Feng
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Metabolomics analysis reveals that inosine monophosphate, a purine metabolite, promotes myelopoiesis and contributes to severe acute pancreatitis in db/db mice.
Externí odkaz:
https://doaj.org/article/a4be54771af5462ca261acd1e7f1a36d
Autor:
Xi Cao, Ming Lu, Rong-Rong Xie, Li-Ni Song, Wei-Li Yang, Zhong Xin, Guang-Ran Yang, Jin-Kui Yang
Publikováno v:
Endocrine Connections, Vol 11, Iss 7, Pp 1-9 (2022)
Aims: In this study, we determined the association between thyroid-stimulating hormone (TSH) and diabetic macular edema (DME) by assessing the prevalence and risk factors for DME in type 2 diabetes mellitus (T2DM) patients with different thyroid dysf
Externí odkaz:
https://doaj.org/article/be93d2f1259b475091d68c2b440779ff
Autor:
Miao-Miao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Shuo Liu, Guoliang Yin, Jing Lu, Qiong He, Ming-Jia Li, Ru-Xuan Zhao, Hao Wang, Weijin Huang, Changfa Fan, Lei Shuai, Zhiyuan Wen, Chong Wang, Xijun He, Qiuluan Chen, Banghui Liu, Xiaoli Xiong, Zhigao Bu, Youchun Wang, Fei Sun, Jin-Kui Yang
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence of variant strains with mutated S proteins has rendered many treatmen
Externí odkaz:
https://doaj.org/article/8787dfd1d6684523bb645431870ffa67