Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Jin Gohda"'
Autor:
Hideki Ogura, Jin Gohda, Xiuyuan Lu, Mizuki Yamamoto, Yoshio Takesue, Aoi Son, Sadayuki Doi, Kazuyuki Matsushita, Fumitaka Isobe, Yoshihiro Fukuda, Tai-Ping Huang, Takamasa Ueno, Naomi Mambo, Hiromoto Murakami, Yasushi Kawaguchi, Jun-ichiro Inoue, Kunihiro Shirai, Sho Yamasaki, Jun-Ichi Hirata, Satoshi Ishido
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cytotoxic T lymphocytes play important roles in the anti-viral immune response in COVID-19, and it is important to know how they contribute to disease outcome. Authors here identify a dominant SARS-CoV-2 M protein epitope, M198–206, and show that M
Externí odkaz:
https://doaj.org/article/70cc940bc6b1478b9b1f753fd415768c
Autor:
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi, Kensuke Hirasawa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, an
Externí odkaz:
https://doaj.org/article/85bc25bd97804d21b8ce1febd62737a6
Autor:
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The ongoing global vaccination program to prevent SARS-CoV-2 infection, the causative agent of COVID-19, has had significant success. However, recently, virus variants that can evade the immunity in a host achieved through vaccination have e
Externí odkaz:
https://doaj.org/article/79830b4f7f5f45f98ee50d504ba28a86
Autor:
Ahmed H. E. Hassan, Selwan M. El-Sayed, Mizuki Yamamoto, Jin Gohda, Takehisa Matsumoto, Mikako Shirouzu, Jun-ichiro Inoue, Yasushi Kawaguchi, Reem M. A. Mansour, Abtin Anvari, Abdelbasset A. Farahat
Publikováno v:
Viruses, Vol 15, Iss 5, p 1171 (2023)
Coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV and influenza A virus, require the host proteases to mediate viral entry into cells. Rather than targeting the continuously mutating viral proteins, targeting the conserved host-based entry mech
Externí odkaz:
https://doaj.org/article/e2aa8f63cdb24337bcdad9d160c7d589
Autor:
Mahmoud Kandeel, Mizuki Yamamoto, Byoung Kwon Park, Abdulla Al-Taher, Aya Watanabe, Jin Gohda, Yasushi Kawaguchi, Kentaro Oh-hashi, Hyung-Joo Kwon, Jun-ichiro Inoue
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion through co
Externí odkaz:
https://doaj.org/article/d8fad0c9c86e46dab57d04c7b02b163e
Autor:
Jin Gohda, Kazuo Suzuki, Kai Liu, Xialin Xie, Hiroaki Takeuchi, Jun-ichiro Inoue, Yasushi Kawaguchi, Takaomi Ishida
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing
Externí odkaz:
https://doaj.org/article/d37f295b182b40f49c519bc38e7232db
Autor:
Takeshi Into, Toshi Horie, Megumi Inomata, Jin Gohda, Jun-ichiro Inoue, Yukitaka Murakami, Shumpei Niida
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Autophagy, the processes of delivery of intracellular components to lysosomes, regulates induction of inflammation. Inducible macroautophagy degrades inflammasomes and dysfunctional mitochondria to downregulate inflammatory signals. Nonethel
Externí odkaz:
https://doaj.org/article/3c1b7fc1246b49098a73e79887c60ae9
Autor:
Mizuki Yamamoto, Maki Kiso, Yuko Sakai-Tagawa, Kiyoko Iwatsuki-Horimoto, Masaki Imai, Makoto Takeda, Noriko Kinoshita, Norio Ohmagari, Jin Gohda, Kentaro Semba, Zene Matsuda, Yasushi Kawaguchi, Yoshihiro Kawaoka, Jun-ichiro Inoue
Publikováno v:
Viruses, Vol 12, Iss 6, p 629 (2020)
Although infection by SARS-CoV-2, the causative agent of coronavirus pneumonia disease (COVID-19), is spreading rapidly worldwide, no drug has been shown to be sufficiently effective for treating COVID-19. We previously found that nafamostat mesylate
Externí odkaz:
https://doaj.org/article/ef95b75cf9ad4ebd9a09062a7a03ac9e
Autor:
Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-Ichiro Inoue
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006162 (2017)
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is crucial for the development of adult T-cell leukemia (ATL), a highly malignant CD4+ T cell neoplasm. Among the multiple aberrant Tax-induced effects on cellular processes, persistent a
Externí odkaz:
https://doaj.org/article/6243307cdf7e4072b1235417bf57ec8e
Autor:
Lijun Gu, Yang Han, Yijia Li, Ting Zhu, Xiaojing Song, Ying Huang, Feifei Yang, Shuo Guan, Jing Xie, Jin Gohda, Noriaki Hosoya, Ai Kawana-Tachikawa, Wenjun Liu, George Fu Gao, Aikichi Iwamoto, Taisheng Li, Takaomi Ishida
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134539 (2015)
In China, HIV-1-infected patients typically receive antiretroviral therapy (ART) that includes lamivudine (3TC) as a reverse-transcriptase inhibitor (RTI) (ART-3TC). Previous studies from certain developed countries have shown that, in ART-3TC, 3TC-r
Externí odkaz:
https://doaj.org/article/216c82b675544a2aa0cef6cdbd61c0b6