Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jin Cun Zhao"'
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103967- (2022)
Summary: The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tiss
Externí odkaz:
https://doaj.org/article/3bd7ffae8f2247688f0ee44156a0f2e9
Autor:
Hui Zhao, Na-Na Zhang, Suad Hannawi, Ai-Ru Zhu, Xiao-Chuan Xiong, Yi-Jiao Huang, Dan-Dan Yu, Can-Jie Chen, Jun Dai, Alaa Abuquta, Bo Ying, Jin-Cun Zhao, Cheng-Feng Qin
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/24cc734bcc1742759e49de13cbf19ad5
Autor:
Yang Peng, Shi-ying Chen, Zhao-ni Wang, Zi-qing Zhou, Jing Sun, Gui-an Zhang, Jia Li, Lei Wang, Jin-cun Zhao, Xiao Xiao Tang, De-Yun Wang, Nan-shan Zhong
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells (AECs) is a quick way to find novel treatments for COVID-19. Computational screening has found dicoumarol (DCM), a natural anticoagulant, to be a potential
Externí odkaz:
https://doaj.org/article/bb65deabefdb4c60a38fb520b7c28463
Autor:
Guang-Wei Feng, Zhong-Fang Wang, Peng He, Qin-Ying Lan, Ling Ni, Ya-Zheng Yang, Chen-Fei Wang, Ting-Ting Cui, Li-Li Huang, Yong-Qiang Yan, Zhi-Wei Jiang, Qing Yang, Bang-Wei Yu, Xi Han, Jing-Jing Chen, Shu-Yuan Yang, Lin Yuan, Ling-Yun Zhou, Ge Liu, Ke Li, Zhen Huang, Jin-Cun Zhao, Zhong-Yu Hu, Zhi-Qiang Xie
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
This was a phase 1 dose-escalation study of ZR202-CoV, a recombinant protein vaccine candidate containing a pre-fusion format of the spike (S)-protein (S-trimer) combined with the dual-adjuvant system of Alum/CpG. A total of 230 participants were scr
Externí odkaz:
https://doaj.org/article/6249aea6fd484c219325ab664a394757
Autor:
Wei-Li Yang, Qi Li, Jing Sun, Sia Huat Tan, Yan-Hong Tang, Miao-Miao Zhao, Yu-Yang Li, Xi Cao, Jin-Cun Zhao, Jin-Kui Yang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2442-2454 (2022)
Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be a promising therapeutic target for coronavirus disease 2019 (COVID-19). However, there is st
Externí odkaz:
https://doaj.org/article/43b61e7f3143492f9fcea1f4b0c8a5a3
Autor:
Peng-Le Guo, Ling-Hua Li, Wen-Li Li, Jin-Cun Zhao, Feng-Yu Hu, Fu-Chun Zhang, Wei-Ping Cai, Xiao-Ping Tang
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Myeloid-derived suppressor cells (MDSCs) play immunosuppressive roles in cancers and some infectious diseases; however, their role in dengue fever (DF) remains unknown. This study evaluated the clinical significance of MDSCs in DF
Externí odkaz:
https://doaj.org/article/bd47ee8bc2ea45bdac6388c35db852b6
Autor:
Meng-Li, Wu, Feng-Liang, Liu, Jing, Sun, Xin, Li, Jian-Ru, Qin, Qi-Hong, Yan, Xia, Jin, Xin-Wen, Chen, Yong-Tang, Zheng, Jin-Cun, Zhao, Jian-Hua, Wang
Publikováno v:
Zoological Research. 43:457-468
COVID-19 is an immune-mediated inflammatory disease caused by SARS-CoV-2 infection, the combination of anti-inflammatory and antiviral therapy is predicted to provide clinical benefits. We recently demonstrated that mast cells (MCs) are an essential
Autor:
Yang Peng, Zhao-Ni Wang, Shi-Ying Chen, Ai-Ru Xu, Zhang-Fu Fang, Jing Sun, Zi-Qing Zhou, Xiao-Tao Hou, Lai-Jian Cen, Jian-Juan Ma, Jin-Cun Zhao, Wei-Jie Guan, De-Yun Wang, Nan-Shan Zhong
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 322(5)
Accumulating evidence has confirmed that chronic obstructive pulmonary disease (COPD) is a risk factor for development of severe pathological changes in the peripheral lungs of patients with COVID-19. However, the underlying molecular mechanisms rema
Autor:
Wei-Li Yang, Qi Li, Jing Sun, Sia Huat Tan, Yan-Hong Tang, Miao-Miao Zhao, Yu-Yang Li, Xi Cao, Jin-Cun Zhao, Jin-Kui Yang
Publikováno v:
Computational and structural biotechnology journal. 20
Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be a promising therapeutic target for coronavirus disease 2019 (COVID-19). However, there is st
Autor:
Yin-Feng Kang, Cong Sun, Jing Sun, Chu Xie, Zhen Zhuang, Hui-Qin Xu, Zheng Liu, Yi-Hao Liu, Sui Peng, Run-Yu Yuan, Jin-Cun Zhao, Mu-Sheng Zeng
Publikováno v:
Nature communications. 13(1)
Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike protein. Here, we design a quadrivalent mosaic nanoparticle vaccine