Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Jin Choul Chai"'
Analysis of differentially expressed long non-coding RNAs in LPS-induced human HMC3 microglial cells
Autor:
Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Long non-coding RNAs (lncRNAs) are emerging as key modulators of inflammatory gene expression, but their roles in neuroinflammation are poorly understood. Here, we identified the inflammation-related lncRNAs and correlated mRNAs o
Externí odkaz:
https://doaj.org/article/4b447e2a22fc4c1f8c16d2053af8ccaf
Autor:
Hae In Choi, Ga Yeong An, Eunyoung Yoo, Mina Baek, Bert Binas, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The epigenetic reader, bromodomain-containing 4 (BRD4), is overexpressed in hepatocellular carcinoma (HCC), and BRD4 inhibition is considered as a new therapeutic approach. The BRD inhibitor JQ1 is known to inhibit the enrichment of BRD4 at
Externí odkaz:
https://doaj.org/article/bc8a76bc857d4853becf794c2332e593
Autor:
Hae In Choi, Ga Yeong An, Eunyoung Yoo, Mina Baek, Jin Choul Chai, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The proto-oncogene MYC is important for development and cell growth, however, its abnormal regulation causes cancer. Recent studies identified distinct enhancers of MYC in various cancers, but any MYC enhancer(s) in hepatocellular carcinoma
Externí odkaz:
https://doaj.org/article/9974e4b284874109b71368bdac5f8f4c
Autor:
Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O’Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii-Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin Qi, Ingo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations betwe
Externí odkaz:
https://doaj.org/article/490453d6665243aba801e3d3ea7f205f
Autor:
Hae In Choi, Ga Yeong An, Mina Baek, Eunyoung Yoo, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and poorly responsive cancers worldwide. Bromodomain and extraterminal (BET) inhibitors, such as JQ1 and OTX-015, inhibit BET protein binding to acetylated residues in histones. How
Externí odkaz:
https://doaj.org/article/2bf925a7b1f44275898bb8e721a341c7
Autor:
Mina Baek, Eunyoung Yoo, Hae In Choi, Ga Yeong An, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Microglia, resident macrophages of the brain that act as primary immune cells, play essential roles in innate immunity and neuroinflammatory pathologies. Microglial cells are rapidly activated in response to infection and inflammation/injury
Externí odkaz:
https://doaj.org/article/7a8daae75c6342daab790352521888f4
Autor:
Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266966 (2022)
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poor prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in HCC, suggesting epigenetic inhibition as a promising therapeutic approach. Indeed
Externí odkaz:
https://doaj.org/article/ab6ae6c231324f7ea66eb18c8a67e134
Autor:
Claudio A. Bravo, Simin Hua, Amy Deik, Jason Lazar, David B. Hanna, Justin Scott, Jin Choul Chai, Robert C. Kaplan, Kathryn Anastos, Octavio A. Robles, Clary B. Clish, Jorge R. Kizer, Qibin Qi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 4 (2020)
Background People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV‐associated LVDD may reflect both cardiomyocyte and systemic metabolic derangements, but the underlying pathways remain
Externí odkaz:
https://doaj.org/article/d70f232d2d9c4143a18ec1e3f93e9d29
Autor:
Amitabh Das, Sarder Arifuzzaman, Taeho Yoon, Sun Hwa Kim, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
Abstract Persistent microglial activation is associated with the production and secretion of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify neurodegenerative diseases. A novel synthetic histone 3 lysine 27 (H3
Externí odkaz:
https://doaj.org/article/f6fc55853b0b4d63a8c8340c456ed953
Autor:
Chanchal Mandal, Sun Hwa Kim, Jin Choul Chai, Seon Mi Oh, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149976 (2016)
Fetal alcohol spectrum disorder is a collective term representing fetal abnormalities associated with maternal alcohol consumption. Prenatal alcohol exposure and related anomalies are well characterized, but the molecular mechanism behind this phenom
Externí odkaz:
https://doaj.org/article/7130e29f7a4342039fc63c5e11aa02f3