Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jin Akagi"'
Autor:
Jin Akagi, Khashayar Khoshmanesh, Barbara Evans, Chris J Hall, Kathryn E Crosier, Jonathan M Cooper, Philip S Crosier, Donald Wlodkowic
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36630 (2012)
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in drug discovery and environmental toxicology. Drug discovery screens performed on zebrafish embryos mirror with a high level of accuracy the tests usually performed on ma
Externí odkaz:
https://doaj.org/article/49b60913e81f44478b8c6b9902c7b905
Autor:
Viktoria Andreeva, Donald Wlodkowic, Pamela C. Yelick, Sebastien G. M. Uzel, Adrian Devitt-Lee, Jin Akagi, Jean-François Paré, Dany S. Adams, Michael Levin
Publikováno v:
The Journal of Physiology. 594:3245-3270
Key points Xenopus laevis craniofacial development is a good system for the study of Andersen–Tawil Syndrome (ATS)-associated craniofacial anomalies (CFAs) because (1) Kcnj2 is expressed in the nascent face; (2) molecular-genetic and biophysical te
Autor:
Feng Zhu, Jin Akagi, Joanna Skommer, Dany S. Adams, Christopher J. Hall, Donald Wlodkowic, Philip S. Crosier, Yushi Huang, Michael Levin
Publikováno v:
Cytometry Part A. 85:921-932
Biotests performed on small vertebrate model organisms provide significant investigative advantages as compared with bioassays that employ cell lines, isolated primary cells, or tissue samples. The main advantage offered by whole-organism approaches
Autor:
Christopher J. Hall, Jin Akagi, Kathryn E. Crosier, Feng Zhu, Philip S. Crosier, Donald Wlodkowic
Publikováno v:
Cytometry Part A. 85:537-547
Transgenic zebrafish (Danio rerio) models of human diseases have recently emerged as innovative experimental systems in drug discovery and molecular pathology. None of the currently available technologies, however, allow for automated immobilization
Autor:
Donald Wlodkowic, Anna Matuszek, Khashayar Khoshmanesh, Kazuo Takeda, Jin Akagi, Yuu Fujimura
Publikováno v:
Sensors and Actuators B: Chemical. 189:2-10
Flow cytometry is one of the core technologies for single cell analysis and sorting based on fluorescent markers and functional probes. Nevertheless, popular adoption and proliferation of this technology is still limited by high costs, need for dedic
Autor:
Donald Wlodkowic, Jonathan M. Cooper, Christopher J. Hall, Khashayar Khoshmanesh, Kathryn E. Crosier, Jin Akagi, Philip S. Crosier
Publikováno v:
Sensors and Actuators B: Chemical. 189:11-20
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in molecular medicine and drug discovery. Nevertheless, automated in situ analysis of zebrafish embryos is still in early development. Currently available technologies do n
Autor:
Johnny Yeh, Jin Akagi, Zoran Salcic, Donald Wlodkowic, Feng Zhu, Kevin I-Kai Wang, Christopher J. Hall, Kathryn E. Crosier, Philip S. Crosier
Publikováno v:
Biosensors and Bioelectronics. 48:188-196
Lab-on-a-Chip (LOC) biomicrofluidic technologies are rapidly emerging bioanalytical tools that can miniaturize and revolutionize in situ research on embryos of small vertebrate model organisms such as zebrafish (Danio rerio) and clawed African frog (
Autor:
Donald Wlodkowic, Phil Crosier, Jonathan M. Cooper, Christopher J. Hall, Kathryn E. Crosier, Jin Akagi, Khashayar Khoshmanesh
Publikováno v:
Procedia Engineering. 47:84-87
Zebrafish (Danio rerio) has recently emerged as a powerful experimental model in drug discovery and environmental toxicology. Notwithstanding this, automated in-situ analysis of zebrafish embryos is still deeply in its infancy. Currently available te
Autor:
Donald Wlodkowic, Kourosh Kalantar-zadeh, Khashayar Khoshmanesh, Jin Akagi, Jonathan M. Cooper, David E. Williams, Sara Baratchi, Saeid Nahavandi
Publikováno v:
Analytical Chemistry. 83:3217-3221
Development of the dielectrophoretic (DEP) live cell trapping technology and its interfacing with the environmental scanning electron microscopy (ESEM) is described. DEP microelectrode arrays were fabricated on glass substrate using photolithography
Autor:
Joanna Skommer, Saeid Nahavandi, Khashayar Khoshmanesh, Jonathan M. Cooper, Kourosh Kalantar-zadeh, David E. Williams, Jin Akagi, Sara Baratchi, Donald Wlodkowic
Publikováno v:
Analytical Chemistry. 83:2133-2144
Quantification of programmed and accidental cell death provides useful end-points for the anticancer drug efficacy assessment. Cell death is, however, a stochastic process. Therefore, the opportunity to dynamically quantify individual cellular states