Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Jin‐Ran Chen"'
Autor:
Fumou Sun, Yan Cheng, Jun Ying, David Mery, Samer Al Hadidi, Visanu Wanchai, Eric R. Siegel, Hongwei Xu, Dongzheng Gai, Timothy Cody Ashby, Clyde Bailey, Jin-Ran Chen, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Siegfried Janz, Bart Barlogie, Frits Van Rhee, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract Multiple myeloma is preceded by monoclonal gammopathy of undetermined significance (MGUS). Serum markers are currently used to stratify MGUS patients into clinical risk groups. A molecular signature predicting MGUS progression has not been p
Externí odkaz:
https://doaj.org/article/06fafe2671dd496cac7b712408124b7b
Autor:
Jin-Ran Chen, Perry C. Caviness, Haijun Zhao, Beau Belcher, Umesh D. Wankhade, Kartik Shankar, Michael L Blackburn, Oxana P. Lazarenko
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2209-2222 (2022)
Studies from both humans and animal models indicated that maternal chronic poor-quality diet, especially a high fat diet (HFD), is significantly associated with reduced bone density and childhood fractures in offspring. When previously studied in a r
Externí odkaz:
https://doaj.org/article/1331f72c52864306a9d5a2a5e1c5464f
Autor:
Jin-Ran Chen, Oxana P. Lazarenko, Michael L. Blackburn, Jennifer F. Chen, Christopher E. Randolph, Jovanny Zabaleta, Katrin Schroder, Kim B. Pedersen, Martin J. J. Ronis
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Nox4 expression combined with reactive oxygen species signaling are key to osteoblast differentiation, proliferation and maturation in mice.
Externí odkaz:
https://doaj.org/article/2a8cb97bf2c942f39dfce424da5afa13
Autor:
Dongzheng Gai, Jin-Ran Chen, James P. Stewart, Intawat Nookaew, Hasem Habelhah, Cody Ashby, Fumou Sun, Yan Cheng, Can Li, Hongwei Xu, Bailu Peng, Tarun K. Garg, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Fangping Chen, Bart Barlogie, Frits van Rhee, Guido Tricot, John D. Shaughnessy Jr., Fenghuang Zhan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Osteolytic bone disease is a hallmark of multiple myeloma (MM). A significant fraction (~20%) of MM patients do not develop osteolytic lesions (OLs). The molecular basis for the absence of bone disease in MM is not understood. We combined PET-CT and
Externí odkaz:
https://doaj.org/article/e0033236077b4a64b805c9d221f71dcc
Autor:
Jin-Ran Chen, Haijun Zhao, Umesh D. Wankhade, Sree V. Chintapalli, Can Li, Dongzheng Gai, Kartik Shankar, Fenghuang Zhan, Oxana P. Lazarenko
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Chen et al. show that hippuric acid (HA), which is a diet-derived phenolic acid, inhibits bone resorption and increases bone mass in wild type mice, but not in G-protein coupled receptor (GPR109A) knockout mice. This study suggests that GPR109A media
Externí odkaz:
https://doaj.org/article/326219ecf5b84dbc89616cda50c648e4
Autor:
Dipendra Bhandari, Sangita Kachhap, Geet Madhukar, Kiran Kumar Adepu, Andriy Anishkin, Jin-Ran Chen, Sree V. Chintapalli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14778 (2022)
Previous research has indicated that various metabolites belonging to phenolic acids (PAs), produced by gut microflora through the breakdown of polyphenols, help in promoting bone development and protecting bone from degeneration. Results have also s
Externí odkaz:
https://doaj.org/article/a36367dc20624f919a9524f42180987e
Autor:
Jin‐Ran Chen, Oxana P Lazarenko, Eugenia Carvalho, Michael L Blackburn, Kartik Shankar, Umesh D Wankhade, Elisabet Børsheim
Publikováno v:
JBMR Plus, Vol 5, Iss 7, Pp n/a-n/a (2021)
ABSTRACT Mechanical stresses associated with physical activity (PA) have beneficial effects on increasing BMD and improving bone quality. However, a high‐fat diet (HFD) and obesity tend to have negative effects on bone, by increasing bone marrow ad
Externí odkaz:
https://doaj.org/article/adc9066c8e0a4677b7bffacff41951ac
Autor:
Jin‐Ran Chen, Oxana P Lazarenko, Haijun Zhao, Umesh D Wankhade, Kim Pedersen, James Watt, Martin J J Ronis
Publikováno v:
JBMR Plus, Vol 4, Iss 8, Pp n/a-n/a (2020)
ABSTRACT Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase‐ (Nox‐) dependent accumulation of ROS may be an approach t
Externí odkaz:
https://doaj.org/article/81889a3c52414d88a0850a0fb13fdb0e
Autor:
Jin‐Ran Chen, Umesh D Wankhade, Alexander W Alund, Michael L Blackburn, Kartik Shankar, Oxana P Lazarenko
Publikováno v:
JBMR Plus, Vol 3, Iss 9, Pp n/a-n/a (2019)
ABSTRACT Phenolic acids (PAs) are metabolites derived from polyphenolic compounds found in fruits and vegetables resulting from the actions of gut bacteria. Previously, we reported that the levels of seven individual PAs were found to be at least 10
Externí odkaz:
https://doaj.org/article/c2312d3bde714a80baa9957af880f7e7
Changes in Polyphenolics during Storage of Products Prepared with Freeze-Dried Wild Blueberry Powder
Autor:
Laura Lavefve, Cindi Brownmiller, Luke Howard, Donovon Reeves, Sean H. Adams, Jin-Ran Chen, Eva C. Diaz, Andy Mauromoustakos
Publikováno v:
Foods, Vol 9, Iss 4, p 466 (2020)
Wild blueberry (WBB) powder can be added to the formulation of foods to encourage consumption of health-promoting polyphenolics, but the stability of polyphenolics throughout storage is important. We determined the stability of polyphenolics in five
Externí odkaz:
https://doaj.org/article/48d1afe246c846828151062cc170a297