Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Jin‐Ming Yang"'
Autor:
Chrispus Ngule, Ruyi Shi, Xingcong Ren, Hongyan Jia, Felix Oyelami, Dong Li, Younhee Park, Jinhwan Kim, Hami Hemati, Yi Zhang, Xiaofang Xiong, Andrew Shinkle, Nathan L. Vanderford, Sara Bachert, Binhua P. Zhou, Jianlong Wang, Jianxun Song, Xia Liu, Jin-Ming Yang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Triple negative breast cancer (TNBC) is a particularly lethal breast cancer (BC) subtype driven by cancer stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), a me
Externí odkaz:
https://doaj.org/article/f74140f6f5a14ff3a6bfa413df989010
Autor:
Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important imp
Externí odkaz:
https://doaj.org/article/2af97a96aeb14b708a623902a676224f
Autor:
Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin‐Ming Yang, Na Ye, Yan Cheng
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple‐negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti‐cancer a
Externí odkaz:
https://doaj.org/article/a8feaa9fb69f4b188810e9844dd4c7be
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths have occurred despite drastic containment measures, and this number is still increasing. Cu
Externí odkaz:
https://doaj.org/article/959d5acc9bf54ab78d95d144671d5824
Autor:
Lixiang Gu, Xingcong Ren, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Zhiguo Li, Jin-Ming Yang
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2221 (2023)
Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the NACC1 gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes
Externí odkaz:
https://doaj.org/article/ff766ba15e3b492c8a13062889e987dc
Autor:
Anil Kumar, Yi Zhang, Jianxun Song, Liqing Wang, Jugal K Das, Yijie Ren, Hao-Yun Peng, Darby Balllard, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background T cell-mediated antitumor immunity has a vital role in cancer prevention and treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a significant contributor to immune evasion that weakens antitumor immunity. H
Externí odkaz:
https://doaj.org/article/396b522d9b124a29a5d862239a7a6732
Autor:
Jinhwan Kim, Yanfeng Li, Yan Cheng, Xingcong Ren, Yi Zhang, Cheng Ji, Hua Zhu, Yoshinori Takahashi, Xingdong Xiong, Lixiang Gu, Chrispus Ngule, Xiaofang Xiong, Jianxun Song, Xiaoqi Liu, Jin‐Ming Yang
Publikováno v:
Natural Sciences, Vol 2, Iss 3, Pp n/a-n/a (2022)
Abstract Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, and function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain to be ful
Externí odkaz:
https://doaj.org/article/83d314c05ccf4e4cbfdb70cc8544a1fd
Autor:
Chrispus M. Ngule, Hami Hemati, Xingcong Ren, Oluwafunminiyi Obaleye, Amos O. Akinyemi, Felix F. Oyelami, Xiaofang Xiong, Jianxun Song, Xia Liu, Jin-Ming Yang
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1223 (2023)
Triple-negative breast cancer (TNBC), characterized by a deficiency in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of breast cancer (BC). Nevertheless, the
Externí odkaz:
https://doaj.org/article/8574e984404e406ca8747aba157aa1db
Autor:
Darby J. Ballard, Hao-Yun Peng, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Eukaryotic Elongation Factor-2 Kinase (eEF2K) acts as a negative regulator of protein synthesis, translation, and cell growth. As a structurally unique member of the alpha-kinase family, eEF2K is essential to cell survival under stressful conditions,
Externí odkaz:
https://doaj.org/article/1b565e457eea44d3b1b45122df3841bc
Autor:
Liqing Wang, Anil Kumar, Jugal Kishore Das, Yijie Ren, Hao-Yun Peng, Darby Jane Ballard, Xiaofang Xiong, Jacob Rance Davis, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Publikováno v:
Viruses, Vol 14, Iss 8, p 1713 (2022)
Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the current stud
Externí odkaz:
https://doaj.org/article/43088b5d6bae4b5380ee1e5bf389e573