Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jin‐Feng Zhao"'
Autor:
Abigail Brewer, Jin-Feng Zhao, Rotimi Fasimoye, Natalia Shpiro, Thomas J. Macartney, Nicola T. Wood, Melanie Wightman, Dario R. Alessi, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110423- (2024)
Summary: TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer. TGF-β transcriptional responses are controlled b
Externí odkaz:
https://doaj.org/article/29d5d7de42d54273bca16ac8b4f72fb9
Autor:
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110432- (2024)
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplas
Externí odkaz:
https://doaj.org/article/06e99590560f4d84a989e659c12d87bb
Autor:
Francois Singh, Lea Wilhelm, Alan R. Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H. Ogmundsdottir, Ian G. Ganley
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTPINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy le
Externí odkaz:
https://doaj.org/article/5b57ed0a9adb48e88193d7ed8114fd86
Autor:
Tracy-Shi Zhang Fang, Yu Sun, Andrew C. Pearce, Simona Eleuteri, Mark Kemp, Christopher A. Luckhurst, Rachel Williams, Ross Mills, Sarah Almond, Laura Burzynski, Nóra M. Márkus, Christopher J. Lelliott, Natasha A. Karp, David J. Adams, Stephen P. Jackson, Jin-Feng Zhao, Ian G. Ganley, Paul W. Thompson, Gabriel Balmus, David K. Simon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may dr
Externí odkaz:
https://doaj.org/article/231adfbea4cd447195e9caff8d44823d
Autor:
Xiao-Die Cui, Jun-Kai Zhang, Ya-Wei Sun, Feng-Bin Yan, Jin-Feng Zhao, Dan-Dan He, Yu-Shan Pan, Li Yuan, Ya-Jun Zhai, Gong-Zheng Hu
Publikováno v:
Poultry Science, Vol 102, Iss 2, Pp 102346- (2023)
ABSTRACT: The emergence and rapid spread of multidrug resistant (MDR) Gram-negative bacteria have posed a serious threat to global health and security. Because of the time-consuming, high cost and high risk of developing new antibiotics, a significan
Externí odkaz:
https://doaj.org/article/f95f958214bb452493c8a285e68ce508
Publikováno v:
Guoji Yanke Zazhi, Vol 21, Iss 3, Pp 533-536 (2021)
AIM: To observe the changes of the development of the anterior segment in children after the treatment of laser photocoagulation(LP)for retinopathy of prematurity(ROP)by corneal topographic. METHODS: In this retrospective case study, 25 children(50 e
Externí odkaz:
https://doaj.org/article/aba08d41cf5e4229bbc3faf4c11f7c15
Autor:
Yingying Yang, Xiuhua Kuang, Rong-jia Han, Ya-jun Zhai, Dan-dan He, Jin-feng Zhao, Jian-hua Liu, Gong-zheng Hu
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT Streptococcus suis strain 1112S was isolated from a diseased pig in a feedlot from Henan, China, in 2019. The isolate harbored a linezolid resistance gene optrA. WGS data revealed that the optrA gene was associated with a single copy ETAf IS
Externí odkaz:
https://doaj.org/article/dad881c3aa7b4fdfb21b36a85b56e407
Publikováno v:
Cell Stress, Vol 4, Iss 5, Pp 99-113 (2020)
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process. Mitophagy is also involved in cell differentiation and maturation, potentially through
Externí odkaz:
https://doaj.org/article/1b8d21e6f9d545558d24530cf3ed4ed3
Autor:
Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K. Semple, Ian G. Ganley, Vicky E. MacRae
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1643 (2023)
Arterial calcification is an important characteristic of cardiovascular disease. It has key parallels with skeletal mineralization; however, the underlying cellular mechanisms responsible are not fully understood. Mitochondrial dynamics regulate both
Externí odkaz:
https://doaj.org/article/b99e971db0464787a2fe7e501279f7dc
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Studies revealed that the use of renin-angiotensin-aldosterone system antagonism is not associated with a statistically significant reduction in the risk of cardiovascular events in patients with chronic kidney disease (CKD) compared with that in the
Externí odkaz:
https://doaj.org/article/398f5a83ba7b4773b0f82c23e606d20f