Zobrazeno 1 - 10
of 3 678
pro vyhledávání: '"Jin, Tai"'
Autor:
Jujiao Kang, Yue-Ting Deng, Bang-Sheng Wu, Wei-Shi Liu, Ze-Yu Li, Shitong Xiang, Liu Yang, Jia You, Xiaohong Gong, Tianye Jia, Jin-Tai Yu, Wei Cheng, Jianfeng Feng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Alcohol consumption is a heritable behavior seriously endangers human health. However, genetic studies on alcohol consumption primarily focuses on common variants, while insights from rare coding variants are lacking. Here we leverage whole
Externí odkaz:
https://doaj.org/article/3832146c44b04cd79a8c03aea949af79
Autor:
Weikang Gong, Yan Fu, Bang-Sheng Wu, Jingnan Du, Liu Yang, Ya-Ru Zhang, Shi-Dong Chen, JuJiao Kang, Ying Mao, Qiang Dong, Lan Tan, Jianfeng Feng, Wei Cheng, Jin-Tai Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide association analysis of brain iron, measur
Externí odkaz:
https://doaj.org/article/7500d4213dad4a99afb9f86430992acc
Publikováno v:
Journal of Materials Research and Technology, Vol 31, Iss , Pp 772-786 (2024)
The increasing utilization of transparent ceramics in laser systems, particularly the magnesium aluminate spinel (MgAl2O4) transparent ceramic, has positioned it as the primary candidate for high energy laser system exit windows. Nevertheless, the in
Externí odkaz:
https://doaj.org/article/7df8ecc9adc54897b9ab75dcce981d4e
Autor:
Pei-Yang Gao, Ling-Zhi Ma, Xue-Jie Wang, Bang-Sheng Wu, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Nan Ou, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dement
Externí odkaz:
https://doaj.org/article/02f56ebedb084e8c864ec7a7115c0e9e
Autor:
Xiao-Yu He, Bang-Sheng Wu, Liu Yang, Yu Guo, Yue-Ting Deng, Ze-Yu Li, Chen-Jie Fei, Wei-Shi Liu, Yi-Jun Ge, Jujiao Kang, Jianfeng Feng, Wei Cheng, Qiang Dong, Jin-Tai Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Previous genetic studies of venous thromboembolism (VTE) have been largely limited to common variants, leaving the genetic determinants relatively incomplete. We performed an exome-wide association study of VTE among 14,723 cases and 334,315
Externí odkaz:
https://doaj.org/article/52e2d900e96d4b37bc1c83682135fd19
Autor:
Qiong-Yao Li, He-Ying Hu, Gao-Wen Zhang, Hao Hu, Ya-Nan Ou, Liang-Yu Huang, An-Yi Wang, Pei-Yang Gao, Li-Yun Ma, Lan Tan, Jin-Tai Yu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Cardiometabolic multimorbidity is associated with an increased risk of dementia, but the pathogenic mechanisms linking them remain largely undefined. We aimed to assess the associations of cardiometabolic multimorbidity with cereb
Externí odkaz:
https://doaj.org/article/e5bb7541e4be409198edac4ed563ddcf
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2024)
Abstract The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifaceted. A growing body of e
Externí odkaz:
https://doaj.org/article/61a79d8f9e3e4bfd9f37b4520bda4ba9
Autor:
Dan-Dan Zhang, Xiao-Yu He, Liu Yang, Bang-Sheng Wu, Yan Fu, Wei-Shi Liu, Yu Guo, Chen-Jie Fei, Ju-Jiao Kang, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011339 (2024)
BackgroundVaricose veins (VV) are one of the common human diseases, but the role of genetics in its development is not fully understood.MethodsWe conducted an exome-wide association study of VV using whole-exome sequencing data from the UK Biobank, a
Externí odkaz:
https://doaj.org/article/0162a43e32894509b11f0077609c919d
Autor:
Wei Liang Gan, Xi Ren, Vanessa Hui En Ng, Larry Ng, Yangyang Song, Vincent Tano, Jian Han, Omer An, Jinghe Xie, Bryan Y.L. Ng, Daryl Jin Tai Tay, Sze Jing Tang, Haoqing Shen, Shruti Khare, Kelvin Han Chung Chong, Dan Yock Young, Bin Wu, Ramanuj DasGupta, Leilei Chen
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114400- (2024)
Summary: ADAR1-mediated RNA editing establishes immune tolerance to endogenous double-stranded RNA (dsRNA) by preventing its sensing, primarily by MDA5. Although deleting Ifih1 (encoding MDA5) rescues embryonic lethality in ADAR1-deficient mice, they
Externí odkaz:
https://doaj.org/article/c57a92f54d0c4f0eb2c899bfc4bbaec0
Autor:
Yi-Xuan Qiang, Jia You, Xiao-Yu He, Yu Guo, Yue-Ting Deng, Pei-Yang Gao, Xin-Rui Wu, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Blood-based biomarkers for dementia are gaining attention due to their non-invasive nature and feasibility in regular healthcare settings. Here, we explored the associations between 249 metabolites with all-cause dementia (ACD), A
Externí odkaz:
https://doaj.org/article/96b1ad83ac0f45d99f88c5658a133a61