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Publikováno v:
Journal of Proteome Research; 20240101, Issue: Preprints
Akademický článek
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Autor:
Lasse Reimer, Hjalte Gram, Nanna Møller Jensen, Cristine Betzer, Li Yang, Lorrain Jin, Min Shi, Driss Boudeffa, Giuliana Fusco, Alfonso De Simone, Deniz Kirik, Hilal A Lashuel, Jing Zhang, Poul Henning Jensen
Publikováno v:
Reimer, L, Gram, H, Jensen, N M, Betzer, C, Yang, L, Jin, L, Shi, M, Boudeffa, D, Fusco, G, De Simone, A, Kirik, D, Lashuel, H A, Zhang, J & Jensen, P H 2022, ' Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation ', PNAS Nexus, vol. 1, no. 5, pgac259 . https://doi.org/10.1093/pnasnexus/pgac259
Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an equilibrium between disordered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb065111a4dd7bdda6003dc3667a1920
https://doi.org/10.1093/pnasnexus/pgac259
https://doi.org/10.1093/pnasnexus/pgac259
Autor:
Reimer L; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Gram H; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Jensen NM; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Betzer C; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Yang L; Department of Pathology, University of Washington School of Medicine, Seattle WA 98195, USA., Jin L; Department of Pathology, University of Washington School of Medicine, Seattle WA 98195, USA., Shi M; Department of Pathology, University of Washington School of Medicine, Seattle WA 98195, USA., Boudeffa D; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences Brain Mind Institute, Station 19, 1015 Lausanne, Switzerland., Fusco G; Centre for Misfolding Diseases,Department of Chemistry, University of Cambridge, CB2 1EW, UK., De Simone A; Department of Pharmacy, University of Naples, 80131, Naples, Italy., Kirik D; Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences Brain Mind Institute, Station 19, 1015 Lausanne, Switzerland., Zhang J; Department of Pathology, University of Washington School of Medicine, Seattle WA 98195, USA.; Department of Pathology, Zhejiang University School of Medicine and the First Affiliated Hospital, 310003 Hangzhou, China., Jensen PH; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Publikováno v:
PNAS nexus [PNAS Nexus] 2022 Nov 16; Vol. 1 (5), pp. pgac259. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).