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Lead optimization is a key step in drug discovery to produce potent and selective compounds. Historically, in silico screening and structure-based small molecule designing facilitated the processes. Although the recent application of deep learning to
Externí odkaz:
http://arxiv.org/abs/2108.05183
Autor:
Abrisqueta, Pau, González-Barca, Eva, Panizo, Carlos, Pérez, José María Arguiñano, Miall, Fiona, Bastos-Oreiro, Mariana, Triguero, Ana, Banerjee, Lalita, McMillan, Andrew, Seymour, Erlene, Hirata, Jamie, de Guzman, Jayson, Sharma, Sunil, Jin, Hyun Yong, Musick, Lisa, Diefenbach, Catherine *
Publikováno v:
In The Lancet Haematology February 2024 11(2):e136-e146
Autor:
Jin, Hyun Yong *, *, Tudor, Yanyan *, Choi, Kaylee *, Shao, Zhifei, Sparling, Brian A., McGivern, Joseph G., Symons, Antony **
Publikováno v:
In SLAS Discovery February 2020 25(2):215-222
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Autor:
Errington, Timothy, Denis, Alexandria, Perfito, Nicole, Tan, Fraser, Lomax, Joelle, Williams, Stephen, Tsui, Rachel, Gunn, William, Iorns, Elizabeth, Nosek, Brian, Acharya, Grishma, Adebamowo, Sally, Afshari, Amirali, Agius, Claire, Aird, Fraser, Allison, Anne, Amitai, Nurith, Anant, Madan, Anderson, Natalie, Ang, Lay-Hong, Antes, Travis, Araiza, Renee, Arora, Deepika, Aza-Blanc, Pedro, Bencsics, Craig, Berry, Deborah, Bhargava, Ajay, Biressi, Stefano, Blocher, Lawrence, Blum, David, Boedeker, Elizabeth, Bower, Lynette, Boyd, Leslie, Brinton, Lindsey, Brown, Claire, Bullenkamp, Jessica, Cai, Steve, Cajka, Tomas, Campos, Jessica, Carraway, Kermit, Carrell, Jacqueline, Carreno, Alberto, Cavadas, Miguel, Chang, Chih-Cheng, Chen, Biao, Chou, James, Chou, Wen-Ko, Chow, Kartoa, Chroscinski, Denise, Chu, Heidi, Cook, Matthew, Coss, Chris, Courville, Pascal, Cowley, Dale, Danet-Desnoyers, Gwenn, Dareng, Eileen, Delgadillo, I., de Morrée, Antoine, Denike, Trisha, Denson, Sarah, Dhami, Gurpreet, Ding, Jianhua, Donham, Cristine, Doroudchi, M., Eaton, Kate, Edwards, Meredith, Eriksson, Annika, Essex, Anthony, Evans, Bradley, Evans, James, Evans, Kristin, Fiehn, Oliver, Fields, Jennifer, Fiering, Steven, Fontaine, Clinton, Fung, Juan, Gallagher, Curtis, Grant, Jeff, Greenfield, Edward, Griner, Erin, Gormally, Michael, Gupta, Archana, Hao, Haiping, Harr, Kaitlyn, Haselton, Michael, Hatakeyama, Jason, Hause, Ronald, Haven, Babette, Helfrich, Stefan, Hewitt, Alex, Hilton, Heidi, Horrigan, Stephen, Hou, Jeff, Huang, Chun-Teng, Incardona, Francesca, Ismail, Nawfal, Jin, Hyun Yong, Jones, Martina, Joy-Gaba, Jonathan, Judson, Robert, Kandela, Irawati, Kerwin, John, Khan, Israr, Kim, Jeewon, Kim, Young, KOSAKA, ALAN, Krieger, Teresa, Kwok, Jennie, LaBarge, Samuel, Lacoste, Judith, Lam, Matthew, Lesnik, Jake, Lewis, L. Michelle, Li, Jia, Lim, Minyoung, Lopez-Serra, Lidia, Maalouf, Samar, Mack, Hildegard, Maddox, Ewa, Maherali, Nimet, Mantis, Christine, Marrello, Sara, Mathur, Maya, McCarthy, Michael, McDonald, Elysia, Meyers, Zachary, Mitrofan, Claudia-Gabriela, Newell, Crystal, Newman, Stephanie, Northan, Brian, Owen, Katherine, Pandya, Kumar, Pedro, Luisa, Pelech, Steven, Pelletier, Vincent, Permaul, Eva, Peterson, Maureen, Phelps, Mitch, Pike, Amanda, Pineda, Javier, Pirani, Ali, Poe, Sara, Poindexter, Kevin, Polyzos, Aris, Pudlo, Nicholas, Radomska, Hanna, Raouf, Samrrah, Ratcliffe, Darrell, Ray, Courtney, Repass, John, Richardson, Adam, Rusckowski, Mary, Russler-Germain, David, Sampey, Darryl, Schaner Tooley, Christine, Scott, David, Sebastiano, Vittorio, Sen, Supti, Sengupta, Ranjita, Settles, Michael, Shakya, Reena, Shan, Xiaochuan, Shan, Yongli, Sharma, Vidhu, Sheen, Mee, Showalter, Megan, Skinner, Laura, Smith, Tim, Snitkin, Evan, Soderberg, Courtney, Statt, Sarah, Steelman, Brandon, Sutter, Catherine, Talbot, C., Tang, Beibei, Tolentino, Todd, Trinh, Angela, Unnikrishnan, Ashwin, Heuvel, Jack, Vandervorst, Kacey, Vasilevsky, Nicole, Veal, Mathew, Vowles, Chriss, Wang, Hongyan, Wang, Zhiyong, Weston, Claire, Willis, Brandon, Wilson, Ashley, Wood, Joshua, Woodard, Ben, Xin, Hong, Yan, Xuefei, Yang, Huajun, Yang, Wanwan, Young, Lisa, Yucel, Nora, Yue, Lambert, Zagnitko, Olga, Zervantonakis, Ioannis, zhou, faren
We are conducting a study to investigate the replicability of cancer biology studies. Selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010-2012 are being replicated by the Science Exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c74f1d104ad524f4a4f12bf7654a8c11
Autor:
Jin, Hyun Yong1,2, Oda, Hiroyo1, Chen, Pengda3, Yang, Chao3, Zhou, Xiaojuan3, Kang, Seung Goo4, Valentine, Elizabeth5, Kefauver, Jennifer1,2, Liao, Lujian6, Zhang, Yaoyang7, Gonzalez-Martin, Alicia1, Shepherd, Jovan1, Morgan, Gareth J.8, Mondala, Tony S.9, Head, Steven R.9, Kim, Pyeung-Hyeun10, Xiao, Nengming3, Fu, Guo3, Liu, Wen-Hsien3, Han, Jiahuai3
Publikováno v:
PLoS Genetics. 2/27/2017, Vol. 13 Issue 2, p1-38. 38p.
Akademický článek
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