Výsledky vyhledávání - "Jimmy Stofferis"

Monitoring and Control of Genotoxic Impurity Acetamide in the Synthesis of Zaurategrast Sulfate

Autor: Magali Palacio, Célal Ates, Arnaud Schule, Jean-Pierre Delatinne, Jimmy Stofferis, Bruno Martin, Steven Lloyd

Publikováno v: Organic Process Research & Development. 14:1008-1014

In this article we describe the strategy adopted to minimize the risk of acetamide presence in zaurategrast sulfate drug candidate. A risk of acetamide formation (a potential genotoxic impurity) was identified in the API formation step of the process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c41a885cdebabbc8a89f527418b3f2fb
https://doi.org/10.1021/op900330e

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From Clone Selection to 80L Bioreactor Production: Better, Faster, Leaner

Autor: Matthew Hinchliffe, Laetitia Malphettes, Guillaume Le Reverend, Marie-Françoise Clincke, Jimmy Stofferis, Frédéric Delouvroy

Publikováno v: BMC Proceedings

Materials and methods AmbrTM 48 and 80L stirred tank bioreactor were run for 14 days in a fed-batch mode in a chemically defined medium. A CHO cell line expressing a recombinant monoclonal antibody (MAb) was used. Feed was added daily from day 3 onwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a028027a2bb4bb4015206dcc53cc289
https://doi.org/10.1186/1753-6561-9-s9-p34

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[4+2] Cycloaddition of 1-aminodienes and 2-substituted vinylphosphonates: application to asymmetric synthesis of 3-amino-5-phosphono-1-cyclohexene derivatives

Autor: Raphaël Robiette, Jacqueline Marchand-Brynaert, Nathalie Defacqz, Jimmy Stofferis

Publikováno v: Tetrahedron. 59:4167-4175

N-Butadienylsuccinimide (1), iso-propyl N-butadienyl-(S)-pyroglutamate (5) and N-butadienyl-(R)-4-phenyloxazolidin-2-one (6) reacted with vinylphosphonates, vicinally-substituted (2) by electronwithdrawing groups (CO2Me, CN, COMe), to furnish [4+2] c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::478592ab3c22418eb3a6fe0ed4a5d830
https://doi.org/10.1016/s0040-4020(03)00580-5

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Feeding strategy optimization in interaction with target seeding density of a fed-batch process for monoclonal antibody production

Autor: Grégory Mathy, Guillaume Le Reverend, Nicola Bonsu-Dartnall, Laura Gimenez, Bassem Ben Yahia, Laetitia Malphettes, Jimmy Stofferis, Marie-Françoise Clincke, Boris Fessler

Publikováno v: BMC Proceedings

Background Current trend towards Quality by Design (QbD) leads the process development exercise towards systematic experimentation, rational development, process understanding, characterization and control. In this study, an example of the applicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5ecd88b3cab204fb59b5c926532fe2
https://doi.org/10.1186/1753-6561-7-s6-p78

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Development and fine-tuning of a scale down model for process characterization studies of a monoclonal antibody upstream production process

Autor: Laetitia Malphettes, Mareike Harmsen, Jimmy Stofferis

Publikováno v: BMC Proceedings
BMC Proceedings, Vol 5, Iss Suppl 8, p P70 (2011)

Background It has always been an objective of process development and more recently it has also become a regulatory expectation to build robustness into and demonstrate proper control of a manufacturing process, thus ensuring that the biological prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b47f54b4f46370505702da3a396876a
http://europepmc.org/articles/PMC3284957

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