Bacterial Postgenomics: the Promise and Peril of Systems Biology ▿

Autor: Barry S. Goldman, Jimmy S. Jakobsen, Mitchell Singer, Roy D. Welch, Anthony G. Garza, Garret Suen

Publikováno v: Journal of Bacteriology. 188:7999-8004

A postulate of systems biology is that, within the sum total of its genomic data, a network map of all functional interactions exists for each organism ([5][1]), and this “interaction map” can be assembled from that data agglomeration through the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76207b1509dc827f8e2340f9c98c36df
https://doi.org/10.1128/jb.01195-06

Host factor I, Hfq, binds to Escherichia coli ompA mRNA in a growth rate-dependent fashion and regulates its stability

Autor: Manuela Baccarini, Oresta Vytvytska, Gina Balcunaite, Jimmy S. Jakobsen, Jens S. Andersen, Alexander von Gabain

Publikováno v: Vytvytska, O, Jakobsen, J S, Balcunaite, G, Andersen, J S, Baccarini, M & von Gabain, A 1998, ' Host factor I, Hfq, binds to Escherichia coli ompA mRNA in a growth rate-dependent fashion and regulates its stability. ', Proceedings of the National Academy of Science of the United States of America, vol. 95, no. 24, pp. 14118-23 . https://doi.org/10.1073/pnas.95.24.14118

The stability of the ompA mRNA depends on the bacterial growth rate. The 5′ untranslated region is the stability determinant of this transcript and the target of the endoribonuclease, RNase E, the key player of mRNA degradation. An RNA-binding prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a47040c7568134eedf3541acb0316a
https://doi.org/10.1073/pnas.95.24.14118