Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jimmy Fourtounis"'
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Autor:
Jimmy Fourtounis, John Martino, Rino Stocco, Prasamit Baruah, Nicole Duffy, David Gallo, Sarah Fournier, JingJing Li, Li Li, Elia Aguado, Adam Petrone, Anne Roulston, Yael Mamane, Stephen Morris, Janek Szychowski, Robert Papp, Mike Zinda, C. Gary Marshall
Publikováno v:
Cancer Research. 82:5650-5650
Cyclin E1, the protein product of the CCNE1 gene, complexes with CDK2 and is a key regulator of the G1-S transition in cycling cells. CCNE1 amplification has been associated with increased replication stress and genomic instability associated with tu
Autor:
Daigen Xu, Maria Antonietta Davoli, Steven Xanthoudakis, Jimmy Fourtounis, John Tam, George S. Robertson, Gordon Y.K. Ng, Donald W. Nicholson
Publikováno v:
Neuroscience. 115:125-136
In the present study, we evaluated the time-course of caspase-3 activation, and the evolution of cell death following focal cerebral ischemia produced by transient middle cerebral artery occlusion in rats. Ischemia-induced active caspase-3 immunoreac
Autor:
I-Ming Wang, Yves Boie, Michael A. Crackower, Jimmy Fourtounis, Aimee L. Jackson, Marie-Claude Mathieu, Alex G. Therien, David Claveau, Mette A Peters, Tenneille Loo
Publikováno v:
Respiratory Research
Respiratory Research, Vol 13, Iss 1, p 92 (2012)
Respiratory Research, Vol 13, Iss 1, p 92 (2012)
Background Oxidative Stress contributes to the pathogenesis of many diseases. The NRF2/KEAP1 axis is a key transcriptional regulator of the anti-oxidant response in cells. Nrf2 knockout mice have implicated this pathway in regulating inflammatory air
Publikováno v:
Analytical biochemistry. 411(1)
We describe a novel method of characterizing protein-RNA interactions using a fluorescence-based multiwell capillary electrophoresis platform based on microfluidic technology. As a proof of concept, we studied the binding of human immunodeficiency vi
Autor:
George S. Robertson, Gordon Y.K. Ng, Yubo Ren, Cindy Jones, Maria Antonietta Davoli, Yanxia Zhu, Jimmy Fourtounis, Daigen Xu
Publikováno v:
Journal of neuroscience methods. 115(1)
In the brain, DNA fragmentation is associated with apoptotic cell death following ischemic/excitotoxic damage. Fragmented DNA can be detected in situ by labeling the 3'OH termini of the internucleosomal generated fragments with deoxynucleotides, thro