Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jimmy D. Neill"'
Autor:
Morton B. Brown, David T. Mauger, Jimmy D. Neill, Fred J. Karsch, Judith Van Cleeff, Geoffrey E. Dahl, Neil P. Evans, Vasantha Padmanabhan
Publikováno v:
Endocrinology. 144:1380-1392
Our previous studies in ovariectomized ewes have provided direct evidence that FSH secretion is comprised of basal and episodic modes. In those studies, each GnRH pulse coincided with an FSH pulse, but additional FSH pulses were noted. To determine w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7bb77c28729b878bf257a29aefd693
https://doi.org/10.1210/en.2002-220973
https://doi.org/10.1210/en.2002-220973
Autor:
Jimmy D. Neill
Publikováno v:
Endocrinology. 143:737-743
Four different GnRHs and one GnRH receptor are reported to be expressed in various mammals, whereas 13 GnRHs and numerous GnRH receptors have been identified in various nonmammalian vertebrates. The nucleotide sequencing of the human genome provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c860a8196f81396c05d3a749f5208da4
https://doi.org/10.1210/endo.143.3.8705
https://doi.org/10.1210/endo.143.3.8705
Autor:
Jimmy D. Neill
Publikováno v:
Archives of Physiology and Biochemistry. 110:129-136
Mammalian gonadotropin-releasing hormone (GnRH I) is a hypothalamic decapeptide that governs gonadotropin secretion through interaction with its seven transmembrane (7TM), G protein-coupled receptor (GPCR) expressed by anterior pituitary cells. A sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0350df6814870b14d4c770e129025f38
https://doi.org/10.1076/apab.110.1.129.900
https://doi.org/10.1076/apab.110.1.129.900
Publikováno v:
Biochemical and Biophysical Research Communications. 282:1012-1018
Mammalian gonadotropin-releasing hormone (GnRH I) is a hypothalamic decapeptide that stimulates gonadotropic hormone secretion upon interaction with its membrane receptors (type I) on pituitary cells, thereby governing reproductive processes. A secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bf0e5aad24a6db18850a7a72eafffb
https://doi.org/10.1006/bbrc.2001.4678
https://doi.org/10.1006/bbrc.2001.4678
Publikováno v:
Endocrinology. 140:2562-2569
The level of LH secretion is determined by both alterations in gonadotrope responsiveness and alterations in GnRH secretion. The molecular mechanisms underlying gonadotrope responsiveness are unknown, but may include G protein-coupled receptor kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0faeced237db543fa05421ad01a6ae
https://doi.org/10.1210/endo.140.6.6688
https://doi.org/10.1210/endo.140.6.6688
Publikováno v:
Life Sciences. 64:2215-2223
The mechanisms of GnRH-induced desensitization of LH secretion are poorly understood. Protein kinase C (PKC) and protein kinase A (PKA) desensitize some receptors of the 7-membrane type, and the GnRH receptor has consensus phosphorylation sites for P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a47f4391cd6760790e6b0f305cb0a3
https://doi.org/10.1016/s0024-3205(99)00173-3
https://doi.org/10.1016/s0024-3205(99)00173-3
Publikováno v:
Molecular and Cellular Endocrinology. 127:143-154
The molecular cloning and nucleotide sequencing of the gonadotropin-releasing hormone (GnRH) receptor represented an enhanced step in the experimental effort to understand this key molecule in the reproductive process at a cell and molecular level. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c20b2565209e3c017ed1ff15333330d4
https://doi.org/10.1016/s0303-7207(96)04003-8
https://doi.org/10.1016/s0303-7207(96)04003-8
Publikováno v:
Molecular and Cellular Endocrinology. 106:145-149
Inhibition of the growth of hormone related human tumor cells in vitro by GnRH agonists and antagonists suggests a direct effect on cell growth and proliferation, and this effect may be achieved through its receptors present in tumor cells. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2798e88845bb92c1d0dca7543fe5077
https://doi.org/10.1016/0303-7207(94)90196-1
https://doi.org/10.1016/0303-7207(94)90196-1
Publikováno v:
Neuroendocrinology. 57:422-431
Secretogranin II (SgII) is an acidic 86-kD protein which is synthesized by most neuroendocrine cells but occurs in greatest abundance in the anterior pituitary gland where it is localized primarily in gonadotrophs. In the present studies, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ddad8eabc198428917df56f898540f
https://doi.org/10.1159/000126388
https://doi.org/10.1159/000126388