Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jimit Lakhani"'
Autor:
Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray
Publikováno v:
eLife, Vol 11 (2022)
The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number of malignancies, and this complex represents a prom
Externí odkaz:
https://doaj.org/article/885c81e0f1964e4e986cf2271d9a8b62
Autor:
Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, Anthony C. Varca, Jonathan Bruyr, Samira Ibrahim, Tasneem Jivanjee, Joshua D. Bromley, Sarah K. Nyquist, Aaron Richardson, Hong Yue, Yang Wang, Natalia Calonghi, Alessandra Stefan, Kerstin Spirohn, Didier Vertommen, Maria F. Baietti, Irma Lemmens, Hyuk-Soo Seo, Mikhail G. Dozmorov, Luc Willems, Jan Tavernier, Kalyan Das, Eleonora Leucci, Alejandro Hochkoeppler, Zhen-Yu Jim Sun, Michael A. Calderwood, Tong Hao, Alex K. Shalek, David E. Hill, Andras Boeszoermenyi, Haribabu Arthanari, Sara J. Buhrlage, Sirano Dhe-Paganon, Javier González-Maeso, Franck Dequiedt, Jean-Claude Twizere, Marc Vidal
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity and high toxicity due to targeting multiple enzyme paralogs, which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8635e9e2aa438eb8f00e273e12bf49c9
https://doi.org/10.1101/2022.12.07.519454
https://doi.org/10.1101/2022.12.07.519454
Autor:
Wenchao Lu, Mengyang Fan, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7924e28c4bfb69b5d5fe572049b49a2
https://doi.org/10.7554/elife.78810.sa2
https://doi.org/10.7554/elife.78810.sa2
Autor:
Ertan Eryilmaz, Wilson Guzman, Dheeraj S. Tomar, Parker Johnson, Stephanie Hsiao, Lisa Quinn, Nancy Chan, Jimit Lakhani, Brendan Whalen, Rosa Quiroz, Kurt Jenkins, Oleg Yerov, Will Scott, Justin Greene, Zhen Liu, Megan McLaughlin, Sallyann Vu, Chelsea Turcotte, Hanumantha R. Madala, Jacob Taylor, Caitlin O'Toole, Magali Pederzoli-Ribeil, Haley Duprey, Natalia Malkova, Damiano Fantini, David Crowe, Sean Yang, Kyle Smith, Joseph Card, Janice Lee, Kerri Smith, Benjamin Nicholson, Jijun Dong, Jennifer O'Neil, Carl U. Bialucha
Publikováno v:
Cancer Research. 83:572-572
Although PD-1/PD-L1 therapies have shown significant activity across a range of tumor types, only a subset of patients (10-30%) achieve durable responses. With the goal of improving response and application to PD-1/PD-L1 therapies, we have leveraged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bcd3835b32d6e84f664b0207a5ede39
https://doi.org/10.1158/1538-7445.am2023-572
https://doi.org/10.1158/1538-7445.am2023-572
Autor:
Wenchao Lu, Mengyang Fan, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray
Publikováno v:
eLife. 11
The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number of malignancies, and this complex represents a prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11a2569dbdc990bd7da7df07df10bfb
https://pubmed.ncbi.nlm.nih.gov/36300789
https://pubmed.ncbi.nlm.nih.gov/36300789
Autor:
Jimit Lakhani, Hyuk-Soo Seo, Olesja Popow, Kevin M. Haigis, Christian Johnson, Ezekiel A. Geffken, Elizabeth M. Terrell, Kimberly Hagel, Deborah K. Morrison, Kijun Song, Sirano Dhe-Paganon, Carla Mattos
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd400389ae58745465ac293191d88251
https://doi.org/10.1096/fasebj.2021.35.s1.01476
https://doi.org/10.1096/fasebj.2021.35.s1.01476
Autor:
Christian W. Johnson, Hyuk-Soo Seo, Elizabeth M. Terrell, Moon-Hee Yang, Fenneke KleinJan, Teklab Gebregiworgis, Genevieve M.C. Gasmi-Seabrook, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Puspalata Bashyal, Olesja Popow, Joao A. Paulo, Andrea Liu, Carla Mattos, Christopher B. Marshall, Mitsuhiko Ikura, Deborah K. Morrison, Sirano Dhe-Paganon, Kevin M. Haigis
Publikováno v:
Mol Cell
A unifying feature of the RAS superfamily is a conserved GTPase cycle by which these proteins transition between active and inactive states. We demonstrate that autophosphorylation of some GTPases is an intrinsic regulatory mechanism that reduces nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7484f8740b33d67a4e92ca475419fc4
https://doi.org/10.1016/j.molcel.2022.02.011
https://doi.org/10.1016/j.molcel.2022.02.011