Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Jimin, Gao"'
Autor:
Wen Lei, Ai Zhao, Hui Liu, Chunmei Yang, Cheng Wei, Shanshan Guo, Zhilu Chen, Qunyi Guo, Linjie Li, Mingzhe Zhao, Gongqiang Wu, Guifang Ouyang, Ming Liu, Jinyi Zhang, Jimin Gao, Wenbin Qian
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Although CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), disease relapse with tumor antigen-positive remains a challenge. Cytokine/chemokine-expres
Externí odkaz:
https://doaj.org/article/cfcb19c9c9bd4e5d8b7f347d75b7e0b5
Autor:
Hui Lian, Jinhong Jiang, Yao Wang, Xiaoxiao Yu, Rong Zheng, Jing Long, Mengjie Zhou, Shirong Zhou, Cheng Wei, Ai Zhao, Jimin Gao
Publikováno v:
Cancer Medicine, Vol 11, Iss 15, Pp 2978-2989 (2022)
Abstract Background CARs are engineered receptors comprising an immunoglobulin single‐chain variable fragment (scFv) that identifies and binds to the target antigen, a transmembrane domain, and an intracellular T‐cell signaling domain. CD19 is a
Externí odkaz:
https://doaj.org/article/250d5cc3fa0343b49b864c021a5ce17c
Autor:
Yanhong Sun, Zhifang Chen, Yi Xu, Yuefang Zhang, Zhilei Ge, Chenglie Lin, Yi Zhou, Fangfei Zhao, Meiling Yan, Xinyi Liu, Ying Zhu, Jimin Gao, Hongyi Li, Lihua Wang, Jun Hu, Zilong Qiu, Chunhai Fan
Publikováno v:
Engineering, Vol 12, Iss , Pp 83-89 (2022)
Rett syndrome is a progressive neurodevelopmental disorder that lacks effective treatments. Although deep-brain stimulation can alleviate some symptoms in Rett model mice, this interventional manipulation requires deliberate surgical operations. Here
Externí odkaz:
https://doaj.org/article/8433cac0ca514cfaacf8838c8828d5f8
Autor:
Fanfan Li, Shuping Zhao, Cheng Wei, Yaodi Hu, Tianlong Xu, Xueyi Xin, Tingwei Zhu, Liting Shang, Shanwen Ke, Jiang Zhou, Xiaojun Xu, Yue Gao, Ai Zhao, Jimin Gao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundChimeric antigen receptor T (CAR-T) cell therapy has made significant advances for hematological malignancies but encounters obstacles in the treatment of solid tumors mainly due to tumor immunosuppressive microenvironment.MethodsImmunohist
Externí odkaz:
https://doaj.org/article/1cdf43d9d1d5439e97f2f2e531bb59dd
Autor:
Dongqing Wang, Heying Chen, Li Lei, Jun Chen, Jimin Gao, Jiahe Liu, Qianyin Li, Yajun Xie, Yi Hu, Yilu Ni
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Abstract Effective skin wound healing is a complex process involving anti‐inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage‐mediated anti‐inflammation and fibroblast‐assisted matrix r
Externí odkaz:
https://doaj.org/article/94171198fb354330b2c92e455c96274e
Autor:
Cheng Wei, Kangfu Xia, Yucheng Xie, Sishi Ye, Yanghui Ding, Zairu Liu, Rong Zheng, Jing Long, Qinchuan Wei, Yumei Li, Dongxia Yang, Xiaojun Xu, Ai Zhao, Jimin Gao
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T cell therapy has been verified to be safe based on clinical trials. However, due to the poor pers
Externí odkaz:
https://doaj.org/article/e86d187e66504f2b8ee583b8d6e46fb2
Autor:
Hua Ni, Min Li, Qiaoqiao Wang, Jing Wang, Xumiao Liu, Feng Zheng, Dan Hu, Xu Yu, Yifang Han, Qi Zhang, Tingting Zhou, Yiwen Wang, Chunhui Wang, Jimin Gao, Zhu-Qing Shao, Xiuzhen Pan
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 927-940 (2020)
Streptococcus suis serotype 2 (S. suis 2) is an important swine pathogen and also an emerging zoonotic agent. HtpsA has been reported as an immunogenic cell surface protein on the bacterium. In the present study, we constructed an isogenic mutant str
Externí odkaz:
https://doaj.org/article/8be8e939be1c4fef915909926f4951a0
Autor:
Deming Duan, Keke Wang, Cheng Wei, Dudu Feng, Yonghua Liu, Qingyan He, Xing Xu, Chunling Wang, Shuping Zhao, Leili Lv, Jing Long, Danni Lin, Ai Zhao, Bingmu Fang, Jinhong Jiang, Shixing Tang, Jimin Gao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chimeric antigen receptor (CAR) technology has revolutionized cancer treatment, particularly in malignant hematological tumors. Currently, the BCMA-targeted second-generation CAR-T cells have showed impressive efficacy in the treatment of refractory/
Externí odkaz:
https://doaj.org/article/70eda8b85c524601a7041c54ada03d0c
Autor:
Juan Liu, Cen Zhang, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza, Dajing Xia, Jimin Gao, Eileen White, Bruce G. Haffty, Wenwei Hu, Zhaohui Feng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus in
Externí odkaz:
https://doaj.org/article/21615c60190c416990f49adb86754ecf
Autor:
Yufei Wang, Wanbo Tai, Jie Yang, Guangyu Zhao, Shihui Sun, Chien-Te K. Tseng, Shibo Jiang, Yusen Zhou, Lanying Du, Jimin Gao
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 7, Pp 1615-1624 (2017)
Middle East respiratory syndrome (MERS) continues to raise worldwide concerns due to its pandemic potential. Increased MERS cases and no licensed MERS vaccines highlight the need to develop safe and effective vaccines against MERS. We have previously
Externí odkaz:
https://doaj.org/article/ad6ea64c9a09403e93dabafb13b9402e