CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells

Autor: Kotidis, Pavlos, Donini, Roberto, Arnsdorf, Johnny, Hansen, Anders Holmgaard, Voldborg, Bjørn Gunnar Rude, Chiang, Austin W.T., Haslam, Stuart M., Betenbaugh, Michael, Jimenez del Val, Ioscani, Lewis, Nathan E., Krambeck, Frederick, Kontoravdi, Cleo

Publikováno v: In Metabolic Engineering March 2023 76:87-96

Moving towards an era of hybrid modelling: advantages and challenges of coupling mechanistic and data-driven models for upstream pharmaceutical bioprocesses

Autor: Tsopanoglou, Apostolos, Jiménez del Val, Ioscani

Publikováno v: In Current Opinion in Chemical Engineering June 2021 32

Integration of models and experimentation to optimise the production of potential biotherapeutics

Autor: Royle, Kate E., Jimenez del Val, Ioscani, Kontoravdi, Cleo

Publikováno v: In Drug Discovery Today December 2013 18(23-24):1250-1255

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Autor: Fan, Yuzhou, Jimenez Del Val, Ioscani, Müller, Christian, Lund, Anne Mathilde, Wagtberg Sen, Jette, Rasmussen, Søren Kofoed, Kontoravdi, Cleo, Baycin-Hizal, Deniz, Betenbaugh, Michael J., Weilguny, Dietmar, Andersen, Mikael Rørdam

Publikováno v: Fan, Y, Jimenez Del Val, I, Müller, C, Lund, A M, Wagtberg Sen, J, Rasmussen, S K, Kontoravdi, C, Baycin-Hizal, D, Betenbaugh, M J, Weilguny, D & Andersen, M R 2015, ' A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture ', Biotechnology and Bioengineering
, vol. 112, no. 10, pp. 2172-2184 . https://doi.org/10.1002/bit.25620

In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1202::d467cb57f4d1cf178ef09997939ec197
https://orbit.dtu.dk/en/publications/032ff7ec-9b40-4a61-8f15-f7c40fa6a14e

Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures

Autor: Jimenez Del Val, Ioscani

The pharmaceutical industry is going through a rather turbulent period. Many blockbuster drugs have fallen off patent over the past two years and many more are expected to do so in the near future. In response, pharmaceutical companies have continued

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad6f163e9a3fcde1046e6dbba4c30cf