Emergence of co-expression in gene regulatory networks.

Autor: Wencheng Yin, Luis Mendoza, Jimena Monzon-Sandoval, Araxi O Urrutia, Humberto Gutierrez

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0247671 (2021)

Transcriptomes are known to organize themselves into gene co-expression clusters or modules where groups of genes display distinct patterns of coordinated or synchronous expression across independent biological samples. The functional significance of

Externí odkaz: https://doaj.org/article/81b373a25010427490e2b59ff67fdf84

Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson’s Disease

Autor: Lucia F. Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng Li

Publikováno v: Cells, Vol 12, Iss 24, p 2860 (2023)

Advances in stem cell technologies open up new avenues for modelling development and diseases. The success of these pursuits, however, relies on the use of cells most relevant to those targeted by the disease of interest, for example, midbrain dopami

Externí odkaz: https://doaj.org/article/4514585e6d484764b01803e2bda5c805

Protein Amino Acid Composition: A Genomic Signature of Encephalization in Mammals

Autor: Araxi O. Urrutia, Atahualpa Castillo, Humberto Gutierrez, Jimena Monzon

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27261 (2011)
Gutierrez, H, Castillo Morales, A, Monzon, J & Urrutia, A O 2011, ' Protein amino acid composition: a genomic signature of encephalization in mammals ', PLoS ONE, vol. 6, no. 11, e27261 . https://doi.org/10.1371/journal.pone.0027261

Large brains relative to body size represent an evolutionarily costly adaptation as they are metabolically expensive and demand substantial amounts of time to reach structural and functional maturity thereby exacerbating offspring mortality while del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8249447fb75e78959510cb8cfed9ac5
http://europepmc.org/articles/PMC3223171

TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

Autor: Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B. Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S. James, Emma Mead, John B. Davis, Sally A. Cowley

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-27 (2020)

Abstract Background TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. I

Externí odkaz: https://doaj.org/article/7003790f6cc94c199bdb2b9d9a1caf4d

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

Autor: Katharina E. Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M. Hoolachan, Suzan M. Hammond, Frank Abendroth, Olivier G. de Jong, Gareth Hazell, Nina Ahlskog, Matthew J.A. Wood, Caleb Webber, Melissa Bowerman

Publikováno v: JCI Insight, Vol 6, Iss 13 (2021)

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify potentially novel treatments to alleviate muscl

Externí odkaz: https://doaj.org/article/843557b3540e4f2b89480716bcc32369