Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jimena Monzón-Sandoval"'
Publikováno v:
Cells, Vol 12, Iss 24, p 2860 (2023)
Advances in stem cell technologies open up new avenues for modelling development and diseases. The success of these pursuits, however, relies on the use of cells most relevant to those targeted by the disease of interest, for example, midbrain dopami
Externí odkaz:
https://doaj.org/article/4514585e6d484764b01803e2bda5c805
Autor:
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E. Handel, Liting Wei, John Davis, Sally A. Cowley, M. Zameel Cader, Caleb Webber
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/71d2d166952149deaacfd3fb1e483bae
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8122 (2023)
Inhibitory GABAergic interneurons originate in the embryonic medial ganglionic eminence (MGE) and control network activity in the neocortex. Dysfunction of these cells is believed to lead to runaway excitation underlying seizure-based neurological di
Externí odkaz:
https://doaj.org/article/4f3f7c8134914b9284a515126e6a3953
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
A major challenge in medical genomics is to understand why individuals with the same disorder have different clinical symptoms and why those who carry the same mutation may be affected by different disorders. In every complex disorder, identifying th
Externí odkaz:
https://doaj.org/article/fe45dd2eff1b4c729adc4ccc206a0c70
Autor:
Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B. Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S. James, Emma Mead, John B. Davis, Sally A. Cowley
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-27 (2020)
Abstract Background TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. I
Externí odkaz:
https://doaj.org/article/7003790f6cc94c199bdb2b9d9a1caf4d
Autor:
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The substantia nigra is important in neurological disease, particularly movement disorders. Here the authors provide a single cell transcriptomic atlas for the human substantia nigra.
Externí odkaz:
https://doaj.org/article/b479fe2c43c740f2a5200c552a91eb31
Autor:
Katharina E. Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M. Hoolachan, Suzan M. Hammond, Frank Abendroth, Olivier G. de Jong, Gareth Hazell, Nina Ahlskog, Matthew J.A. Wood, Caleb Webber, Melissa Bowerman
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify potentially novel treatments to alleviate muscl
Externí odkaz:
https://doaj.org/article/843557b3540e4f2b89480716bcc32369
Autor:
Wencheng Yin, Navei Cerda-Hernández, Atahualpa Castillo-Morales, Mayra L. Ruiz-Tejada-Segura, Jimena Monzón-Sandoval, Perla Moreno-Castilla, Rodrigo Pérez-Ortega, Federico Bermudez-Rattoni, Araxi O. Urrutia, Humberto Gutiérrez
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline a
Externí odkaz:
https://doaj.org/article/6047779981f64602af4c3edb273a0106
Autor:
Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Alexandra A. de Sousa, Araxi O. Urrutia, Humberto Gutierrez
Publikováno v:
Open Biology, Vol 6, Iss 10 (2016)
Increased brain size is thought to have played an important role in the evolution of mammals and is a highly variable trait across lineages. Variations in brain size are closely linked to corresponding variations in the size of the neocortex, a disti
Externí odkaz:
https://doaj.org/article/e25073ac78e840bdbea7d187e7930569
Autor:
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E. Handel, Liting Wei, John Davis, Sally A. Cowley, M. Zameel Cader, Caleb Webber
Alzheimer's disease (AD) is the most common form of dementia, and risk-influencing genetics implicates microglia and neuroimmunity in the pathogenesis of AD. Induced pluripotent stem cell (iPSC)-derived microglia (iPSC-microglia) are increasingly use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f854a05c4d2bd33600dbf30d9c35f258
https://ora.ox.ac.uk/objects/uuid:52c960f8-01b6-40da-a180-17acf81b6fcd
https://ora.ox.ac.uk/objects/uuid:52c960f8-01b6-40da-a180-17acf81b6fcd