Výsledky vyhledávání - "Jimena A Ballestero"

Akademický článek

Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.

Autor: Alejandro O Sodero, Valeria C Castagna, Setiembre D Elorza, Sara M Gonzalez-Rodulfo, María A Paulazo, Jimena A Ballestero, Mauricio G Martin, María Eugenia Gomez-Casati

Publikováno v: PLoS Biology, Vol 21, Iss 8, p e3002257 (2023)

Cholesterol contributes to neuronal membrane integrity, supports membrane protein clustering and function, and facilitates proper signal transduction. Extensive evidence has shown that cholesterol imbalances in the central nervous system occur in agi

Externí odkaz: https://doaj.org/article/c767ae71c5a0473f80ca9fbe3649de3b

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Akademický článek

A point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection.

Autor: Julian Taranda, Stéphane F Maison, Jimena A Ballestero, Eleonora Katz, Jessica Savino, Douglas E Vetter, Jim Boulter, M Charles Liberman, Paul A Fuchs, A Belén Elgoyhen

Publikováno v: PLoS Biology, Vol 7, Iss 1, p e18 (2009)

The transduction of sound in the auditory periphery, the cochlea, is inhibited by efferent cholinergic neurons projecting from the brainstem and synapsing directly on mechanosensory hair cells. One fundamental question in auditory neuroscience is wha

Externí odkaz: https://doaj.org/article/fe6e8caadb304db3972a5af73403bdc9

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Sensitivity to Envelope Interaural Time Differences: Modeling Auditory Modulation Filtering

Autor: Andrew Brughera, Jimena A. Ballestero, David McAlpine

Publikováno v: J Assoc Res Otolaryngol

For amplitude-modulated sound, the envelope interaural time difference (ITD(ENV)) is a potential cue for sound-source location. ITD(ENV) is encoded in the lateral superior olive (LSO) of the auditory brainstem, by excitatory-inhibitory (EI) neurons r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d586e91a9b633a77194397cf0d09876d
https://doi.org/10.1007/s10162-021-00816-0

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Sensitivity to Envelope Interaural Time Difference: Models of Diverse LSO Neurons

Autor: Jimena A. Ballestero, Andrew Brughera, David McAlpine

A potential auditory spatial cue, the envelope interaural time difference (ITDENV) is encoded in the lateral superior olive (LSO) of the brainstem. Here, we explore computationally modeled LSO neurons, in reflecting behavioral sensitivity to ITDENV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c4d24cc79c84c8be49feb2d411b223b
https://doi.org/10.1101/2020.09.08.288282

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A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity

Autor: Mariano N. Di Guilmi, Ana Belén Elgoyhen, Carolina Wedemeyer, Paul A. Fuchs, Jimena A. Ballestero, Stéphane F. Maison, Marcelo J. Moglie, Julián Taranda, Eleonora Katz, Lucas G. Vattino, M. Charles Liberman

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final targets of several feedback loo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3c3bef893ed97a63d16d0d446293f5
https://doi.org/10.1523/jneurosci.2528-17.2018

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Activation of Presynaptic GABAB(1a,2)Receptors Inhibits Synaptic Transmission at Mammalian Inhibitory Cholinergic Olivocochlear–Hair Cell Synapses

Autor: Eleonora Katz, Ana Vanesa Torbidoni, Ana Belén Elgoyhen, Jimena A. Ballestero, Carolina Wedemeyer, Javier Zorrilla de San Martin, Paul A. Fuchs, María Eugenia Gómez-Casati, Bernhard Bettler

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The synapse between olivocochlear (OC) neurons and cochlear mechanosensory hair cells is cholinergic, fast, and inhibitory. The inhibitory sign of this cholinergic synapse is accounted for by the activation of Ca 2+ -permeable postsynaptic α9α10 ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b301dd083c345b112dade419a9196de9
https://doi.org/10.1523/jneurosci.2554-13.2013

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Constitutive Expression of the α10 Nicotinic Acetylcholine Receptor Subunit Fails to Maintain Cholinergic Responses in Inner Hair Cells After the Onset of Hearing

Autor: Julián Taranda, Douglas E. Vetter, Flavio S. J. de Souza, Marcela Lipovsek, Hakim Hiel, Carolina Wedemeyer, Eleonora Katz, Jimena A. Ballestero, Paul A. Fuchs, M. Eugenia Gómez-Casati, A. Belén Elgoyhen

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Efferent inhibition of cochlear hair cells is mediated by α9α10 nicotinic cholinergic receptors (nAChRs) functionally coupled to calcium-activated, small conductance (SK2) potassium channels. Before the onset of hearing, efferent fibers transiently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29cc9b37dd1c0ec923c7245a1db0e89
https://doi.org/10.1007/s10162-009-0173-z

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Subthreshold resonance properties contribute to the efficient coding of auditory spatial cues

Autor: Michiel W. H. Remme, Roberta Donato, Simon Foster, Jason Mikiel-Hunter, John Rinzel, Jimena A. Ballestero, David McAlpine

Publikováno v: Proceedings of the National Academy of Sciences. 111

Neurons in the medial superior olive (MSO) and lateral superior olive (LSO) of the auditory brainstem code for sound-source location in the horizontal plane, extracting interaural time differences (ITDs) from the stimulus fine structure and interaura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ba50dee5d19ff6a18d053220304450
https://doi.org/10.1073/pnas.1316216111

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Reducing Current Spread by Use of a Novel Pulse Shape for Electrical Stimulation of the Auditory Nerve

Autor: David McAlpine, Matthieu Recugnat, Katie E. Smith, Jimena A. Ballestero, Daniel Gnansia, Daniel J. Jagger, Jonathan Laudanski

Publikováno v: Trends in Hearing
Trends in Hearing, Vol 19 (2015)

Improving the electrode-neuron interface to reduce current spread between individual electrodes has been identified as one of the main objectives in the search for future improvements in cochlear-implant performance. Here, we address this problem by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db7788e0f426657200cc710799897d
https://doi.org/10.1177/2331216515619763

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Short term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells

Autor: Ana Belén Elgoyhen, Eleonora Katz, Juan Diego Goutman, Jimena A. Ballestero, Javier Zorrilla de San Martin, Paul A. Fuchs

Publikováno v: J. Neurosci. 2011;31(41):14763-14774
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

In the mammalian inner ear, the gain control of auditory inputs is exerted by medial olivocochlear (MOC) neurons that innervate cochlear outer hair cells (OHCs). OHCs mechanically amplify the incoming sound waves by virtue of their electromotile prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ba0907eae818b1cb5749b6c9461809
https://europepmc.org/articles/PMC3224807/

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