Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jimcy Platholi"'
Autor:
Jimcy Platholi, Roberta Marongiu, Laibaik Park, Fangmin Yu, Garrett Sommer, Rena Weinberger, William Tower, Teresa A. Milner, Michael J. Glass
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Dementia is often characterized by age-dependent cerebrovascular pathology, neuroinflammation, and cognitive deficits with notable sex differences in risk, disease onset, progression and severity. Women bear a disproportionate burden of dementia, and
Externí odkaz:
https://doaj.org/article/08b853b7a9284138b3773081b9b062ca
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Multiple presynaptic and postsynaptic targets have been identified for the reversible neurophysiological effects of general anesthetics on synaptic transmission and neuronal excitability. However, the synaptic mechanisms involved in persistent depres
Externí odkaz:
https://doaj.org/article/4b40152ce4de4ef3a3b8a1bbfa65145d
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102978 (2014)
General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction. However, the subcellul
Externí odkaz:
https://doaj.org/article/35a28ef178f2499885c2c539dc5c303e
Autor:
Jimcy Platholi, Hugh C. Hemmings
Publikováno v:
Current neuropharmacology. 20(1)
General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission principally by modulating the function of glutamatergic or GABAergic synapses, respectively, with relative anesthetic agent-specific mechanisms. Synaptic signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd8d03c1d7bc8e15994661d7de81e53
https://pubmed.ncbi.nlm.nih.gov/34344292
https://pubmed.ncbi.nlm.nih.gov/34344292
Autor:
Jimcy Platholi, Hugh C. Hemmings
Publikováno v:
Adv Pharmacol
A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165
A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165
Protein phosphatase-1 (PP-1), a highly conserved multifunctional serine/threonine phosphatase, is enriched in dendritic spines where it plays a major role in modulating excitatory synaptic activity. In addition to established functions in spine matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9972d2f22c4df153195b69d18e6e04a9
https://pubmed.ncbi.nlm.nih.gov/33706930
https://pubmed.ncbi.nlm.nih.gov/33706930
Publikováno v:
Journal of Comparative Neurology. 525:3563-3578
Voltage-gated Na+ channels (Nav ) modulate neuronal excitability, but the roles of the various Nav subtypes in specific neuronal functions such as synaptic transmission are unclear. We investigated expression of the three major brain Nav subtypes (Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa3770bad5cf917ddbf0ae6660f77ca
https://doi.org/10.1002/cne.24291
https://doi.org/10.1002/cne.24291
Autor:
Yael Abreu-Villaça, Jane Adams, Richard Agans, Syed F. Ali, Michael Aschner, William J. Barbaresi, David C. Bellinger, Julie Bickel, Lilly Bogičević, Jolene E. Borchelt, Thomas M. Burbacher, Johanna Calderon, Carl E. Cerniglia, Louis W. Chang, John J. Chelonis, Elvis Cuevas, Nancy L. Day, John M. DeSesso, Alessandra A. Dos Santos, Diana Dow-Edwards, Sherry A. Ferguson, Jeffrey W. Fisher, Jan M. Friedman, Julia M. Gohlke, Mari Golub, Devon L. Graham, Kimberly S. Grant, Robert M. Greene, Qiang Gu, Michelle Guignet, Joseph Hanig, Thomas Hartung, Keli M. Hawthorne, Zhen He, Mary E. Huddleston, Saber Hussain, Syed Z. Imam, Shinya Ito, Patricia A. Janulewicz, Karl F. Jensen, David A. Jett, Thomas B. Knudsen, Andrew D. Kraft, Kannan Krishnan, Prateek Lala, Susan M. Lantz, Stephen M. Lasley, Francis S. Lee, Tom Leibson, Pamela J. Lein, Edward D. Levin, Grace Liejun Guo, John C. Lipscomb, Fang Liu, Feiyuan Liu, Shuliang Liu, Jocelyn M. Lutes, Susan L. Makris, Ashley J. Malin, Alexandra Mendlein, Jerrold S. Meyer, Mellessa M. Miller, Philip G. Morgan, Geeta Negi, Irena Nulman, Jeanene K. Olin, Tucker A. Patterson, Merle G. Paule, Michele M. Pisano, Jimcy Platholi, Gale A. Richardson, Courtney Roper, Hector Rosas-Hernandez, Helen J.K. Sable, Katerine S. Saili, Richard L. Salisbury, Sumit Sarkar, Margaret M. Sedensky, Larry P. Sheets, Talya Shulman, William Slikker, Lena Smirnova, Andrew Snyder, Christina Sobin, Gregg D. Stanwood, Suangsuda Supasai, John C. Talpos, Robert L. Tanguay, Charles Timchalk, Anneloes van Baar, Marjolein Verhoeven, Jennifer L. Walters, Cheng Wang, Amy L. Williams, Robert O. Wright, Xiaoxia Yang, Qi Yin, Xuan Zhang, Todd J. Zurlinden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d28727f44bc8c40d20d32e556a450e
https://doi.org/10.1016/b978-0-12-809405-1.00060-2
https://doi.org/10.1016/b978-0-12-809405-1.00060-2
Publikováno v:
Journal of Biological Chemistry. 289:23893-23900
Protein phosphatase 1I (PP-1I) is a major endogenous form of protein phosphatase 1 (PP-1) that consists of the core catalytic subunit PP-1c and the regulatory subunit inhibitor 2 (I-2). Phosphorylation of the Thr-72 residue of I-2 is required for act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cb4080de07b43b29dd90d1f4cd1651
https://doi.org/10.1074/jbc.m114.557744
https://doi.org/10.1074/jbc.m114.557744
Autor:
Paul M. Heerdt, Jimcy Platholi, H.Y. Lim Tung, S. Andrew Bullock, Ada Gjyrezi, Hugh C. Hemmings
Publikováno v:
Biochemical and Biophysical Research Communications. 358:140-144
Neurabin is a brain-specific actin and protein phosphatase-1 (PP-1) binding protein that inhibits the purified catalytic subunit of protein phosphatase-1 (PP-1(C)). However, endogenous PP-1 exists primarily as multimeric complexes of PP-1(C) bound to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2a2872623e675cf43f4b918c91c850
https://doi.org/10.1016/j.bbrc.2007.04.076
https://doi.org/10.1016/j.bbrc.2007.04.076