Výsledky vyhledávání - "Jim W. Barnett"

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells

Autor: Francisco Xavier Talamas, Brian Wong, Simon W. Lee, Terrence Z. Cai, Pam S. Olson, Kyung Song, Mohammad Hekmat-Nejad, Anthony M. Manning, Ronald J. Hill, Jim W. Barnett, Rebecca Suttmann, Kelly D. Thompson, Sue Jin

Publikováno v: Molecular Immunology. 46:1458-1466

IRAK-1 and IRAK-4 are protein kinases that mediate signaling by Toll/IL1/Plant R (TIR) domain-containing receptors including the IL-1, IL-18, and Toll-like receptors (TLRs). Although well studied in mouse systems, the mechanism by which they function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d430aac48fb332f3957fca412838e1
https://doi.org/10.1016/j.molimm.2008.12.012

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Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations

Autor: Jim W. Barnett, Andreas Kuglstatter, Kyung Song, Armando G. Villaseñor, Linghao Niu, Simon W. Lee, David E. Shaw, Stan Tsing, Michelle F. Browner

Publikováno v: The Journal of Immunology. 178:2641-2645

IL-1R-associated kinase (IRAK)4 plays a central role in innate and adaptive immunity, and is a crucial component in IL-1/TLR signaling. We have determined the crystal structures of the apo and ligand-bound forms of human IRAK4 kinase domain. These st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fffe047704e2379c0394b880ca08635
https://doi.org/10.4049/jimmunol.178.5.2641

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Differential Allosteric Regulation of Prostaglandin H Synthase 1 and 2 by Arachidonic Acid

Autor: Amy Y. Mak, Chakkodabylu S. Ramesha, Jim W. Barnett, David C. Swinney

Publikováno v: Journal of Biological Chemistry. 272:12393-12398

Prostaglandins are synthesized by prostaglandin H synthase (PGHS) 1 and 2. PGHS2 is regulated through inducible expression. We report here the regulation of PGHS1 activity by substrate-dependent cooperative activation. The cooperativity is characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e96f27cfdce24918e25adfecab23f6
https://doi.org/10.1074/jbc.272.19.12393

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Fed-batch culture of insect cells: a method to increase the yield of recombinant human nerve growth factor (rhNGF) in the baculovirus expression system

Autor: Sandra Williams, Binh T. Nguyen, Kurt Jarnagin, Hardy Chan, Jim W. Barnett

Publikováno v: Journal of Biotechnology. 31:205-217

A fed-batch method was developed which increased the density of insect cells (Spodoptera frugiperda, Sf-9 cells) in suspension culture and the feeding of nutrients improved the yield of a recombinant protein produced by a baculovirus expression syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca82febd46428f3dc041f25ef8210d1d
https://doi.org/10.1016/0168-1656(93)90161-f

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Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Autor: Jim W. Barnett, Andreas Kuglstatter, J.M. Bradshaw, David E. Shaw, Simon W. Lee, Stan Tsing, Michelle F. Browner, April Wong, Armando G. Villaseñor, Y. Lou

Bruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X-ray crystal structures of BTK kinase domain in complex with six in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54040d9bae455a4ac65a9b88b0faba3a
https://europepmc.org/articles/PMC3048427/

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X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors

Autor: Manjiri Ghate, David E. Shaw, Armando G. Villaseñor, Stan Tsing, Jim W. Barnett, Michelle F. Browner, Andreas Kuglstatter

Publikováno v: Bioorganicmedicinal chemistry letters. 20(17)

JNK2 and p38alpha are closely related mitogen-activated protein kinases that regulate various cellular activities and are considered drug targets for inflammatory diseases. We have determined the X-ray crystal structure of the clinical phase II p38al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bd6d9e4ee50dcbf5d8c5eda9853389
https://pubmed.ncbi.nlm.nih.gov/20655210

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Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes

Autor: Hoangdung Ho, Armando G. Villaseñor, Sandra M. Wang, Andreas Kuglstatter, Jim W. Barnett, Michelle F. Browner, David E. Shaw, Rama K. Kondru, Eva Papp

Publikováno v: Chemical biologydrug design. 73(4)

Spleen tyrosine kinase is considered an attractive drug target for the treatment of allergic and antibody mediated autoimmune diseases. We have determined the co-crystal structures of spleen tyrosine kinase complexed with three known inhibitors: YM19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ef91778a2d9f55bf86a3b363b07a63
https://pubmed.ncbi.nlm.nih.gov/19220318

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Physicochemical Characterization of Recombinant Human Nerve Growth Factor Produced in Insect Cells with a Baculovirus Vector

Autor: Jodi Fausnaugh, Natalie Saldou, Hardy Chan, Daryl K. Eggers, Eric Osen, Ken Straub, Jack Lile, Frank H. Collins, Joan Chow, Leo Gu, Raymond R. Townsend, Kurt Jarnagin, Hi-Shi Chaing, Binh T. Nguyen, Jim W. Barnett, Lisa Erdos

Publikováno v: Journal of Neurochemistry. 57:1052-1061

Recombinant human nerve growth factor (rhNGF) secreted by insect cells was purified by ion-exchange and reversed-phase chromatography to near homogeneity. The N-terminus of the secreted molecule was analogous to that of mouse salivary gland NGF. In i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce9988524eb6a1dd21ac2d07e6e4093
https://doi.org/10.1111/j.1471-4159.1991.tb08256.x

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The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity

Autor: Andreas Kuglstatter, Armando G. Villaseñor, Jim W. Barnett, David Walter, Stan Tsing, Michelle F. Browner, Sandra M. Wang, David E. Shaw

Publikováno v: Journal of molecular biology. 383(4)

c-Jun N-terminal kinase (JNK) 2 is a member of the mitogen-activated protein (MAP) kinase group of signaling proteins. MAP kinases share a common sequence insertion called “MAP kinase insert”, which, for ERK2, has been shown to interact with regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a696739ea76f35a7a16e66991ab113
https://pubmed.ncbi.nlm.nih.gov/18801372

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