Zobrazeno 1 - 10
of 377
pro vyhledávání: '"Jim Sang"'
Autor:
David A. Proia, Richard C. Bates, Chaohua Zhang, Manuel Sequeira, Donald L. Smith, Jim Sang, Suqin He, Jaime Acquaviva
Because of their pleiotropic effects on critical oncoproteins, inhibitors of HSP90 represent a promising new class of therapeutic agents for the treatment of human cancer. However, pharmacologic inactivation of HSP90 subsequently triggers a heat shoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d518ffa53eb998697fddfd6c89cf8ef9
https://doi.org/10.1158/1541-7786.c.6540027.v1
https://doi.org/10.1158/1541-7786.c.6540027.v1
Autor:
David A. Proia, Richard C. Bates, Jim Sang, Suqin He, Manuel Sequeira, Chaohua Zhang, John-Paul Jimenez, Donald L. Smith, Jaime Acquaviva
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f030065ea7250ad6040a432416bcf1
https://doi.org/10.1158/1535-7163.22500582
https://doi.org/10.1158/1535-7163.22500582
Autor:
Weiwen Ying, Dinesh Chimmanamada, Richard C. Bates, Sami Osman, Noriaki Tatsuta, Takayo Inoue, Igor Astsaturov, Vladimir Khazak, Chaohua Zhang, Suqin He, Jaime Acquaviva, Manuel Sequeira, Luisa Shin Ogawa, Jim Sang, John-Paul Jimenez, Junyi Zhang, Donald L. Smith, David A. Proia
Plasma stability assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16576181af7e8366e9045c5c59596d21
https://doi.org/10.1158/1535-7163.22506805.v1
https://doi.org/10.1158/1535-7163.22506805.v1
Autor:
Weiwen Ying, Dinesh Chimmanamada, Richard C. Bates, Sami Osman, Noriaki Tatsuta, Takayo Inoue, Igor Astsaturov, Vladimir Khazak, Chaohua Zhang, Suqin He, Jaime Acquaviva, Manuel Sequeira, Luisa Shin Ogawa, Jim Sang, John-Paul Jimenez, Junyi Zhang, Donald L. Smith, David A. Proia
The clinical benefits of chemotherapy are commonly offset by insufficient drug exposures, narrow safety margins, and/or systemic toxicities. Over recent decades, a number of conjugate-based targeting approaches designed to overcome these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f9bc9986cb6f4f2bd1cefcc5ef01b1
https://doi.org/10.1158/1535-7163.c.6538495.v1
https://doi.org/10.1158/1535-7163.c.6538495.v1
Autor:
Weiwen Ying, Dinesh Chimmanamada, Richard C. Bates, Sami Osman, Noriaki Tatsuta, Takayo Inoue, Igor Astsaturov, Vladimir Khazak, Chaohua Zhang, Suqin He, Jaime Acquaviva, Manuel Sequeira, Luisa Shin Ogawa, Jim Sang, John-Paul Jimenez, Junyi Zhang, Donald L. Smith, David A. Proia
HSP90 binding promotes the intracellular retention of HSP90 inhibitor-BODIPY probes in tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014519ba899563e4f1919adfd2ea71c7
https://doi.org/10.1158/1535-7163.22506823.v1
https://doi.org/10.1158/1535-7163.22506823.v1
Autor:
David A. Proia, Yumiko Wada, Chaohua Zhang, Manuel Sequeira, Suqin He, Julie C. Friedland, Jim Sang, Donald L. Smith, Jaime Acquaviva
PDF file - 79K, Fold-changes in protein expression following ganetespib treatment in KRAS mutant NSCLC lines using reverse phase protein array analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a627d062b65c31571c1686c452ff0cf4
https://doi.org/10.1158/1535-7163.22498731
https://doi.org/10.1158/1535-7163.22498731
Autor:
David A. Proia, Yumiko Wada, Chaohua Zhang, Manuel Sequeira, Suqin He, Julie C. Friedland, Jim Sang, Donald L. Smith, Jaime Acquaviva
Mutant KRAS is a feature of more than 25% of non–small cell lung cancers (NSCLC) and represents one of the most prevalent oncogenic drivers in this disease. NSCLC tumors with oncogenic KRAS respond poorly to current therapies, necessitating the pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f6ba1650f4e61b1ecf9be31054e08
https://doi.org/10.1158/1535-7163.c.6535959.v1
https://doi.org/10.1158/1535-7163.c.6535959.v1
Autor:
Weiwen Ying, Dinesh Chimmanamada, Richard C. Bates, Sami Osman, Noriaki Tatsuta, Takayo Inoue, Igor Astsaturov, Vladimir Khazak, Chaohua Zhang, Suqin He, Jaime Acquaviva, Manuel Sequeira, Luisa Shin Ogawa, Jim Sang, John-Paul Jimenez, Junyi Zhang, Donald L. Smith, David A. Proia
Cross-species plasma stability of STA-12-8666 as a function of time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22d113ac9042df40dbd281707cfed92
https://doi.org/10.1158/1535-7163.22506802.v1
https://doi.org/10.1158/1535-7163.22506802.v1
Autor:
David A. Proia, Richard C. Bates, Jim Sang, Suqin He, Manuel Sequeira, Chaohua Zhang, John-Paul Jimenez, Donald L. Smith, Jaime Acquaviva
PDF file - 378K, Inhibition of BRAF V600E enhances the activity of the MEK inhibitor AZD6244 in vemurafenib-resistant melanoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39035f7f2139bd807c59446cdc08919
https://doi.org/10.1158/1535-7163.22500585.v1
https://doi.org/10.1158/1535-7163.22500585.v1
Autor:
Weiwen Ying, Dinesh Chimmanamada, Richard C. Bates, Sami Osman, Noriaki Tatsuta, Takayo Inoue, Igor Astsaturov, Vladimir Khazak, Chaohua Zhang, Suqin He, Jaime Acquaviva, Manuel Sequeira, Luisa Shin Ogawa, Jim Sang, John-Paul Jimenez, Junyi Zhang, Donald L. Smith, David A. Proia
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56261c0c5a501d4768495f05342f25f7
https://doi.org/10.1158/1535-7163.22506808.v1
https://doi.org/10.1158/1535-7163.22506808.v1