Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jim S. Sexton"'
Autor:
Caroline O'Hare, Hilary Mackay, John A. Hartley, Toni Brown, Jerome Kluza, Binh Nguyen, Boris Savic, Jim S. Sexton, Daniel Hochhauser, W. David Wilson, Moses Lee, Minal Kotecha
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2093-2102
The synthesis and DNA binding characteristics of a polyamide-intercalator conjugate, designed to inhibit NF-Y binding to the ICB-2 site of the topoisomerase IIalpha promoter and up-regulate the expression of the enzyme in confluent cells, are reporte
Autor:
Jim S. Sexton, Keith Mulder, Peter B. Uthe, Zarmeen T. Taherbhai, Toni Brown, Moses Lee, Justin B. Jones
Publikováno v:
Synthetic Communications. 38:33-44
Four N‐formamido‐containing mono‐and diheterocyclic pyrrole‐ and imidazole‐2‐containing acids 1–4 were synthesized as intermediates for the preparation of polyamide molecules. The N‐formamido‐moiety forces the compounds to bind stro
Autor:
Jerome Kluza, John A. Hartley, Caroline O'Hare, Karen L. Buchmueller, Jim S. Sexton, Peter B. Uthe, Daniel Hochhauser, Lloyd V. Flores, Andrew M. Staples, W. David Wilson, Cameron M. Howard, Hilary Mackay, Moses Lee
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(11)
The synthesis and DNA-binding properties of a novel naphthalimide-polyamide hairpin (3) designed to target the inverted CCAAT box 2 (ICB2) site on the topoisomerase IIalpha (topoIIalpha) promoter are described. The polyamide component of 3 was derive
Autor:
Zarmeen T. Taherbhai, Justin B. Jones, Michelle Stewart, Caroline O'Hare, David Wilson, Toni Brown, Binh Nguyen, Hilary Mackay, Moses Lee, Jerome Kluza, Lindsay Stallings, John A. Hartley, Mark Turlington, Karen L. Buchmueller, Jim S. Sexton, Arden Sutterfield
Publikováno v:
Bioorganicmedicinal chemistry. 15(1)
Five polyamide derivatives with rationally modified C-terminus moieties were synthesized and their DNA binding specificity and affinity determined. A convergent approach was employed to synthesize polyamides containing an alkylaminopiperazine (4 and
Autor:
Lloyd V. Flores, Andrew M. Staples, Hilary Mackay, Cameron M. Howard, Peter B. Uthe, Jim S. Sexton, Karen L. Buchmueller, W. David Wilson, Caroline O'Hare, Jerome Kluza, Daniel Hochhauser, John A. Hartley, Moses Lee
Publikováno v:
ChemBioChem; Nov2006, Vol. 7 Issue 11, p1722-1729, 8p