Zobrazeno 1 - 10
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pro vyhledávání: '"Jim Proctor"'
Autor:
Jim Proctor
Contemporary scholarship has given rise to several modes of understanding biophysical and human nature, each entangled with related notions of science and religion. Envisioning Nature, Science, and Religion represents the culmination of three years o
Autor:
Godelieve Lammens, Bianca Feyen, Petra Vinken, Jim Proctor, Mark D. Johnson, Rao N.V.S. Mamidi, Sandra De Jonghe
Publikováno v:
Chemico-Biological Interactions. 277:85-90
During preclinical development of canagliflozin, an SGLT2 inhibitor, treatment-related pheochromocytomas, renal tubular tumors (RTT), and testicular Leydig cell tumors were reported in the 2-year rat toxicology study. In a previous 6-month rat mechan
Autor:
Petra Vinken, Sandra De Jonghe, Jim Proctor, Mark D. Johnson, Bianca Feyen, Dirk Mariën, Helena Geys, Inneke Wynant, Rao N.V.S. Mamidi
Publikováno v:
Chemico-Biological Interactions. 224:1-12
The carcinogenicity potential of canagliflozin, an inhibitor of SGLT2, was evaluated in a 2-year rat study (10, 30, and 100 mg/kg). Rats showed an increase in pheochromocytomas, renal tubular tumors, and testicular Leydig cell tumors. Systemic exposu
Publikováno v:
Toxicologic Pathology. 43:48-56
Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, has been developed for the treatment of adults with type 2 diabetes mellitus (T2DM). During the phase 3 program, treatment-related pheochromocytomas, renal tubular tumors, and testic
Autor:
Bianca Feyen, Sandra De Jonghe, Calvert Louden, Petra Vinken, Stewart Bryant, Godelieve Lammens, Rao N.V.S. Mamidi, Sandra Snook, Mark D. Johnson, Esther Moesen, Michael F. Kelley, Jim Proctor, Kirk Ways, Jing Ying Ma
Publikováno v:
Chemico-Biological Interactions. 221:109-118
Canagliflozin is an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Studies were conducted to investigate the mechanism responsible for renal tubular tumors and pheochromocytomas observed at the high dose in a 2-year carcinogenici
Autor:
Peter Taggart, Jean McCarthy, S. Jim Proctor, Erin Saleh, L. Mark Kao, Angelique M. Leone, Lynn Varacallo, Michael K. McMillian, Kelley Michael F, Monica Singer
Publikováno v:
Advances in Bioscience and Biotechnology. :216-229
Idiosyncratic hepatotoxicity accounts for many drug failures in the clinic and is a leading cause for black-boxed and withdrawn drugs. This toxicity has proven difficult to predict preclinically, but correlates with oxidative stress/reactive metaboli
Autor:
Jim Proctor
Lake Lure, North Carolina, is known as the �Gem of the Carolinas.� Twenty-five years after Dr. Lucius Morse and his brothers Hiram and Asahil purchased Chimney Rock in 1902, their dream of creating Lake Lure and the town of Lake Lure was realized
Autor:
Angelique Leone, S. Jim Proctor, Geert R. Verheyen, Mark D. Johnson, Michael McMillian, L. Mark Kao, Leigh-Anne Piechta, Michael F. Kelley, Alex Nie, J. Brandon Parker, Peter G. Lord, Sharmilee Sawant
Publikováno v:
Toxicology and applied pharmacology. 275(3)
Previously we reported a gene expression signature in rat liver for detecting a specific type of oxidative stress (OS) related to reactive metabolites (RM). High doses of the drugs disulfiram, ethinyl estradiol and nimesulide were used with another d
Autor:
Jim Proctor, Michael E. Zimmerman
Publikováno v:
Economic Geography. 72:456
Autor:
Jim Proctor
Publikováno v:
Education + Training. 13:407-422
Revised regulations from the CNAA offer scope for flexibility in awarding honours degrees. Mr Proctor, former Senior Assistant Registrar of the CNAA and now Assistant Director with responsibility for course development at North East London Polytechni