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Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators

Autor: Jim Ottelé, Bin Liu, Meagan A Beatty, Kai Liu, Sijbren Otto, Charalampos G. Pappas

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(24), 13569-13573. WILEY-V C H VERLAG GMBH

Nature segregates fundamental tasks such as information storage/transmission and catalysis between two different compound classes (e.g. polynucleotides for replication and folded polyamides for catalysis). This division of labor is likely a product o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5316ced095ed525cfe5da37eb672c339
https://hdl.handle.net/11370/e831e945-b8eb-4378-8efd-934b1418522d

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Chemical Fueling Enables Molecular Complexification of Self‐Replicators**

Autor: Jim Ottelé, Ankush Sood, Elio Mattia, Andreas S. Hussain, Sijbren Otto, Omer Markovitch, Kai Liu, Shuo Yang, Gaël Schaeffer

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(20), 11344-11349. WILEY-V C H VERLAG GMBH

Unravelling how the complexity of living systems can (have) emerge(d) from simple chemical reactions is one of the grand challenges in contemporary science. Evolving systems of self‐replicating molecules may hold the key to this question. Here we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4dddf2fbd61ae87e412eeba259e3769
https://doi.org/10.1002/anie.202016196

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Stochastic Emergence of Two Distinct Self-Replicators from a Dynamic Combinatorial Library

Autor: Gaël Schaeffer, Marcel J. Eleveld, Jim Ottelé, Peter C. Kroon, Pim W. J. M. Frederix, Shuo Yang, Sijbren Otto

Publikováno v: Journal of the American Chemical Society, 144(14), 6291-6297. AMER CHEMICAL SOC

Unraveling how chemistry can give rise to biology is one of the greatest challenges of contemporary science. Achieving life-like properties in chemical systems is therefore a popular topic of research. Synthetic chemical systems are usually determini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d5a73f59b10a83b1279bf8de7276b1
https://pubmed.ncbi.nlm.nih.gov/35357150

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Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

Autor: Jim Ottelé, Peter C. Kroon, Wouter H. Roos, Guillermo Monreal Santiago, Omer Markovitch, Sijbren Otto, Marc C. A. Stuart, Pim W. J. M. Frederix, Sourav Maity, Siewert J. Marrink

Publikováno v: J. Am. Chem. Soc.
Journal of the American Chemical Society
Journal of the American Chemical Society, 142(32), 13709-13717. AMER CHEMICAL SOC

Self-assembly features prominently in fields ranging from materials science to biophysical chemistry. Assembly pathways, often passing through transient intermediates, can control the outcome of assembly processes. Yet, the mechanisms of self-assembl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febeb8a72691d15c2a46820e7225f964
https://doi.org/10.1021/jacs.0c02635

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Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids

Autor: Charalampos G. Pappas, Jim Ottelé, Gaël Schaeffer, Bin Liu, Priscilla F Pieters, Meniz Altay, Sijbren Otto, Ivana Marić, Christoph Jurissek, Marc C. A. Stuart

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 142(9), 4184-4192. AMER CHEMICAL SOC

The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of ''RNA-peptide coevolution'' suggests that the current close relationship b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e43f3a94d7e28f3a820317c0216631
https://doi.org/10.1021/jacs.9b10796

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Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries

Autor: Patrick Onck, Sijbren Otto, Jim Ottelé, Ivana Marić, Marcus L van der Klok, Bin Liu, Armin Kiani, Charalampos G. Pappas

Publikováno v: Journal of the American Chemical Society, 143(19). AMER CHEMICAL SOC
Journal of the American Chemical Society

The ability of molecules and systems to make copies of themselves and the ability of molecules to fold into stable, well-defined three-dimensional conformations are of considerable importance in the formation and persistence of life. The question of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdca2b7ed331a03fe95d3a182699f8b
https://research.rug.nl/en/publications/0768d42e-c461-466e-b52a-e2837a066083

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Understanding emergent functional properties in self replicating systems

Autor: Jim Ottelé

This dissertation is focused on two major investigations. The first one is about the mechanism with which a known self-replicator can create copies of itself. This study led to the first real-time visualization of a molecule capable of self-replicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcf8f382962c3975190ea56eafdd27e
https://doi.org/10.33612/diss.182238948

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Automated device for continuous stirring while sampling in liquid chromatography systems

Autor: Jim Ottelé, Obe Veldman, Sijbren Otto, Omer Markovitch

Publikováno v: Communications chemistry, 3(1):180. Nature Publishing Group
Commun. Chem.

Ultra-performance liquid chromatography is a common analysis tool, and stirring is common in many laboratory setups. Here we show a device which enables continuous stirring of samples whilst inside an ultra-performance liquid chromatography system. U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae5fb5b0a5d091ce4ccd0d3f77e694a
https://hdl.handle.net/11370/587840c9-8b85-473a-8764-c93c85b9ef73

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