Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jim O'Prey"'
Supplementary Figure 2 from Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e35bae8cdc4e8e182e225a9cb5e4efc
https://doi.org/10.1158/0008-5472.22383501
https://doi.org/10.1158/0008-5472.22383501
The analysis of DNA tumor viruses has provided landmark insights into the molecular pathogenesis of cancer. A paradigm for this field has been the study of the adenoviral E1a protein, which has led to the identification of proteins such as p300, p400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc59f017b9df5efbffe61e641aa68e5
https://doi.org/10.1158/0008-5472.c.6500562
https://doi.org/10.1158/0008-5472.c.6500562
Supplementary Figure 1 from Oncogene-Induced Sensitization to Chemotherapy-Induced Death Requires Induction as well as Deregulation of E2F1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7535312d33df54951fe0cdab69c039e9
https://doi.org/10.1158/0008-5472.22383504.v1
https://doi.org/10.1158/0008-5472.22383504.v1
Autor:
Alice D. Baudot, Victoria M.-Y. Wang, Josh D. Leach, Jim O’Prey, Jaclyn S. Long, Viola Paulus-Hock, Sergio Lilla, David M. Thomson, John Greenhorn, Farah Ghaffar, Colin Nixon, Miep H. Helfrich, Douglas Strathdee, Judith Pratt, Francesco Marchesi, Sara Zanivan, Kevin M. Ryan
Macroautophagy promotes cellular homeostasis by delivering cytoplasmic constituents to lysosomes for degradation [Mizushima, Nat. Cell Biol. 20, 521–527 (2018)]. However, while most studies have focused on the mechanisms of protein degradation duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c727d4289e292e1955a57f5864dcafd
https://strathprints.strath.ac.uk/81389/1/Baudot_etal_PNAS_2022_Glycan_degradation_promotes_macroautophagy.pdf
https://strathprints.strath.ac.uk/81389/1/Baudot_etal_PNAS_2022_Glycan_degradation_promotes_macroautophagy.pdf
Autor:
Catherine Cloix, Malviya G, Kirsteen J. Campbell, Laura Martínez-Escardó, Kinch K, Dominik Koessinger, Paul N, Gabriel Ichim, Florian J. Bock, Elmasry Y, Kevin M. Ryan, Jane E. Norman, Jim O'Prey, Katrina Stevenson, Anthony J. Chalmers, Anna L. Koessinger, William Stewart, Colin Nixon, Kevin G. Blyth, Stephen W.G. Tait, Mark R. Jackson
IDH wild-type glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. Tackling this, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7beb81f8995f7f595c7b4985a488d12
https://doi.org/10.1101/2021.06.13.448232
https://doi.org/10.1101/2021.06.13.448232
Autor:
Anna L. Koessinger, Catherine Cloix, Dominik Koessinger, Dieter Henrik Heiland, Florian J. Bock, Karen Strathdee, Kevin Kinch, Laura Martínez-Escardó, Nikki R. Paul, Colin Nixon, Gaurav Malviya, Mark R. Jackson, Kirsteen J. Campbell, Katrina Stevenson, Sandeep Davis, Yassmin Elmasry, Asma Ahmed, Jim O’Prey, Gabriel Ichim, Oliver Schnell, William Stewart, Karen Blyth, Kevin M. Ryan, Anthony J. Chalmers, Jim C. Norman, Stephen W. G. Tait
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, 2022, 29 (10), pp.2089-2104. ⟨10.1038/s41418-022-01001-3⟩
Cell Death and Differentiation, 29(10), 2089-2104. Nature Publishing Group
Cell Death and Differentiation, 2022, 29 (10), pp.2089-2104. ⟨10.1038/s41418-022-01001-3⟩
Cell Death and Differentiation, 29(10), 2089-2104. Nature Publishing Group
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recurrence. We investigated the therapeutic po
Autor:
Sabine Roth, Owen J. Sansom, Mathias T. Rosenfeldt, Jim O'Prey, Kevin M. Ryan, Colin R Lindsay, Colin Nixon
Publikováno v:
Rosenfeldt, M T, O’Prey, J, Lindsay, C R, Nixon, C, Roth, S, Sansom, O J & Ryan, K M 2021, ' Loss of autophagy affects melanoma development in a manner dependent on PTEN status ', Cell Death and Differentiation, vol. 28, no. 4, pp. 1437-1439 . https://doi.org/10.1038/s41418-021-00746-7
Cell Death and Differentiation
Cell Death and Differentiation
Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous tumors, including melanoma. We utilized a genetically engineered mouse model of melanoma driven by oncogenic BrafV600E and deficiency in the Pten tumor suppressor gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265069762e309d685fde341392f5c308
https://research.manchester.ac.uk/en/publications/403ab0a8-1282-41a9-8610-d2c565297d14
https://research.manchester.ac.uk/en/publications/403ab0a8-1282-41a9-8610-d2c565297d14
Publikováno v:
ONCOGENE, 34(40), 5152-5162. Nature Publishing Group
Oncogene
Oncogene
Tumour cells often acquire the ability to escape cell death, a key event leading to the development of cancer. In almost half of all human cancers, the capability to induce cell death is reduced by the mutation and inactivation of p53, a tumour suppr
Autor:
Jim O'Prey, Daniel R. Croft, Naihan Xu, Mathias T. Rosenfeldt, Kevin M. Ryan, Yaou Zhang, Margaret O'Prey, Emma Y. Liu, Laurence Y. Lao, David A. F. Gillespie, Jaclyn S. Long, Alice D. Baudot, Sanket Joshi, Florian Beaumatin, Michaela Mrschtik
Publikováno v:
Proceedings of the National Academy of Sciences. 112:773-778
(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an explanation for this effect is currently unclear. We report here that inhibition
Autor:
Mathias T. Rosenfeldt, Jim O'Prey, Jennifer P. Morton, Kevin M. Ryan, Colin Nixon, Owen J. Sansom, Lucia Flossbach
Publikováno v:
Cell Death and Differentiation
No abstract available.