Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jim Na"'
Autor:
Imagawa, Nadine Abi-Jaoudeh, Ben Sadeghi, Hanna Javan, Jim Na, Graham Beaton, Fabio Tucci, Satheesh Ravula, David K.
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3236
Drug-eluting embolic transarterial chemoembolization (DEE-TACE) improves the overall survival of hepatocellular carcinoma (HCC), but the agents used are not tailored to HCC. Our patented liposomal formulation enables the loading and elution of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::cbd6eaa4246b7c2db8d1a5cd559977f3
Autor:
Eduardo V. Mercado-Marin, Jim Na, Renee L. DesJarlais, Helena C. Steffens, Genesis M. Bacani, Mark Seierstad, De Michael Chung, Taraneh Mirzadegan, Mark S. Tichenor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Drug discovery building blocks available commercially or within an internal inventory cover a diverse range of chemical space and yet describe only a tiny fraction of all chemically feasible reagents. Vendors will eagerly provide to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e8eae69e6bffcbc5c1849a0bd619e3
https://europepmc.org/articles/PMC8591720/
https://europepmc.org/articles/PMC8591720/
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Seierstad, Mark, Tichenor, Mark S., DesJarlais, Renee L., Jim Na, Bacani, Genesis M., Chung, De Michael, Mercado-Marin, Eduardo V., Steffens, Helena C., Mirzadegan, Taraneh
Publikováno v:
ACS Medicinal Chemistry Letters; 11/11/2021, Vol. 12 Issue 11, p1853-1860, 8p
Autor:
Aaron C. Burns, Andrew N. Valiere, Pawel Stanczak, Curtis E. Moore, Brian P. Dyck, Jim Na, Lino J. Valdez, Arnold L. Rheingold, Michael I. Weinhouse, Brett C. Bookser
Publikováno v:
The Journal of organic chemistry. 83(12)
Alkylation of 4-methoxy-1H-pyrazolo[3,4-d]pyrimidine (1b) with iodomethane in THF using NaHMDS as base selectively provided N2-methyl product 4-methoxy-2-methyl-2H-pyrazolo[3,4-d]pyrimidine (3b) in an 8/1 ratio over N1-methyl product (2b). Interestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779dd808a1e16e65759608717352640e
https://pubmed.ncbi.nlm.nih.gov/29790748
https://pubmed.ncbi.nlm.nih.gov/29790748
Autor:
Jim Nasr
Publikováno v:
Blockchain in Healthcare Today, Vol 6, Iss 1 (2023)
This session delves into a real use case that led to the development of an existing production quality consumer app currently available on both Apple App Store and Google Play. The discussion focuses on practical considerations, implementation decisi
Externí odkaz:
https://doaj.org/article/fae9817323f74b20a6384e18509c9154
Autor:
Franklin P. DeHaan, Bimal R. Patel, Jim Na, Steven K. Ma, Paul Y. Ahn, Carl R. Kemnitz, Richard M. Ruiz, Randy M. Villahermosa
Publikováno v:
International Journal of Chemical Kinetics. 30:367-372
Vacuum line kinetic studies of the reaction of p-toluenesulfonyl chloride and benzene or toluene, using aluminum chloride as the catalyst and dichloromethane as the solvent were determined at 25°C by means of gas chromatography. The reaction is firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5326fcc8aa6f35cd450e1c3f5fcdf0ff
https://doi.org/10.1002/(sici)1097-4601(1998)30:5<367::aid-kin7>3.0.co
https://doi.org/10.1002/(sici)1097-4601(1998)30:5<367::aid-kin7>3.0.co
Publikováno v:
Journal of the American Chemical Society. 118:6462-6471
In previous research, Hilvert and co-workers developed an antibody which catalyzes the decomposition of a nitrobenzisoxazole with a rate >108 times faster than the acetate-catalyzed reaction in water. Quantum mechanical calculations were carried out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6af4dd142c0fd524487222f497eee59b
https://doi.org/10.1021/ja953550j
https://doi.org/10.1021/ja953550j
Autor:
Michele Ramirez-Weinhouse, Jaroslav Kostrowicki, Zhengwei Peng, Atsuo Kuki, Xianjun Kong, Jim Na, Joe Zhongxiang Zhou, Sarathy Mattaparti, Javier Gonzalez, Bo Yang, Qiyue Hu, Thomas Thacher, Sutton Scott Channing
Publikováno v:
ACS combinatorial science. 14(11)
An unprecedented amount of parallel synthesis information was accumulated within Pfizer over the past 12 years. This information was captured by an informatics tool known as PGVL (Pfizer Global Virtual Library). PGVL was used for many aspects of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b7c241177a18a555c886f33864c30
https://pubmed.ncbi.nlm.nih.gov/23020747
https://pubmed.ncbi.nlm.nih.gov/23020747