Zobrazeno 1 - 10
of 784
pro vyhledávání: '"Jim Michaels"'
Autor:
Andrew Johnson, Chetan T. Goudar, Alois Knoll, Jürgen Lehmann, Rüdiger Heidemann, Jim Michaels, Klaus Joeris, Cary Matanguihan, Thomas Scheper, Chun Zhang, Jan-Gerd Frerichs, Konstantin Konstantinov
Publikováno v:
IFAC Proceedings Volumes. 37:387-391
We have developed a framework that is capable of providing complete automation of mammalian cell perfusion processes. This framework includes an expert system that provides low-level control of the process based on data obtained from online and offli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29918ebe2fb2075d0359a90c577a6c0
https://doi.org/10.1016/s1474-6670(17)32612-5
https://doi.org/10.1016/s1474-6670(17)32612-5
Autor:
Jim Michaels, Maria Ng, Richard Biener, Renato Meneses, Konstantin Konstantinov, Chetan T. Goudar, Chun Zhang, John Thrift
Publikováno v:
IFAC Proceedings Volumes. 34:137-142
The impact of changes in dilution rate and medium compositIon on the metabolism of CHO cells was studied in high cell density perfusion reactors. Medium composition and dilution rates were varied during the course of the experiment and nutrient and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a41b01c7d92958e67f6dcc6cf07d677
https://doi.org/10.1016/s1474-6670(17)34209-x
https://doi.org/10.1016/s1474-6670(17)34209-x
Autor:
J. Rule, Sandra Chuppa, Konstantin Konstantinov, S. Park, H. Qi, Rüdiger Heidemann, Chun Zhang, Jim Michaels, Carl Rozales, Manas K. Ray, David Naveh
Publikováno v:
Animal Cell Technology: Products from Cells, Cells as Products ISBN: 9780792360759
This paper describes the test of several new vegetarian hydrolysates (peptones of soy, rice, wheat gluten etc.) as protein-free medium supplements for the production of a recombinant therapeutic protein. Multiple peptone-supplemented, continuous perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d864194d9dc1591d13b61b327c71af
https://doi.org/10.1007/0-306-46875-1_45
https://doi.org/10.1007/0-306-46875-1_45
Autor:
Lia Tescione, Diana Cheung, Javier Femenia, Isabelle Nadeau, Jim Michaels, Stephen F. Gorfien, Delia Fernandez, Bryan Monroe
Publikováno v:
Animal Cell Technology: Basic & Applied Aspects ISBN: 9781402096457
The complexity and expense associated with large-scale perfusion culture systems make them impractical for medium optimization studies involving DOE approaches. We have employed scale-down processes involving shake flask cultures seeded at high den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ec22b33a27afa3a5be29beada7ff35
https://doi.org/10.1007/978-1-4020-9646-4_10
https://doi.org/10.1007/978-1-4020-9646-4_10
Autor:
Konstantin, Konstantinov, Chetan, Goudar, Maria, Ng, Renato, Meneses, John, Thrift, Sandy, Chuppa, Cary, Matanguihan, Jim, Michaels, David, Naveh
Publikováno v:
Advances in biochemical engineering/biotechnology. 101
High product titer is considered a strategic advantage of fed-batch over perfusion cultivation mode. The titer difference has been experimentally demonstrated and reported in the literature. However, the related theoretical aspects and strategies for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fc1a0cab75e6468a42160036a976379
https://pubmed.ncbi.nlm.nih.gov/16989258
https://pubmed.ncbi.nlm.nih.gov/16989258
Autor:
Jim Michaels, Chetan T. Goudar, Sandy Chuppa, Cary Matanguihan, David Naveh, John Thrift, Konstantin Konstantinov, Maria Ng, Renato Meneses
Publikováno v:
Cell Culture Engineering ISBN: 9783540340065
High product titer is considered a strategic advantage of fed-batch over perfusion cultivation mode. The titer difference has been experimentally demonstrated and reported in the literature. However, the related theoretical aspects and strategies for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04a59595c7b50e7d1157b10ba15dbe0
https://doi.org/10.1007/10_016
https://doi.org/10.1007/10_016
Autor:
Joshua A. Gregory, Jim Michaels, Nancy D. Dalton, Jeffrey B. Graham, Joseph J. Cech, N. Chin Lai
Publikováno v:
Comparative biochemistry and physiology. Part A, Molecularintegrative physiology. 138(2)
Sturgeons are primitive bony fishes and their hearts have structural features found in other primitive fishes. Sturgeons have a pericardioperitoneal canal (PPC), a one-way conduit into the peritoneum. A PPC also occurs in elasmobranchs (sharks and ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bebc81a05e2a182fb647c815d7ff89d
https://pubmed.ncbi.nlm.nih.gov/15275655
https://pubmed.ncbi.nlm.nih.gov/15275655
Autor:
M. Zachariou, C. Olson, Konstantin Konstantinov, John Thrift, R. Matanguihan, E. Sajan, Jim Michaels
Publikováno v:
Animal Cell Technology: From Target to Market ISBN: 9789401038973
High dissolved CO2 concentration (DCO2) is a major problem causing growth inhibition, metabolic changes, and poor productivity in mammalian cell culture. DCO2 often accumulates up to 200∓250 mmHg in perfusion bioreactors, while the optimal physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bbf7084408b05cbc509490e2e487343
https://doi.org/10.1007/978-94-010-0369-8_95
https://doi.org/10.1007/978-94-010-0369-8_95