Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jim Malliaros"'
Autor:
Tonia Woodberry, Joy Gardner, John Cooper Cox, Thuy T. Le, Debbie Drane, Linda Joy Rothel, Andreas Suhrbier, Jim Malliaros, Martin J. Pearse
Publikováno v:
Vaccine. 19:4669-4675
CD8 alphabeta cytotoxic T lymphocyte (CTL) polyepitope or polytope vaccines have traditionally been delivered using recombinant vector or DNA based delivery modalities. Here we show the delivery of polytope vaccines in the form of either synthetic po
Publikováno v:
Molecular Immunology. 33:57-61
The activity of the transcription factor NF-kappaB is tightly regulated by the inhibitory molecule IkappaBalpha. Upon stimulation, IkappaBalpha is rapidly degraded and NF-kappaB translocates to the nucleus to induce gene expression. The IkappaBalpha
Publikováno v:
Kidney International. 44:557-564
Glomerular fibrinolytic activity in anti-GBM glomerulonephritis in rabbits. Fibrin is an important mediator of injury in severe proliferative forms of glomerulonephritis (GN). Normal glomeruli express fibrinolytic activity, which may protect against
Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses
Autor:
Martin J. Pearse, Frances H. Arnold, Roderick I Macfarlan, Jim Malliaros, Debbie Drane, Charles Quinn, Trina J. Stewart
Publikováno v:
Vaccine. 22(29-30)
The association of antigen with ISCOMATRIX trade mark adjuvant has been shown to be important for the optimal induction of cytotoxic T lymphocyte (CTL) responses. Here, we describe a simple broadly applicable method for associating recombinant protei
Autor:
Karen Malcolm, Trina J. Stewart, Germain J. P. Fernando, Ian H. Frazer, Debbie Drane, Stirling John Edwards, Heidi Elmer, Jim Malliaros, John Cooper Cox
Publikováno v:
Vaccine. 22(27-28)
Human Papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are associated with cervical cancer development and progression and can therefore be used as target antigens for cancer immunotherapy. In this study we evaluated the immunogenicity in mice,