Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism†

Autor: Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Publikováno v: Biology of reproduction. 107(2)

Paternal obesity predisposes offspring to metabolic dysfunction, but the underlying mechanisms remain unclear. We investigated whether this metabolic dysfunction is associated with changes in placental vascular development and is fueled by endoplasmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dd786228fe4844482e7f3479b8983e
https://pubmed.ncbi.nlm.nih.gov/35377412

Early life exposure to undernutrition induces ER stress, apoptosis, and reduced vascularization in ovaries of adult rat offspring

Autor: Kaitlyn A, Chan, Angelica B, Bernal, Mark H, Vickers, Wajiha, Gohir, Jim J, Petrik, Deborah M, Sloboda

Publikováno v: Biology of reproduction. 92(4)

Maternal nutritional restriction has been shown to induce impairments in a number of organ systems including the ovary. We have previously shown that maternal undernutrition induces fetal growth restriction and low birth weight, and results in an off

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4baa3495a7212796c44d9d96a591ac93
https://pubmed.ncbi.nlm.nih.gov/25810471

Challenges in experimental modeling of ovarian cancerogenesis

Autor: Jim J, Petrik

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1049

Ovarian cancer is a complex disease, with unclear origins, complicated, multistep tumorigenesis, and variable outcomes. As such, generating experimental models to study the disease and treatment efficacies has proven to be extremely challenging. A nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef75fca2ef8ec80c78d9ef3b12898897
https://pubmed.ncbi.nlm.nih.gov/23913231

Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental vasculature.

Autor: Emily K Hayes, Anna Lechowicz, Jim J Petrik, Yaryna Storozhuk, Sabrina Paez-Parent, Qin Dai, Imtiaz A Samjoo, Margaret Mansell, Andree Gruslin, Alison C Holloway, Sandeep Raha

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33370 (2012)

Maternal obesity results in a number of obstetrical and fetal complications with both immediate and long-term consequences. The increased prevalence of obesity has resulted in increasing numbers of women of reproductive age in this high-risk group. S

Externí odkaz: https://doaj.org/article/7f8b3d040d4b4159b62972960b282290

Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype.

Autor: Ogilvie LM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Delfinis LJ; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Coyle-Asbil B; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Vudatha V; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Alshamali R; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Garlisi B; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Pereira M; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Matuszewska K; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Garibotti MC; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Gandhi S; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Brunt KR; Department of Pharmacology, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada; IMPART Investigator Team, Saint John, New Brunswick, Canada., Wood GA; Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada., Trevino JG; Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia., Perry CGR; School of Kinesiology & Health Science and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada., Petrik J; Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada., Simpson JA; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada; IMPART Investigator Team, Saint John, New Brunswick, Canada. Electronic address: jeremys@uoguelph.ca.

Publikováno v: The American journal of pathology [Am J Pathol] 2024 Oct; Vol. 194 (10), pp. 1823-1843. Date of Electronic Publication: 2024 Jul 18.