Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jim J-C Lin"'
Autor:
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhan-Peng Huang, Jianming Liu, Yi Wang, Hee Young Seok, Xiaoyun Hu, Qing Ma, Kathryn Li, Jan Kyselovic, Qingchuan Wang, Jenny L.-C. Lin, Jim J.-C. Lin, Douglas B. Cowan, Francisco Naya, Yuguo Chen, William T. Pu, Da-Zhi Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pat
Externí odkaz:
https://doaj.org/article/8da0d02d7d2444b1832b1613e9583e1a
Publikováno v:
Am J Physiol Cell Physiol
Calponin 2 is an actin cytoskeleton-associated protein and plays a role in regulating cell motility-related functions such as phagocytosis, migration, and division. We previously reported that overexpression of calponin 2 inhibits the rate of cell pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11036bf5a976db26a7b94e15d1474810
https://doi.org/10.1152/ajpcell.00569.2020
https://doi.org/10.1152/ajpcell.00569.2020
Autor:
Douglas B. Cowan, Qing Ma, Kathryn Li, Francisco J. Naya, Haipeng Guo, Yi Wang, Qingchuan Wang, Xiaoyun Hu, Zhiqiang Lin, Jianming Liu, Jan Kyselovic, Hee Young Seok, Da-Zhi Wang, Jenny Li-Chun Lin, Yao Wei Lu, William T. Pu, Zhan-Peng Huang, Yuguo Chen, Jim J.-C. Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20cffb5ab62e82d32c2b24f334d96
http://link.springer.com/article/10.1038/s41467-020-18379-8
http://link.springer.com/article/10.1038/s41467-020-18379-8
Autor:
Tiago Fernandes, Francisco J. Naya, Zhiqiang Lin, Yuxuan Guo, Xiaoyun Hu, Jenny Li-Chun Lin, Haipeng Guo, Jim J.-C. Lin, Da-Zhi Wang, Jianming Liu, William T. Pu, Zhan-Peng Huang, Yi Wang, Yao Wei Lu
Publikováno v:
Circulation Research. 125
Cardiovascular diseases continue to be a leading cause of death and disability. Despite this alarming fact, there is lack of effectual treatment and the molecular mechanisms underlying these devastating diseases remain elusive. Intercalated disk (ICD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f836c25edcfd97aa00d3f16b5b99f9
https://doi.org/10.1161/res.125.suppl_1.919
https://doi.org/10.1161/res.125.suppl_1.919
Autor:
Qiuping Wu, Jian Guo, Lei Huang, Qinchuan Wang, Liyong Zhang, Jianding Cheng, Shih-Hurng Loh, Kuo Ho Wu, Shuangbo Tang, Jim J.-C. Lin, Pei Hsiu Jiang, Lin Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sudden unexplained nocturnal death syndrome ( SUNDS ) remains an autopsy negative entity with unclear etiology. Arrhythmia has been implicated in SUNDS . Mutations/deficiencies in intercalated disc components have been shown to cause arrhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cd95732423df8e214e58fa20816319
https://doi.org/10.1161/jaha.117.006320
https://doi.org/10.1161/jaha.117.006320
Autor:
Jim J.-C. Lin, David P. Corey, Zheng-Yi Chen, K. Domenica Karavitaki, Duan Sun Zhang, Jun Shen, Artur A. Indzhykulian, Qinchuan Wang, Deborah I. Scheffer, Yichao Joy Xu
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1811-1818 (2015)
SummaryHair cells of the inner ear are mechanoreceptors for hearing and balance, and proteins highly enriched in hair cells may have specific roles in the development and maintenance of the mechanotransduction apparatus. We identified XIRP2/mXinβ as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662ad83c66fbc0e9c733e984db1ae652
Autor:
Xiaomin Xing, Atsushi Ueda, Jim J.-C. Lin, Kyle Belozerov, Spencer T. Mukai, Xuxuan Wan, Hongyu Ruan, David S. Green, Wayne A. Johnson, Wei-Dong Yao, Arthur J. Hilliker, Benjamin Strub, Kaan Certel, Chun-Fang Wu
Publikováno v:
Journal of neurogenetics. 31(4)
Our earlier genetic screen uncovered a paraquat-sensitive leg-shaking mutant quiver1 (qvr1), whose gene product interacts with the Shaker (Sh) K+ channel (Humphreys et al, 1996; Wang et al., 2000). We also mapped the qvr locus to EY04063 and noticed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6728d27406849a0e5956df26f823ad59
https://pubmed.ncbi.nlm.nih.gov/29117754
https://pubmed.ncbi.nlm.nih.gov/29117754
Publikováno v:
Molecular & Cellular Proteomics. 12:3094-3107
Pressure-overload stress to the heart causes pathological cardiac hypertrophy, which increases the risk of cardiac morbidity and mortality. However, the detailed signaling pathways induced by pressure overload remain unclear. Here we used phosphoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beb097d3361f5a884a881c7b05e5814
https://doi.org/10.1074/mcp.m113.027649
https://doi.org/10.1074/mcp.m113.027649
Publikováno v:
Archives of Biochemistry and Biophysics. 535:91-100
The Xin repeat-containing proteins, Xinα (Xirp1) and Xinβ (Xirp2), localize to the intercalated discs (ICDs) of mammalian hearts. Mouse Xinα (mXinα) directly interacts with β-catenin and actin filaments, potentially coupling the N-cadherin/β-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2608ec07e512049ab544475b38713ce
https://doi.org/10.1016/j.abb.2012.12.018
https://doi.org/10.1016/j.abb.2012.12.018
Autor:
Elisabeth A. Gustafson-Wagner, Chiao Pei Cheng, Kuo Ho Wu, Fu Chi Chan, Chih Hsiung Hsu, Cheng I. Lin, Yao Chang Chen, Jenny Li-Chun Lin, Jim J.-C. Lin, Qinchuan Wang
Publikováno v:
Frontiers in Bioscience. :1425-1442
Mouse Xin-alpha (mXin-alpha) encodes a Xin repeat-containing, actin-binding protein localized to the intercalated disc (ICD). Ablation of mXin-alpha progressively leads to disrupted ICD structure, cardiac hypertrophy and cardiomyopathy with conductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7e74e39a4f01d6d792395958f3f845
https://doi.org/10.2741/e344
https://doi.org/10.2741/e344