Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Jim Iley"'
Autor:
Mark E. Light, Abdul K. Choudhury, Raymond C. F. Jones, Terence A. Pillainayagam, Jim Iley, Georgia Loizou
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 308-312 (2012)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9030705078aeebcb94610afb8b871a7
https://doaj.org/article/44dce0977cf04d76b61b270ae0f8e9af
https://doaj.org/article/44dce0977cf04d76b61b270ae0f8e9af
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:886-892
O -Alkyl and O -aryl carbamate derivatives of the antimalarial drug primaquine were synthesised as potential prodrugs that prevent oxidative deamination to the inactive metabolite carboxyprimaquine. Both O -alkyl and O -aryl carbamates undergo hydrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f6a2c6a4402e1a4600bb465bf24f24
https://doi.org/10.1016/j.bmc.2011.11.059
https://doi.org/10.1016/j.bmc.2011.11.059
Publikováno v:
Journal of Physical Organic Chemistry. 24:1081-1087
The reactivity of 6-quinolinyl and 8-quinolinyl N,N-dimethylcarbamates was examined in several aqueous basic media. A quadratic dependence was observed for the constant rates upon hydroxide concentration for both compounds, which is a typical behavio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d053d18e415a0f4922dbfdaece8920c7
https://doi.org/10.1002/poc.1835
https://doi.org/10.1002/poc.1835
Publikováno v:
ARKIVOC, Vol 2011, Iss 4, Pp 82-103 (2011)
S-Alkylation of an N-protected cysteine ester with a range of ω-iodoalkyl heterocycles affords 11 novel non-proteinogenic heterocyclic amino acids having a sulfur atom in the backboneheterocycle linker.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec70659d2f7ad769455dbf7622a756e
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0012.408
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0012.408
Autor:
Carla Eleutério, Maria Manuela Gaspar, Jalmira Mulchande, Sandra Simões, M.E.M. Cruz, Rudi Oliveira, Rui Moreira, Jim Iley
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 26:169-175
The 4-oxo-β-lactams (azetidine-2,4-diones) are potent acylating agents of the human leukocyte elastase (HLE), a neutrophil serine protease that plays a key role in several inflammatory diseases. A novel 4-oxo-β-lactam containing a N-(4-(phenylsulph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd870d6f5dc4d4051bb11576adc7b0e
https://doi.org/10.3109/14756366.2010.486794
https://doi.org/10.3109/14756366.2010.486794
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0194724 (2018)
PLoS ONE, Vol 13, Iss 4, p e0194724 (2018)
It is generally recognized that insect odorant binding proteins (OBPs) mediate the solubilisation and transport of hydrophobic odorant molecules and contribute to the sensitivity of the insect olfactory system. However, the exact mechanism by which O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b0b1697fd64e29b25f54323174367f
https://doi.org/10.1371/journal.pone.0194724
https://doi.org/10.1371/journal.pone.0194724
Autor:
Abdul K. Choudhury, Raymond C. F. Jones, Jim Iley, Vickie McKee, Christopher Lumley, Georgia Loizou
Publikováno v:
Synlett. 2010:654-658
A core isoxazolo[4,3-c]pyridin-4-one scaffold is prepared and elaborated at C-3(Me) and C-7 as a masked building block for 3-acylpyridin-2-ones related to the acylpyridone natural products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::562306f5b394b44e61d0b4e4a0c775b6
https://doi.org/10.1055/s-0029-1219341
https://doi.org/10.1055/s-0029-1219341
Publikováno v:
ARKIVOC, Vol 2007, Iss 5, Pp 152-166 (2006)
Dipolar cycloadditions of azomethine imines, formed in situ from aldehydes and N1-alkyl-N2-acylhydrazines, with electron-deficient dipolarophiles produce pyrazolidines: mono-substituted dipolarophiles afford principally 4-substituted pyrazolidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ad47309cbfffd905dce6af6daea9e5
https://doi.org/10.3998/ark.5550190.0008.513
https://doi.org/10.3998/ark.5550190.0008.513
Publikováno v:
Journal of Chemical Research. 2006:664-667
Substituted secondary N-thiazolylcarbamate esters and some tertiary N-methyl, N-thiazolyl carbamate esters have been synthesised and the mechanism of the OH- catalysed hydrolyses investigated. These proved to be E1cB and BAc2 respectively, and this b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5286d582180e9c5dbdac58282355358f
https://doi.org/10.3184/030823406779173578
https://doi.org/10.3184/030823406779173578
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Carbamate and ester derivatives of the 1,1-dioxobenzo[b]thiophen-2-ylmethyloxycarbonyl (Bsmoc) scaffold react readily with thiols via a Michael addition at rates not significantly affected by the nature of the carboxylic or carbamic acid leaving grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0083d11d4e9665f198718d02c988ade9
https://doi.org/10.1016/j.bmcl.2006.02.007
https://doi.org/10.1016/j.bmcl.2006.02.007