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pro vyhledávání: '"Jim Henry, Hughes"'
Autor:
Alia Fahmy, Michael J. Sorich, Jim Henry Hughes, Andrew Rowland, Ganessan Kichenadasse, Ashley H. Hopkins
Vemurafenib, a B rapidly accelerated fibrosarcoma inhibitor, is commonly used in combination of cobimetinib for the treatment of melanoma. In the current study, we evaluated the relationship between vemurafenib exposure, as measured by the estimated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b5ecfb3f7e546430987bec3fefdbb2
https://hdl.handle.net/11541.2/29353
https://hdl.handle.net/11541.2/29353
Autor:
Ganessan, Kichenadasse, Jim Henry, Hughes, John O, Miners, Arduino A, Mangoni, Andrew, Rowland, Ashley M, Hopkins, Michael J, Sorich
Publikováno v:
Cancer chemotherapy and pharmacology. 85(3)
Purpose To validate a plasma vemurafenib steady-state trough concentration (CA pooled analysis of individual patient data from two advanced melanoma trials involving vemurafenib ± cobimetinib therapy was performed. Day 23 was chosen as the landmark